Antibiotics, birth mode, and diet shape microbiome maturation during early life

Nicholas A Bokulich; Jennifer Chung; Thomas Battaglia; Nora Henderson; Melanie Jay; Huilin Li; Arnon D Lieber; Fen Wu; Guillermo I Perez-Perez; Yu Chen; William Schweizer; Xuhui Zheng; Monica Contreras; Maria Gloria Dominguez-Bello; Martin J Blaser

doi:10.1126/scitranslmed.aad7121

Back

Antibiotics, birth mode, and diet shape microbiome maturation during early life

Journal article

Open access

Peer reviewed

Antibiotics, birth mode, and diet shape microbiome maturation during early life

Nicholas A Bokulich, Jennifer Chung, Thomas Battaglia, Nora Henderson, Melanie Jay, Huilin Li, Arnon D Lieber, Fen Wu, Guillermo I Perez-Perez, Yu Chen, …

Science translational medicine, Vol.8(343), pp.343ra82-343ra82

06/15/2016

DOI: https://doi.org/10.1126/scitranslmed.aad7121

PMCID: PMC5308924

PMID: 27306664

Abstract

Anti-Bacterial Agents - therapeutic use

Cesarean Section

Delivery, Obstetric

Diet

Gastrointestinal Microbiome - drug effects

Breast Feeding

Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.

Files and links (1)

url

https://doi.org/10.1126/scitranslmed.aad7121View

Version of Record (VoR) Open

Metrics

26 Record Views

833 Times Cited - Web of Science

See more details

Details

Title: Antibiotics, birth mode, and diet shape microbiome maturation during early life
Creators: Nicholas A Bokulich - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Jennifer Chung - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Thomas Battaglia - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Nora Henderson - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Melanie Jay - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA. Department of Population Health, New York University Langone Medical Center, New York, NY 10016, USA
Huilin Li - Division of Biostatistics, Department of Population Health and Department of Environmental Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Arnon D Lieber - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Fen Wu - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA. Department of Population Health, New York University Langone Medical Center, New York, NY 10016, USA
Guillermo I Perez-Perez - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA. Department of Microbiology, New York University Langone Medical Center, New York, NY 10016, USA
Yu Chen - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA. Department of Population Health, New York University Langone Medical Center, New York, NY 10016, USA
William Schweizer - Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY 10016, USA
Xuhui Zheng - Department of Microbiology, New York University Langone Medical Center, New York, NY 10016, USA
Monica Contreras - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Maria Gloria Dominguez-Bello - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
Martin J Blaser - Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA. Department of Microbiology, New York University Langone Medical Center, New York, NY 10016, USA. New York Harbor Department of Veterans Affairs Medical Center, New York, NY 10010, USA. martin.blaser@nyumc.org
Publication Details: Science translational medicine, Vol.8(343), pp.343ra82-343ra82
Date published: 06/15/2016
Grant note: R01 DK090989 / NIDDK NIH HHS P30 CA016087 / NCI NIH HHS T32 AI007180 / NIAID NIH HHS
Academic Unit: Center for Advanced Biotechnology and Medicine; Biochemistry and Microbiology (SEBS)
Language: English
Resource Type: Journal article
Identifiers: 991031665711204646