Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers

Kim M Hirshfield; Denis Tolkunov; Hua Zhong; Siraj M Ali; Mark N Stein; Susan Murphy; Hetal Vig; Alexei Vazquez; John Glod; Rebecca A Moss; Vladimir Belyi; Chang S Chan; Suzie Chen; Lauri Goodell; David Foran; Roman Yelensky; Norma A Palma; James X Sun; Vincent A Miller; Philip J Stephens; Jeffrey S Ross; Howard Kaufman; Elizabeth Poplin; Janice Mehnert; Antoinette R Tan; Joseph R Bertino; Joseph Aisner; Robert S DiPaola; Lorna Rodriguez-Rodriguez; Shridar Ganesan

doi:10.1634/theoncologist.2016-0049

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$Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers$

Journal article

Open access

Peer reviewed

Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers

Kim M Hirshfield, Denis Tolkunov, Hua Zhong, Siraj M Ali, Mark N Stein, Susan Murphy, Hetal Vig, Alexei Vazquez, John Glod, Rebecca A Moss, …

The oncologist (Dayton, Ohio), Vol.21(11), pp.1315-1325

11/2016

DOI: https://doi.org/10.1634/theoncologist.2016-0049

PMCID: PMC5189630

PMID: 27566247

Abstract

Molecular targeted therapy

Cancer Diagnostics and Molecular Pathology

Molecular sequencing

Tumor genomics

Cancer

Mutation

To study the frequency with which targeted tumor sequencing results will lead to implemented change in care, this study assessed tumors from 100 patients for utility, feasibility, and limitations of genomic sequencing for genomically guided therapy or other clinical purpose in the setting of a multidisciplinary molecular tumor board. Comprehensive profiling led to implementable clinical action in 35% of tumors with genomic alterations.

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Title: Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers
Creators: Kim M Hirshfield - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Denis Tolkunov - Department of Clinical Informatics, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Hua Zhong - Department of Pathology and Laboratory Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Siraj M Ali - Foundation Medicine, Cambridge, Massachusetts, USA
Mark N Stein - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Susan Murphy - Department of Pediatrics, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Hetal Vig - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Alexei Vazquez - Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
John Glod - Department of Pediatrics, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Rebecca A Moss - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Vladimir Belyi - Department of Clinical Informatics, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Chang S Chan - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Suzie Chen - Department of Chemical Biology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA
Lauri Goodell - Department of Pathology and Laboratory Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
David Foran - Department of Pathology and Laboratory Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Roman Yelensky - Foundation Medicine, Cambridge, Massachusetts, USA
Norma A Palma - Foundation Medicine, Cambridge, Massachusetts, USA
James X Sun - Foundation Medicine, Cambridge, Massachusetts, USA
Vincent A Miller - Foundation Medicine, Cambridge, Massachusetts, USA
Philip J Stephens - Foundation Medicine, Cambridge, Massachusetts, USA
Jeffrey S Ross - Foundation Medicine, Cambridge, Massachusetts, USA
Howard Kaufman - Division of Surgical Oncology, Department of Surgery, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Elizabeth Poplin - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Janice Mehnert - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Antoinette R Tan - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Joseph R Bertino - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Joseph Aisner - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Robert S DiPaola - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Lorna Rodriguez-Rodriguez - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Shridar Ganesan - Division of Medical Oncology, Department of Medicine, Rutgers Cancer Institute of New Jersey/Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Publication Details: The oncologist (Dayton, Ohio), Vol.21(11), pp.1315-1325
Date published: 11/2016
Publisher: AlphaMed Press
Academic Unit: Gastrointestinal Oncology Program; Pathology and Laboratory Medicine (RWJMS); Molecular Oncology; Lung Cancer/Thoracic Oncology Program; Center for Systems and Computational Biology; Biomedical Informatics; Chemical Biology (EMSOP); Pediatric Hematology/Oncology Program; Bertino Office
Language: English
Resource Type: Journal article
Identifiers: 991031654496104646