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Molecular Alterations Associated with Colitis‐Associated Colon Carcinogenesis
Book chapter

Molecular Alterations Associated with Colitis‐Associated Colon Carcinogenesis

Steven Itzkowitz and Lea Ann Chen
Inflammatory Bowel Disease, pp.508-517
Wiley‐Blackwell
04/26/2010
DOI: https://doi.org/10.1002/9781444318418.ch34

Abstract

anti‐inflammatory agents ‐ 5‐aminosalicylic acid, steroids, purine immunomodulators molecular alterations ‐ colitis‐associated colon carcinogenesis oxidative stress ‐ associated with inflammation p53 protein ‐ preventing clonal expansion of mutant cells TLR4 ‐ cell surface receptor recognizing bacterial products tumor suppressor genes ‐ cellular genes controlling cell proliferation, death and differentiation types of genomic instability ‐ chromosomal instability, microsatellite instability

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