Abstract
V-79 Chinese hamster lung fibroblasts and C3H-10T1/2 mouse embryo cells were used to study the toxicity and transformation effects of the 5α, 6α-, and 5β, 6β-epoxy derivatives of cholesterol. Both epoxides were found to be carcinogenic, and the transformation frequency increased with epoxide concentration and exposure time. The 5β, 6β-epoxide caused a higher level of transformation than the α-isomer, and this is consistent with its greater toxicity.