Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Camilla Praestegaard; Allan Jensen; Signe M Jensen; Thor S S Nielsen; Penelope M Webb; Christina M Nagle; Anna DeFazio; Estrid Høgdall; Mary Anne Rossing; Jennifer A Doherty; Kristine G Wicklund; Marc T Goodman; Francesmary Modugno; Kirsten Moysich; Roberta B Ness; Robert Edwards; Keitaro Matsuo; Satoyo Hosono; Ellen L Goode; Stacey J Winham; Brooke L Fridley; Daniel W Cramer; Kathryn L Terry; Joellen M Schildkraut; Andrew Berchuck; Elisa V Bandera; Lisa E Paddock; Leon F Massuger; Nicolas Wentzensen; Paul Pharoah; Honglin Song; Alice Whittemore; Valerie McGuire; Weiva Sieh; Joseph Rothstein; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A Gayther; Susan J Ramus; Alexandra Gentry-Maharaj; Anna H Wu; Celeste L Pearce; Malcolm Pike; Alice W Lee; Rebecca Sutphen; Jenny Chang-Claude; Harvey A Risch; Susanne K Kjaer; Australian Ovarian Cancer Study Group

doi:10.1002/ijc.30600

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Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Journal article

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Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies

Camilla Praestegaard, Allan Jensen, Signe M Jensen, Thor S S Nielsen, Penelope M Webb, Christina M Nagle, Anna DeFazio, Estrid Høgdall, Mary Anne Rossing, Jennifer A Doherty, …

International journal of cancer, Vol.140(11), pp.2422-2435

06/01/2017

DOI: https://doi.org/10.1002/ijc.30600

PMCID: PMC5489656

PMID: 28063166

Abstract

Adult

Aged

Aged, 80 and over

Carcinoma, Ovarian Epithelial

Case-Control Studies

Female

Humans

Middle Aged

Neoplasms, Glandular and Epithelial - mortality

Ovarian Neoplasms - mortality

Proportional Hazards Models

Risk Factors

Smoking - adverse effects

Tobacco - adverse effects

Young Adult

Cigarette smoking is associated with an increased risk of developing mucinous ovarian tumors but whether it is associated with ovarian cancer survival overall or for the different histotypes is unestablished. Furthermore, it is unknown whether the association between cigarette smoking and survival differs according to strata of ovarian cancer stage at diagnosis. In a large pooled analysis, we evaluated the association between various measures of cigarette smoking and survival among women with epithelial ovarian cancer. We obtained data from 19 case-control studies in the Ovarian Cancer Association Consortium (OCAC), including 9,114 women diagnosed with ovarian cancer. Cox regression models were used to estimate adjusted study-specific hazard ratios (HRs), which were combined into pooled hazard ratios (pHR) with corresponding 95% confidence intervals (CIs) under random effects models. Overall, 5,149 (57%) women died during a median follow-up period of 7.0 years. Among women diagnosed with ovarian cancer, both current (pHR = 1.17, 95% CI: 1.08-1.28) and former smokers (pHR = 1.10, 95% CI: 1.02-1.18) had worse survival compared with never smoking women. In histotype-stratified analyses, associations were observed for mucinous (current smoking: pHR = 1.91, 95% CI: 1.01-3.65) and serous histotypes (current smoking: pHR = 1.11, 95% CI: 1.00-1.23; former smoking: pHR = 1.12, 95% CI: 1.04-1.20). Further, our results suggested that current smoking has a greater impact on survival among women with localized than disseminated disease. The identification of cigarette smoking as a modifiable factor associated with survival has potential clinical importance as a focus area to improve ovarian cancer prognosis.

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Title: Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies
Creators: Camilla Praestegaard - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Allan Jensen - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Signe M Jensen - Statistics, Bioinformatics and Registry, Danish Cancer Society Research Center, Copenhagen, Denmark
Thor S S Nielsen - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Penelope M Webb - Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
Christina M Nagle - Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
Anna DeFazio - Department of Gynecological Oncology, Westmead Hospital, Westmead, NSW, Australia
Estrid Høgdall - Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Mary Anne Rossing - Department of Epidemiology, University of Washington, Seattle, WA
Jennifer A Doherty - Department of Epidemiology, The Geisel School of Medicine, Dartmouth College, Hanover, NH
Kristine G Wicklund - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA
Marc T Goodman - Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA
Francesmary Modugno - Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA
Kirsten Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
Roberta B Ness - School of Public Health, The University of Texas, Houston, TX
Robert Edwards - Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA
Keitaro Matsuo - Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research institute, Nagoya, Aichi, Japan
Ellen L Goode - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN
Stacey J Winham - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
Brooke L Fridley - University of Kansas Medical Center, Kansas City, KS
Daniel W Cramer - Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA
Kathryn L Terry - Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA
Joellen M Schildkraut - Department of Public Health Science, School of Medicine, University of Virginia, Charlottesville, VA
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC
Elisa V Bandera - Rutgers School of Public Health, Piscataway, NJ
Lisa E Paddock - School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, NJ
Leon F Massuger - Department of Gynaecology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD
Paul Pharoah - Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge, United Kingdom
Honglin Song - Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge, United Kingdom
Alice Whittemore - Departments of Health Research & Policy and of Biomedical Data Science, Stanford School of Medicine, Stanford, CA
Valerie McGuire - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA
Weiva Sieh - Departments of Population Health Science & Policy and of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
Joseph Rothstein - Departments of Population Health Science & Policy and of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
Hoda Anton-Culver - Department of Epidemiology, Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA
Argyrios Ziogas - Department of Epidemiology, University of California Irvine, Irvine, CA
Usha Menon - Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom
Simon A Gayther - Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA
Susan J Ramus - The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Alexandra Gentry-Maharaj - Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA
Celeste L Pearce - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI
Malcolm Pike - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
Alice W Lee - Department of Health Science, California State University, Fullerton, CA
Rebecca Sutphen - Epidemiology Center, College of Medicine, University of South Florida, Tampa, FL
Jenny Chang-Claude - University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT
Susanne K Kjaer - Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Australian Ovarian Cancer Study Group
Publication Details: International journal of cancer, Vol.140(11), pp.2422-2435
Date published: 06/01/2017
Grant note: R03 CA113148 / NCI NIH HHS N01 CN025403 / NCI NIH HHS Department of Health R01 CA058860 / NCI NIH HHS C490/A10119 / Cancer Research UK K22 CA138563 / NCI NIH HHS U58 DP003931 / NCCDPHP CDC HHS R03 CA115195 / NCI NIH HHS K07 CA095666 / NCI NIH HHS P30 CA015083 / NCI NIH HHS R01 CA106414 / NCI NIH HHS R01 CA112523 / NCI NIH HHS U01 CA069417 / NCI NIH HHS R01 CA058598 / NCI NIH HHS 10124 / Cancer Research UK M01 RR000056 / NCRR NIH HHS P01 CA017054 / NCI NIH HHS P50 CA159981 / NCI NIH HHS C490/A10124 / Cancer Research UK R01 CA080742 / NCI NIH HHS R01 AG061132 / NIA NIH HHS P50 CA105009 / NCI NIH HHS P30 ES007048 / NIEHS NIH HHS P30 CA076292 / NCI NIH HHS R01 CA074850 / NCI NIH HHS R01 CA188900 / NCI NIH HHS N01 PC067010 / NCI NIH HHS R01 CA054419 / NCI NIH HHS K07 CA080668 / NCI NIH HHS R01 CA076016 / NCI NIH HHS K07 CA092044 / NCI NIH HHS K07 CA143047 / NCI NIH HHS P30 CA016056 / NCI NIH HHS HHSN261201300021C / NCI NIH HHS R01 CA087538 / NCI NIH HHS P50 CA136393 / NCI NIH HHS R01 CA122443 / NCI NIH HHS P30 CA016359 / NCI NIH HHS P30 CA014089 / NCI NIH HHS P30 CA072720 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665526504646