Simulation of growth cone pathfindiing

S.M Maskery; H.M Buettner

doi:10.1109/CNE.2003.1196802

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Conference proceeding

Simulation of growth cone pathfindiing

S.M Maskery and H.M Buettner

First International IEEE EMBS Conference on Neural Engineering, 2003. Conference Proceedings, Vol.2003-, pp.237-240

2003

DOI: https://doi.org/10.1109/CNE.2003.1196802

Abstract

Biological system modeling

Biomedical engineering

Chemical engineering

In vitro

In vivo

Injuries

Mathematical model

Nerve fibers

Nervous system

Neurons

We have developed a quantitative model for growth cone guidance and migration in complex, biologically relevant environments. Our model has three main components: random growth cone migration, sampling of the growth cone's environment, and biased growth cone migration upon contact with a guidance cue. In this paper we present the development of our model and preliminary results. We plan to apply our model to simulate growth cone migration through a permissive pathway, an environment previously tested in vitro on micropatterned surfaces and observed in vivo during development. By manipulating the strength and arrangement of simulated guidance cues we will be able to infer how manipulation of the growth cone's environment affects the growth cone's ability to pathfind.

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Details

Title: Simulation of growth cone pathfindiing
Creators: S.M Maskery - Dept. of Chem. & Biochem. Eng., Rutgers Univ., Piscataway, NJ, USA
H.M Buettner - Dept. of Chem. & Biochem. Eng., Rutgers Univ., Piscataway, NJ, USA
Publication Details: First International IEEE EMBS Conference on Neural Engineering, 2003. Conference Proceedings, Vol.2003-, pp.237-240
Date published: 2003
Publisher: IEEE
Academic Unit: Biomedical Engineering (SOE)
Language: English
Resource Type: Conference proceeding
Identifiers: 991031666137704646