Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women

Christine B Ambrosone; Gary R Zirpoli; Dana Howard Bovbjerg; Jyoti Shankar; Chi-Chen Hong; Susan E McCann; Melanie Ruszczyk; Thaer Khoury; Song Yao; Gregory L Ciupak; Lina Jandorf; Karen S Pawlish; Elisa V Bandera

doi:10.1158/1055-9965.EPI-14-0110

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Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women

Journal article

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Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women

Christine B Ambrosone, Gary R Zirpoli, Dana Howard Bovbjerg, Jyoti Shankar, Chi-Chen Hong, Susan E McCann, Melanie Ruszczyk, Thaer Khoury, Song Yao, Gregory L Ciupak, …

Cancer epidemiology, biomarkers & prevention, Vol.23(6), pp.1115-1120

06/2014

DOI: https://doi.org/10.1158/1055-9965.EPI-14-0110

PMCID: PMC4058775

PMID: 24718280

Abstract

Adult

African Americans - genetics

Breast Neoplasms - epidemiology

Breast Neoplasms - genetics

European Continental Ancestry Group - genetics

Female

Genetic Predisposition to Disease

Humans

Middle Aged

Prognosis

Reproduction - genetics

Risk Factors

The effects of reproductive factors on breast cancer risk seem to differ by estrogen receptor (ER) status. Menarche and first live birth (FLB) tend to occur at younger ages in African Americans (AA) than European Americans (EA), and could play a role in breast cancer disparities. In the Women's Circle of Health Study, a case-control study of breast cancer in EA and AA women, in-person interviews were conducted to collect epidemiologic data, including reproductive histories. Data on ER status, abstracted from pathology reports, were available for 814 AA and 538 EA breast cancer cases, and were analyzed with 1015 AA and 715 EA controls, to evaluate associations between subgroups and age at menarche, age at FLB, and the interval between those ages. Among AA women, later age at menarche (≥14 years) was associated with reduced risk of both ER(+) and ER(-) breast cancer, with ORs strongest for ER(-) disease [OR = 0.57; 95% confidence interval (CI), 0.37-0.88]; associations were weaker and nonsignificant for EA women. There were no significant associations with age at FLB, but AA women with a FLB within 15 years of menarche had increased risk of ER(-) disease (OR = 2.26; 95% CI, 1.29-3.95), with no significant associations among EAs. In our data, earlier age at menarche and shorter intervals until FLB are associated with ER(-) breast cancer in AA women; differential distributions by race of these and other reproductive risk factors could contribute to the higher prevalence of ER(-) breast cancer in AA women. Cancer Epidemiol Biomarkers Prev; 23(6); 1115-20. ©2014 AACR.

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Title: Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women
Creators: Christine B Ambrosone - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey Christine.ambrosone@roswellpark.org
Gary R Zirpoli - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Dana Howard Bovbjerg - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Jyoti Shankar - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New JerseyAuthors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Chi-Chen Hong - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Susan E McCann - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Melanie Ruszczyk - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Thaer Khoury - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Song Yao - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Gregory L Ciupak - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Lina Jandorf - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Karen S Pawlish - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Elisa V Bandera - Authors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New JerseyAuthors' Affiliations: Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo; Icahn School of Medicine at Mount Sinai, New York, New York; University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania; J. Craig Venter Institute, Rockville, Maryland; New Jersey State Cancer Registry, New Jersey Department of Health, Trenton; Rutgers Cancer Institute of New Jersey, New Brunswick; and Rutgers School of Public Health, Piscataway, New Jersey
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.23(6), pp.1115-1120
Date published: 06/2014
Grant note: K22 CA138563 / NCI NIH HHS U58 DP003931 / NCCDPHP CDC HHS P30 CA016056 / NCI NIH HHS P30 CA072720 / NCI NIH HHS R01 CA100598 / NCI NIH HHS P01 CA151135 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665592704646