Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study

Suzanne C Dixon; Christina M Nagle; Aaron P Thrift; Paul Dp Pharoah; Celeste Leigh Pearce; Wei Zheng; Jodie N Painter; Georgia Chenevix-Trench; Peter A Fasching; Matthias W Beckmann; Diether Lambrechts; Ignace Vergote; Sandrina Lambrechts; Els Van Nieuwenhuysen; Mary Anne Rossing; Jennifer A Doherty; Kristine G Wicklund; Jenny Chang-Claude; Anja Rudolph; Kirsten B Moysich; Kunle Odunsi; Marc T Goodman; Lynne R Wilkens; Pamela J Thompson; Yurii B Shvetsov; Thilo Dörk; Tjoung-Won Park-Simon; Peter Hillemanns; Natalia Bogdanova; Ralf Butzow; Heli Nevanlinna; Liisa M Pelttari; Arto Leminen; Francesmary Modugno; Roberta B Ness; Robert P Edwards; Joseph L Kelley; Florian Heitz; Beth Y Karlan; Susanne K Kjær; Estrid Høgdall; Allan Jensen; Ellen L Goode; Brooke L Fridley; Julie M Cunningham; Stacey J Winham; Graham G Giles; Fiona Bruinsma; Roger L Milne; Melissa C Southey; Michelle A T Hildebrandt; Xifeng Wu; Karen H Lu; Dong Liang; Douglas A Levine; Maria Bisogna; Joellen M Schildkraut; Andrew Berchuck; Daniel W Cramer; Kathryn L Terry; Elisa V Bandera; Sara H Olson; Helga B Salvesen; Liv Cecilie Thomsen; Reidun K Kopperud; Line Bjorge; Lambertus A Kiemeney; Leon F A G Massuger; Tanja Pejovic; Linda S Cook; Nhu D Le; Kenneth D Swenerton; Angela Brooks-Wilson; Linda E Kelemen; Jan Lubiński; Tomasz Huzarski; Jacek Gronwald; Janusz Menkiszak; Nicolas Wentzensen; Louise Brinton; Hannah Yang; Jolanta Lissowska; Claus K Høgdall; Lene Lundvall; Honglin Song; Jonathan P Tyrer; Ian Campbell; Diana Eccles; James Paul; Rosalind Glasspool; Nadeem Siddiqui; Alice S Whittemore; Weiva Sieh; Valerie McGuire; Joseph H Rothstein; Steven A Narod; Catherine Phelan; Harvey A Risch; John R McLaughlin; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A Gayther; Susan J Ramus; Aleksandra Gentry-Maharaj; Anna H Wu; Malcolm C Pike; Chiu-Chen Tseng; Jolanta Kupryjanczyk; Agnieszka Dansonka-Mieszkowska; Agnieszka Budzilowska; Beata Spiewankiewicz; Penelope M Webb; AOCS Group & Australian Cancer Study (Ovarian Cancer)

doi:10.1093/ije/dyw158

Back

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study

Journal article

Open access

Peer reviewed

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study

Suzanne C Dixon, Christina M Nagle, Aaron P Thrift, Paul Dp Pharoah, Celeste Leigh Pearce, Wei Zheng, Jodie N Painter, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, …

International journal of epidemiology, Vol.45(3), pp.884-895

06/2016

DOI: https://doi.org/10.1093/ije/dyw158

PMCID: PMC5644573

PMID: 27401727

Abstract

Adolescent

Adult

Aged

Aged, 80 and over

Alleles

Body Mass Index

Female

Genome-Wide Association Study

Genotype

Humans

Logistic Models

Mendelian Randomization Analysis

Meta-Analysis as Topic

Middle Aged

Multivariate Analysis

Obesity - complications

Obesity - genetics

Ovarian Neoplasms - epidemiology

Ovarian Neoplasms - genetics

Polymorphism, Single Nucleotide

Risk Factors

Young Adult

Genetic Markers

Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents a causal effect, or holds for all histological subtypes. The lack of association observed for serous cancers may, for instance, be due to disease-associated weight loss. Mendelian randomization (MR) uses genetic markers as proxies for risk factors to overcome limitations of observational studies. We used MR to elucidate the relationship between BMI and ovarian cancer, hypothesizing that genetically predicted BMI would be associated with increased risk of non-high grade serous ovarian cancers (non-HGSC) but not HGSC. We pooled data from 39 studies (14 047 cases, 23 003 controls) in the Ovarian Cancer Association Consortium. We constructed a weighted genetic risk score (GRS, partial F-statistic = 172), summing alleles at 87 single nucleotide polymorphisms previously associated with BMI, weighting by their published strength of association with BMI. Applying two-stage predictor-substitution MR, we used logistic regression to estimate study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted BMI and risk, and pooled these using random-effects meta-analysis. Higher genetically predicted BMI was associated with increased risk of non-HGSC (pooled OR = 1.29, 95% CI 1.03-1.61 per 5 units BMI) but not HGSC (pooled OR = 1.06, 95% CI 0.88-1.27). Secondary analyses stratified by behaviour/subtype suggested that, consistent with observational data, the association was strongest for low-grade/borderline serous cancers (OR = 1.93, 95% CI 1.33-2.81). Our data suggest that higher BMI increases risk of non-HGSC, but not the more common and aggressive HGSC subtype, confirming the observational evidence.

Files and links (1)

url

https://doi.org/10.1093/ije/dyw158View

Version of Record (VoR) Open

Metrics

16 Record Views

56 Times Cited - Web of Science

See more details

Details

Title: Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study
Creators: Suzanne C Dixon - Gynaecological Cancers Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia The University of Queensland, School of Public Health, Brisbane, QLD, Australia Suzanne.Dixon@qimrberghofer.edu.au
Christina M Nagle - Gynaecological Cancers Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia The University of Queensland, School of Public Health, Brisbane, QLD, Australia
Aaron P Thrift - Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA
Paul Dp Pharoah - Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
Celeste Leigh Pearce - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Wei Zheng - Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Jodie N Painter - Molecular Cancer Epidemiology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
Georgia Chenevix-Trench - Cancer Genetics Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
Peter A Fasching - University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, CA, USA University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen, Germany
Matthias W Beckmann - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen, Germany
Diether Lambrechts - Vesalius Research Center, VIB, Leuven, Belgium Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium
Ignace Vergote - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Sandrina Lambrechts - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Els Van Nieuwenhuysen - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Department of Epidemiology, University of Washington, Seattle, WA, USA
Jennifer A Doherty - Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA
Kristine G Wicklund - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Jenny Chang-Claude - German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany
Anja Rudolph - German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
Kunle Odunsi - Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA
Marc T Goodman - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
Pamela J Thompson - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
Thilo Dörk - Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
Tjoung-Won Park-Simon - Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
Peter Hillemanns - Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
Natalia Bogdanova - Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
Ralf Butzow - Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Liisa M Pelttari - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Arto Leminen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Francesmary Modugno - Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
Roberta B Ness - The University of Texas School of Public Health, Houston, TX, USA
Robert P Edwards - Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Joseph L Kelley - Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Florian Heitz - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Susanne K Kjær - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Estrid Høgdall - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Allan Jensen - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Ellen L Goode - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA
Brooke L Fridley - University of Kansas Medical Center, Kansas City, KS, USA
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Stacey J Winham - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA
Graham G Giles - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia
Fiona Bruinsma - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia
Roger L Milne - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia
Melissa C Southey - Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia
Michelle A T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Karen H Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA
Douglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Maria Bisogna - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Joellen M Schildkraut - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
Daniel W Cramer - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA
Kathryn L Terry - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA
Elisa V Bandera - Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Helga B Salvesen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Liv Cecilie Thomsen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Reidun K Kopperud - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Line Bjorge - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Lambertus A Kiemeney - Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands
Leon F A G Massuger - Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Gynaecology, Nijmegen, The Netherlands
Tanja Pejovic - Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA
Linda S Cook - Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA
Nhu D Le - Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada
Kenneth D Swenerton - Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Angela Brooks-Wilson - Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada
Linda E Kelemen - Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA
Jan Lubiński - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Tomasz Huzarski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Jacek Gronwald - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Janusz Menkiszak - Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Louise Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Hannah Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Claus K Høgdall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Lene Lundvall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Honglin Song - Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Jonathan P Tyrer - Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Ian Campbell - Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia Department of Pathology, University of Melbourne, Parkville, VIC, Australia
Diana Eccles - Faculty of Medicine, University of Southampton, Southampton, UK
James Paul - The Beatson West of Scotland Cancer Centre, Glasgow, UK
Rosalind Glasspool - The Beatson West of Scotland Cancer Centre, Glasgow, UK
Nadeem Siddiqui - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK
Alice S Whittemore - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
Weiva Sieh - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
Valerie McGuire - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
Joseph H Rothstein - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
Steven A Narod - Women's College Research Institute, University of Toronto, Toronto, ON, Canada
Catherine Phelan - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA
John R McLaughlin - Public Health Ontario, Toronto, ON, Canada
Hoda Anton-Culver - Department of Epidemiology, University of California Irvine, Irvine, CA, USA Genetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA
Argyrios Ziogas - Department of Epidemiology, University of California Irvine, Irvine, CA, USA
Usha Menon - Women's Cancer, Institute for Women's Health, University College London, London, UK
Simon A Gayther - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Susan J Ramus - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Aleksandra Gentry-Maharaj - Women's Cancer, Institute for Women's Health, University College London, London, UK
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Malcolm C Pike - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Chiu-Chen Tseng - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Jolanta Kupryjanczyk - Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Agnieszka Dansonka-Mieszkowska - Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Agnieszka Budzilowska - Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Beata Spiewankiewicz - Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Penelope M Webb - Gynaecological Cancers Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia The University of Queensland, School of Public Health, Brisbane, QLD, Australia
AOCS Group & Australian Cancer Study (Ovarian Cancer)
Publication Details: International journal of epidemiology, Vol.45(3), pp.884-895
Date published: 06/2016
Grant note: R03 CA113148 / NCI NIH HHS N01 CN025403 / NCI NIH HHS UM1 CA182910 / NCI NIH HHS Department of Health R01 CA058860 / NCI NIH HHS K22 CA138563 / NCI NIH HHS R01 CA063678 / NCI NIH HHS R03 CA115195 / NCI NIH HHS K07 CA095666 / NCI NIH HHS R01 CA112523 / NCI NIH HHS R01 CA063682 / NCI NIH HHS C1287/A10710 / Cancer Research UK M01 RR000056 / NCRR NIH HHS MSH-87734 / CIHR 10124 / Cancer Research UK P50 CA159981 / NCI NIH HHS C5047/A15007 / Cancer Research UK P50 CA105009 / NCI NIH HHS UL1 TR000124 / NCATS NIH HHS C5047/A8384 / Cancer Research UK C5047/A10692 / Cancer Research UK C1287/A10118 / Cancer Research UK R01 CA095023 / NCI NIH HHS K07 CA143047 / NCI NIH HHS P30 CA016056 / NCI NIH HHS P30 CA008748 / NCI NIH HHS C12292/A11174 / Cancer Research UK MOP-86727 / CIHR C536/A6689 / Cancer Research UK C536/A13086 / Cancer Research UK C490/A16561 / Cancer Research UK P50 CA136393 / NCI NIH HHS R01 CA122443 / NCI NIH HHS C8197/A16565 / Cancer Research UK C1281/A12014 / Cancer Research UK P30 CA072720 / NCI NIH HHS C1312/A15589 / Cancer Research UK
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665373704646