Abstract
The amino acid glycine is the major inhibitory neurotransmitter of spinal cord and brain stem. The termination of the action of glycine is mediated by rapid reuptake into the presynaptic terminal or surrounding glial cells. Two glycine transporters, GLYT1 and GLYT2, are known. They display distinct distributions and are members of the sodium/chloride-dependent transporter family, which share 40-50% amino acid similarity and are characterized by 12 putative transmembrane regions. GLYT2 differs from GLYT1 in molecular structure, tissue specificity, and pharmacologic properties …