Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil

Journal article

Peer reviewed

Gina M Capiaux, Tulin BUDAK-ALPDOGAN, Naoko Takebe, Philipp MAYER-KUCKUK, Debabrata Banerjee, Frank Maley and Joseph R Bertino

Human gene therapy, Vol.14(5), pp.435-446

2003

PMID: 12691609

Abstract

Biological and medical sciences

Classical genetics, quantitative genetics, hybrids

Fundamental and applied biological sciences. Psychology

Genetics of eukaryotes. Biological and molecular evolution

Human

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Title: Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil
Creators: Gina M Capiaux - Graduate School of Medical Sciences, Cornell University, New York, NY 10021, United States
Tulin BUDAK-ALPDOGAN - Program of Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States
Naoko Takebe - Program of Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States
Philipp MAYER-KUCKUK - Program of Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States
Debabrata Banerjee - Program of Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States
Frank Maley - New York State Department of Health, Wadsworth Center, Albany, NY 12201, United States
Joseph R Bertino - Graduate School of Medical Sciences, Cornell University, New York, NY 10021, United States
Publication Details: Human gene therapy, Vol.14(5), pp.435-446
Date published: 2003
Publisher: Liebert
Academic Unit: Pharmacology (RWJMS); Bertino Office
Language: English
Resource Type: Journal article
Identifiers: 991031665527304646