Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Rikki Cannioto; Michael J LaMonte; Harvey A Risch; Chi-Chen Hong; Lara E Sucheston-Campbell; Kevin H Eng; J Brian Szender; Jenny Chang-Claude; Barbara Schmalfeldt; Ruediger Klapdor; Emily Gower; Albina N Minlikeeva; Gary R Zirpoli; Elisa V Bandera; Andrew Berchuck; Daniel Cramer; Jennifer A Doherty; Robert P Edwards; Brooke L Fridley; Ellen L Goode; Marc T Goodman; Estrid Hogdall; Satoyo Hosono; Allan Jensen; Susan Jordan; Susanne K Kjaer; Keitaro Matsuo; Roberta B Ness; Catherine M Olsen; Sara H Olson; Celeste Leigh Pearce; Malcolm C Pike; Mary Anne Rossing; Elizabeth A Szamreta; Pamela J Thompson; Chiu-Chen Tseng; Robert A Vierkant; Penelope M Webb; Nicolas Wentzensen; Kristine G Wicklund; Stacey J Winham; Anna H Wu; Francesmary Modugno; Joellen M Schildkraut; Kathryn L Terry; Linda E Kelemen; Kirsten B Moysich; Australian Ovarian Cancer Study Group

doi:10.1158/1055-9965.EPI-15-1330

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Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

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Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium

Rikki Cannioto, Michael J LaMonte, Harvey A Risch, Chi-Chen Hong, Lara E Sucheston-Campbell, Kevin H Eng, J Brian Szender, Jenny Chang-Claude, Barbara Schmalfeldt, Ruediger Klapdor, …

Cancer epidemiology, biomarkers & prevention, Vol.25(7), pp.1114-1124

07/2016

DOI: https://doi.org/10.1158/1055-9965.EPI-15-1330

PMCID: PMC4930728

PMID: 27197285

Abstract

Adult

Carcinoma, Ovarian Epithelial

Case-Control Studies

Exercise

Female

Humans

Logistic Models

Neoplasms, Glandular and Epithelial - epidemiology

Neoplasms, Glandular and Epithelial - etiology

Ovarian Neoplasms - epidemiology

Ovarian Neoplasms - etiology

Recreation - physiology

Risk Factors

Sedentary Behavior

Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease. Cancer Epidemiol Biomarkers Prev; 25(7); 1114-24. ©2016 AACR.

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Title: Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium
Creators: Rikki Cannioto - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
Michael J LaMonte - Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut
Chi-Chen Hong - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
Lara E Sucheston-Campbell - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
Kevin H Eng - Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York
J Brian Szender - Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York
Jenny Chang-Claude - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Barbara Schmalfeldt - Department of Gynecology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Ruediger Klapdor - Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Niedersachsen, Germany
Emily Gower - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York. Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York
Albina N Minlikeeva - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York. Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York
Gary R Zirpoli - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
Elisa V Bandera - Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
Daniel Cramer - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
Jennifer A Doherty - Department of Epidemiology, The Geisel School of Medicine at Dartmouth Medical, Hanover, New Hampshire
Robert P Edwards - Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Brooke L Fridley - Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas
Ellen L Goode - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota
Marc T Goodman - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California
Estrid Hogdall - Department of Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Allan Jensen - Department of Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Susan Jordan - Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Susanne K Kjaer - Department of Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Keitaro Matsuo - Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Roberta B Ness - The University of Texas School of Public Health, Houston, Texas
Catherine M Olsen - Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
Celeste Leigh Pearce - Department of Epidemiology, University of Michigan, Ann Arbor, Michigan
Malcolm C Pike - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
Elizabeth A Szamreta - Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Pamela J Thompson - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California
Chiu-Chen Tseng - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
Robert A Vierkant - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota
Penelope M Webb - Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland
Kristine G Wicklund - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
Stacey J Winham - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California
Francesmary Modugno - Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
Joellen M Schildkraut - Department of Public Health Sciences, The University of Virginia, Charlottesville, Virginia
Kathryn L Terry - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
Linda E Kelemen - Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York. kirsten.moysich@roswellpark.org
Australian Ovarian Cancer Study Group
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.25(7), pp.1114-1124
Date published: 07/2016
Grant note: R03 CA113148 / NCI NIH HHS N01 CN025403 / NCI NIH HHS K22 CA138563 / NCI NIH HHS R25 CA113951 / NCI NIH HHS R03 CA115195 / NCI NIH HHS K07 CA095666 / NCI NIH HHS R01 CA112523 / NCI NIH HHS R01 CA058598 / NCI NIH HHS P01 CA017054 / NCI NIH HHS P50 CA159981 / NCI NIH HHS R01 CA080742 / NCI NIH HHS UL1 TR001863 / NCATS NIH HHS P50 CA105009 / NCI NIH HHS R01 CA083918 / NCI NIH HHS R01 CA074850 / NCI NIH HHS R01 CA188900 / NCI NIH HHS N01 PC067010 / NCI NIH HHS R01 CA054419 / NCI NIH HHS R01 CA095023 / NCI NIH HHS K07 CA080668 / NCI NIH HHS P30 CA046592 / NCI NIH HHS P30 CA008748 / NCI NIH HHS R01 CA087538 / NCI NIH HHS R01 CA122443 / NCI NIH HHS P30 CA016359 / NCI NIH HHS P30 CA014089 / NCI NIH HHS K01 LM012100 / NLM NIH HHS P30 CA072720 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665349304646