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Maternally Acting Alleles in Autism and Other Neurodevelopmental Disorders: The Role of HLA-DR4 Within the Major Histocompatibility Complex
Book chapter

Maternally Acting Alleles in Autism and Other Neurodevelopmental Disorders: The Role of HLA-DR4 Within the Major Histocompatibility Complex

William G Johnson, Steven Buyske, Edward S Stenroos and George H Lambert
Maternal Influences on Fetal Neurodevelopment, pp.137-160
Springer New York
09/02/2010
DOI: https://doi.org/10.1007/978-1-60327-921-5_9

Abstract

Autism Developmental genes Maternal Maternal effects Maternally acting gene alleles Pregnancy Teratogenesis
Autism is a common and devastating neurodevelopmental disorder that begins in early childhood and whose causes are believed to be the interactions of multiple genes with environmental factors. These genes are usually thought of as acting in the individual with autism. In this chapter, an additional category of genes is considered: maternal genes that act in the mothers (most likely) during pregnancy to contribute to the autism phenotype of their affected offspring.

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