Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds

Matthew Bruni; Judy F Flax; Steven Buyske; Amber D Shindhelm; Caroline Witton; Linda M Brzustowicz; Christopher W Bartlett

doi:10.1007/s10519-016-9821-3

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Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds

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Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds

Matthew Bruni, Judy F Flax, Steven Buyske, Amber D Shindhelm, Caroline Witton, Linda M Brzustowicz and Christopher W Bartlett

Behavior genetics, Vol.47(2), pp.193-201

03/2017

DOI: https://doi.org/10.1007/s10519-016-9821-3

PMCID: PMC5305590

PMID: 27826669

Abstract

Acoustic Stimulation

Auditory Threshold - physiology

Bayes Theorem

Dyslexia - genetics

Dyslexia - psychology

Family

Female

Genetics, Behavioral - methods

Humans

Male

Molecular Biology - methods

Pedigree

Reading

Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h = 0.20) and FM (h = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.

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Title: Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds
Creators: Matthew Bruni - The Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA
Judy F Flax - Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers The State University of New Jersey, Piscataway, NJ, USA
Steven Buyske - Department of Statistics, Rutgers The State University of New Jersey, Piscataway, NJ, USA
Amber D Shindhelm - The Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA
Caroline Witton - Aston Brain Centre, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
Linda M Brzustowicz - Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers The State University of New Jersey, Piscataway, NJ, USA
Christopher W Bartlett - Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital & The Ohio State University, 575 Children's Crossroad, Columbus, OH, 43205, USA. bartletc@ccri.net
Publication Details: Behavior genetics, Vol.47(2), pp.193-201
Date published: 03/2017
Grant note: R01 MH070366 / NIMH NIH HHS RC1 MH088288 / NIMH NIH HHS U24 MH068457 / NIMH NIH HHS R01 DC009453 / NIDCD NIH HHS
Academic Unit: Center for Molecular and Behavioral Neuroscience; Genetics (SAS); Statistics (SAS); Human Genetics Institute of New Jersey
Language: English
Resource Type: Journal article
Identifiers: 991031664393704646