Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

S.S An; T.R Bai; J.H.T Bates; J.L Black; R.H Brown; V Brusasco; P Chitano; L Deng; M Dowell; D.H Eidelman; B Fabry; N.J Fairbank; L.E Ford; J.J Fredberg; W.T Gerthoffer; S.H Gilbert; R Gosens; S.J Gunst; A.J Halayko; R.H Ingram; C.G Irvin; A.L James; L.J Janssen; G.G King; D.A Knight; A.M Lauzon; O.J Lakser; M.S Ludwig; K.R Lutchen; G.N Maksym; J.G Martin; T Mauad; B.E McParland; S.M Mijailovich; H.W Mitchell; R.W Mitchell; W Mitzner; T.M Murphy; P.D Paré; R Pellegrino; M.J Sanderson; R.R Schellenberg; C.Y Seow; P.S.P Silveira; P.G Smith; J Solway; N.L Stephens; P.J Sterk; A.G Stewart; D.D Tang; R.S Tepper; T Tran; L Wang

doi:10.1183/09031936.00112606

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Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

Journal article

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Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

S.S An, T.R Bai, J.H.T Bates, J.L Black, R.H Brown, V Brusasco, P Chitano, L Deng, M Dowell, D.H Eidelman, …

The European respiratory journal, Vol.29(5), pp.834-860

05/2007

DOI: https://doi.org/10.1183/09031936.00112606

PMCID: PMC2527453

PMID: 17470619

Abstract

muscle contraction

parenchyma

lung function

muscle adaptation

Airway mechanics

interdependence

Excessive airway obstruction is the cause of symptoms and abnormal lung function in asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is suspected that dysfunction of ASM contributes to the pathophysiology of asthma. However, the precise role of ASM in the series of events leading to asthmatic symptoms is not clear. It is not certain whether, in asthma, there is a change in the intrinsic properties of ASM, a change in the structure and mechanical properties of the noncontractile components of the airway wall, or a change in the interdependence of the airway wall with the surrounding lung parenchyma. All these potential changes could result from acute or chronic airway inflammation and associated tissue repair and remodelling. Anti-inflammatory therapy, however, does not “cure” asthma, and airway hyperresponsiveness can persist in asthmatics, even in the absence of airway inflammation. This is perhaps because the therapy does not directly address a fundamental abnormality of asthma, that of exaggerated airway narrowing due to excessive shortening of ASM. In the present study, a central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored.

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Title: Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
Creators: S.S An - Division of Physiology, Dept of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health
T.R Bai - James Hogg iCAPTURE Centre, University of British Columbia, Vancouver
J.H.T Bates - Vermont Lung Center, University of Vermont College of Medicine, Burlington, VT
J.L Black - Dept of Pharmacology, University of Sydney, Sydney
R.H Brown - Dept of Anesthesiology and Critical Care medicine, Johns Hopkins Medical Institutions, Baltimore, MD
V Brusasco - Dept of Internal Medicine, University of Genoa, Genoa
P Chitano - Dept of Paediatrics, Duke University Medical Center, Durham, NC
L Deng - Program in Molecular and Integrative Physiological Sciences, Dept of Environmental Health, Harvard School of Public Health
M Dowell - Section of Pulmonary and Critical Care Medicine
D.H Eidelman - Meakins-Christie Laboratories, Dept of Medicine, McGill University, Montreal
B Fabry - Center for Medical Physics and Technology, Erlangen, Germany
N.J Fairbank - School of Biomedical Engineering, Dalhousie University, Halifax
L.E Ford - Krannert Institute of Cardiology
J.J Fredberg - Program in Molecular and Integrative Physiological Sciences, Dept of Environmental Health, Harvard School of Public Health
W.T Gerthoffer - Dept of Pharmacology, University of Nevada School of Medicine, Reno, NV
S.H Gilbert - Krannert Institute of Cardiology
R Gosens - Dept of Physiology, University of Manitoba, Winnipeg
S.J Gunst - Dept of Physiology, Indiana University School of Medicine, Indianapolis, IN
A.J Halayko - Dept of Physiology, University of Manitoba, Winnipeg
R.H Ingram - Dept of Medicine, Emory University School of Medicine, Atlanta, GA
C.G Irvin - Vermont Lung Center, University of Vermont College of Medicine, Burlington, VT
A.L James - West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands
L.J Janssen - Dept of Medicine, McMaster University, Hamilton, Canada
G.G King - Woolcock Institute of Medical Research, Camperdown
D.A Knight - James Hogg iCAPTURE Centre, University of British Columbia, Vancouver
A.M Lauzon - Meakins-Christie Laboratories, Dept of Medicine, McGill University, Montreal
O.J Lakser - Section of Paediatric Pulmonary Medicine, University of Chicago, Chicago, IL
M.S Ludwig - Meakins-Christie Laboratories, Dept of Medicine, McGill University, Montreal
K.R Lutchen - Dept of Biomedical Engineering, Boston University, Boston
G.N Maksym - School of Biomedical Engineering, Dalhousie University, Halifax
J.G Martin - Meakins-Christie Laboratories, Dept of Medicine, McGill University, Montreal
T Mauad - Dept of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
B.E McParland - Dept of Pharmacology, University of Sydney, Sydney
S.M Mijailovich - Program in Molecular and Integrative Physiological Sciences, Dept of Environmental Health, Harvard School of Public Health
H.W Mitchell - Discipline of Physiology, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Perth
R.W Mitchell - Section of Pulmonary and Critical Care Medicine
W Mitzner - Division of Physiology, Dept of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health
T.M Murphy - Dept of Paediatrics, Duke University Medical Center, Durham, NC
P.D Paré - James Hogg iCAPTURE Centre, University of British Columbia, Vancouver
R Pellegrino - Dept of Respiratory Physiopathology, S. Croce e Carle Hospital, Cuneo, Italy
M.J Sanderson - Dept of Physiology, University of Massachusetts Medical School, Worcester, MA
R.R Schellenberg - James Hogg iCAPTURE Centre, University of British Columbia, Vancouver
C.Y Seow - James Hogg iCAPTURE Centre, University of British Columbia, Vancouver
P.S.P Silveira - Dept of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
P.G Smith - Dept of Paediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH
J Solway - Section of Pulmonary and Critical Care Medicine
N.L Stephens - Dept of Physiology, University of Manitoba, Winnipeg
P.J Sterk - Dept of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
A.G Stewart - Dept of Pharmacology, University of Melbourne, Parkville, Australia
D.D Tang - Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA
R.S Tepper - Dept of Paediatrics, Indiana University School of Medicine, Indianapolis, IN
T Tran - Dept of Physiology, University of Manitoba, Winnipeg
L Wang
Publication Details: The European respiratory journal, Vol.29(5), pp.834-860
Date published: 05/2007
Academic Unit: Clinical and Translational Research
Language: English
Resource Type: Journal article
Identifiers: 991031654578704646