Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

Ganna Chornokur; Hui-Yi Lin; Jonathan P Tyrer; Kate Lawrenson; Joe Dennis; Ernest K Amankwah; Xiaotao Qu; Ya-Yu Tsai; Heather S L Jim; Zhihua Chen; Ann Y Chen; Jennifer Permuth-Wey; Katja K H Aben; Hoda Anton-Culver; Natalia Antonenkova; Fiona Bruinsma; Elisa V Bandera; Yukie T Bean; Matthias W Beckmann; Maria Bisogna; Line Bjorge; Natalia Bogdanova; Louise A Brinton; Angela Brooks-Wilson; Clareann H Bunker; Ralf Butzow; Ian G Campbell; Karen Carty; Jenny Chang-Claude; Linda S Cook; Daniel W Cramer; Julie M Cunningham; Cezary Cybulski; Agnieszka Dansonka-Mieszkowska; Andreas du Bois; Evelyn Despierre; Ed Dicks; Jennifer A Doherty; Thilo Dörk; Matthias Dürst; Douglas F Easton; Diana M Eccles; Robert P Edwards; Arif B Ekici; Peter A Fasching; Brooke L Fridley; Yu-Tang Gao; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind Glasspool; Marc T Goodman; Jacek Gronwald; Patricia Harrington; Philipp Harter; Alexander Hein; Florian Heitz; Michelle A T Hildebrandt; Peter Hillemanns; Claus K Hogdall; Estrid Hogdall; Satoyo Hosono; Anna Jakubowska; Allan Jensen; Bu-Tian Ji; Beth Y Karlan; Linda E Kelemen; Mellissa Kellar; Lambertus A Kiemeney; Camilla Krakstad; Susanne K Kjaer; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Nhu D Le; Alice W Lee; Shashi Lele; Arto Leminen; Jenny Lester; Douglas A Levine; Dong Liang; Boon Kiong Lim; Jolanta Lissowska; Karen Lu; Jan Lubinski; Lene Lundvall; Leon F A G Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Iain McNeish; Usha Menon; Roger L Milne; Francesmary Modugno; Kirsten B Moysich; Roberta B Ness; Heli Nevanlinna; Ursula Eilber; Kunle Odunsi; Sara H Olson; Irene Orlow; Sandra Orsulic; Rachel Palmieri Weber; James Paul; Celeste L Pearce; Tanja Pejovic; Liisa M Pelttari; Malcolm C Pike; Elizabeth M Poole; Harvey A Risch; Barry Rosen; Mary Anne Rossing; Joseph H Rothstein; Anja Rudolph; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Eva Schernhammer; Ira Schwaab; Xiao-Ou Shu; Yurii B Shvetsov; Nadeem Siddiqui; Weiva Sieh; Honglin Song; Melissa C Southey; Beata Spiewankiewicz; Lara Sucheston; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Lotte Thomsen; Ingvild L Tangen; Shelley S Tworoger; Anne M van Altena; Robert A Vierkant; Ignace Vergote; Christine S Walsh; Shan Wang-Gohrke; Nicolas Wentzensen; Alice S Whittemore; Kristine G Wicklund; Lynne R Wilkens; Anna H Wu; Xifeng Wu; Yin-Ling Woo; Hannah Yang; Wei Zheng; Argyrios Ziogas; Hanis N Hasmad; Andrew Berchuck; Edwin S Iversen; Joellen M Schildkraut; Susan J Ramus; Ellen L Goode; Alvaro N A Monteiro; Simon A Gayther; Steven A Narod; Paul D P Pharoah; Thomas A Sellers; Catherine M Phelan; AOCS management group

doi:10.1371/journal.pone.0128106

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Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

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Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

Ganna Chornokur, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ernest K Amankwah, Xiaotao Qu, Ya-Yu Tsai, Heather S L Jim, Zhihua Chen, …

PloS one, Vol.10(6), pp.e0128106-e0128106

2015

DOI: https://doi.org/10.1371/journal.pone.0128106

PMCID: PMC4474865

PMID: 26091520

Abstract

Alleles

Biological Transport

Carcinoma, Ovarian Epithelial

Carrier Proteins - genetics

Carrier Proteins - metabolism

Case-Control Studies

Female

Genetic Association Studies

Genetic Predisposition to Disease

Genetic Variation

Humans

Neoplasms, Glandular and Epithelial - epidemiology

Neoplasms, Glandular and Epithelial - genetics

Neoplasms, Glandular and Epithelial - pathology

Odds Ratio

Ovarian Neoplasms - epidemiology

Ovarian Neoplasms - genetics

Ovarian Neoplasms - pathology

Polymorphism, Single Nucleotide

Risk

African Americans

Asian Americans

Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q<0.2 was applied to adjust for multiple comparisons. The most significant evidence of an association for all invasive cancers combined and for the serous subtype was observed for SNP rs17216603 in the iron transporter gene HEPH (invasive: OR = 0.85, P = 0.00026; serous: OR = 0.81, P = 0.00020); this SNP was also associated with the borderline/low malignant potential (LMP) tumors (P = 0.021). Other genes significantly associated with EOC histological subtypes (p<0.05) included the UGT1A (endometrioid), SLC25A45 (mucinous), SLC39A11 (low malignant potential), and SERPINA7 (clear cell carcinoma). In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A) were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects. The most significant imputed SNP was rs117729793 in SLC39A11 (per allele, OR = 2.55, 95% CI = 1.5-4.35, p = 5.66x10-4). These results, generated on a large cohort of women, revealed associations between inherited cellular transport gene variants and risk of EOC histologic subtypes.

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Title: Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk
Creators: Ganna Chornokur - Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Hui-Yi Lin - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Jonathan P Tyrer - Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Kate Lawrenson - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Joe Dennis - Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Ernest K Amankwah - Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America; Clinical and Translational Research Organization, All Children's Hospital Johns Hopkins Medicine, St Petersburg, Florida, United States of America
Xiaotao Qu - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Ya-Yu Tsai - Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Heather S L Jim - Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, United States of America
Zhihua Chen - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Ann Y Chen - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Jennifer Permuth-Wey - Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Katja K H Aben - Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands; Comprehensive Cancer Center The Netherlands, Nijmegen, The Netherlands
Hoda Anton-Culver - Genetic Epidemiology Research Institute, Center for Cancer Genetics Research and Prevention, University of California Irvine, Irvine, California, United States of America
Natalia Antonenkova - N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus
Fiona Bruinsma - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
Elisa V Bandera - Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
Yukie T Bean - Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America
Matthias W Beckmann - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany
Maria Bisogna - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Line Bjorge - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Natalia Bogdanova - Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Angela Brooks-Wilson - Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada
Clareann H Bunker - Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
Ralf Butzow - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland; Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
Ian G Campbell - Cancer Genetics Laboratory Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia; Department of Pathology, the University of Melbourne, Parkville, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia
Karen Carty - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom; The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Jenny Chang-Claude - German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Linda S Cook - Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America
Daniel W Cramer - Obstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
Cezary Cybulski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Agnieszka Dansonka-Mieszkowska - Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Andreas du Bois - Department of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany; Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Evelyn Despierre - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Ed Dicks - Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Jennifer A Doherty - Department of Epidemiology, The Geisel School of Medicine Hanover, New Hampshire, United States of America; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
Thilo Dörk - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
Matthias Dürst - Department of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
Douglas F Easton - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Diana M Eccles - Faculty of Medicine, University of Southampton, Southampton, United Kingdom
Robert P Edwards - Ovarian Cancer Center of Excellence, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
Arif B Ekici - Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany
Peter A Fasching - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany; University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California, United States of America
Brooke L Fridley - Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Yu-Tang Gao - Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Aleksandra Gentry-Maharaj - Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom
Graham G Giles - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia
Rosalind Glasspool - The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Marc T Goodman - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America; Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Jacek Gronwald - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Patricia Harrington - Department of Oncology, The Centre for Cancer Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom
Philipp Harter - Department of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany; Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Alexander Hein - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Erlangen, Germany
Florian Heitz - Department of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany; Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Michelle A T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Peter Hillemanns - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
Claus K Hogdall - The Juliane Marie Centre, Department of Gynecology, Righospitalet, University of Copenhagen, Copenhagen, Denmark
Estrid Hogdall - Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Satoyo Hosono - Department of Preventive Medicine, Kyushu University Faculty of Medical Science, Nagoya, Aichi, Japan
Anna Jakubowska - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Allan Jensen - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Bu-Tian Ji - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Linda E Kelemen - Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
Mellissa Kellar - Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America
Lambertus A Kiemeney - Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands
Camilla Krakstad - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Susanne K Kjaer - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Jolanta Kupryjanczyk - Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Diether Lambrechts - Vesalius Research Center, VIB, Leuven, Belgium; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium
Sandrina Lambrechts - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Nhu D Le - Cancer Control Research, BC Cancer Agency, Vancouver, Canada
Alice W Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Shashi Lele - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Arto Leminen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland
Jenny Lester - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Douglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, United States of America
Boon Kiong Lim - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Karen Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Jan Lubinski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Lene Lundvall - The Juliane Marie Centre, Department of Gynecology, Righospitalet, University of Copenhagen, Copenhagen, Denmark
Leon F A G Massuger - Department of Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands
Keitaro Matsuo - Department of Preventive Medicine, Kyushu University Faculty of Medical Science, Nagoya, Aichi, Japan
Valerie McGuire - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
John R McLaughlin - Public Health Ontario, Toronto, Canada
Iain McNeish - Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer research Centre, Beatson Institute for Cancer Research, Glasgow, UK
Usha Menon - Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom
Roger L Milne - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
Francesmary Modugno - Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America; Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Roberta B Ness - The University of Texas School of Public Health, Houston, Texas, United States of America
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland
Ursula Eilber - German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Kunle Odunsi - Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Irene Orlow - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Sandra Orsulic - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Rachel Palmieri Weber - Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
James Paul - The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Celeste L Pearce - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America; Department of Epidemiology, University of Michigan School of Public Health,Ann Arbor, Michigan, United States of America
Tanja Pejovic - Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America
Liisa M Pelttari - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland
Malcolm C Pike - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Elizabeth M Poole - Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America
Barry Rosen - Department of Gynecology-Oncology, Princess Margaret Hospital, and Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
Joseph H Rothstein - Department of Health Research and Policy- Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
Anja Rudolph - German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Ingo B Runnebaum - Department of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
Iwona K Rzepecka - Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Helga B Salvesen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Eva Schernhammer - Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Ira Schwaab - Institut für Humangenetik, Wiesbaden, Germany
Xiao-Ou Shu - Epidemiology Center and Vanderbilt, Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America
Nadeem Siddiqui - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom
Weiva Sieh - Department of Health Research and Policy- Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
Honglin Song - Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Melissa C Southey - Department of Pathology, the University of Melbourne, Parkville, Australia
Beata Spiewankiewicz - Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Lara Sucheston - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Soo-Hwang Teo - Cancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia; University Malaya Cancer Research Institute, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Maylaysia
Kathryn L Terry - Obstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Pamela J Thompson - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America; Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Lotte Thomsen - Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Ingvild L Tangen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Shelley S Tworoger - Obstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Anne M van Altena - Department of Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands
Robert A Vierkant - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
Ignace Vergote - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Christine S Walsh - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Shan Wang-Gohrke - German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Alice S Whittemore - Department of Health Research and Policy- Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
Kristine G Wicklund - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Yin-Ling Woo - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Hannah Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Wei Zheng - Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Argyrios Ziogas - Genetic Epidemiology Research Institute, Center for Cancer Genetics Research and Prevention, University of California Irvine, Irvine, California, United States of America
Hanis N Hasmad - Cancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, United States of America
Edwin S Iversen - Department of Statistics, Duke University, Durham, North Carolina, United States of America
Joellen M Schildkraut - Cancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, United States of America
Susan J Ramus - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Ellen L Goode - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, United States of America
Alvaro N A Monteiro - Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Simon A Gayther - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Steven A Narod - Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada
Paul D P Pharoah - Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Thomas A Sellers - Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Catherine M Phelan - Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
AOCS management group
Publication Details: PloS one, Vol.10(6), pp.e0128106-e0128106
Date published: 2015
Grant note: R03 CA113148 / NCI NIH HHS N01 CN025403 / NCI NIH HHS R01 CA-1491429 / NCI NIH HHS R03‐CA113148 / NCI NIH HHS K22 CA138563 / NCI NIH HHS P30 CA071789 / NCI NIH HHS Intramural NIH HHS K22‐CA138563 / NCI NIH HHS R01‐CA122443 / NCI NIH HHS R01‐CA080978 / NCI NIH HHS C490/A10124 / Cancer Research UK R01 CA067262 / NCI NIH HHS P50 CA105009 / NCI NIH HHS R01 CA074850 / NCI NIH HHS R01‐CA074850 / NCI NIH HHS R01 CA054419 / NCI NIH HHS R01‐CA136924 / NCI NIH HHS R01‐CA061107 / NCI NIH HHS R01 CA136924 / NCI NIH HHS R01 CA076016 / NCI NIH HHS K07‐CA143047 / NCI NIH HHS UL1 TR000005 / NCATS NIH HHS K07 CA143047 / NCI NIH HHS R01‐CA114343 / NCI NIH HHS R01 CA122443 / NCI NIH HHS R01‐CA017054 / NCI NIH HHS R01‐CA061132 / NCI NIH HHS R01 CA058860 / NCI NIH HHS R01‐CA014089 / NCI NIH HHS R01‐CA058860 / NCI NIH HHS R01 CA114343 / NCI NIH HHS P30 CA016672 / NCI NIH HHS P30-CA072720 / NCI NIH HHS R01 CA087696 / NCI NIH HHS C490/A6187 / Cancer Research UK R01‐CA126841 / NCI NIH HHS N01‐PC035137 / NCI NIH HHS P30 CA076292 / NCI NIH HHS R01-CA076016 / NCI NIH HHS R01‐CA054419 / NCI NIH HHS R01‐CA071766 / NCI NIH HHS R01‐CA058598 / NCI NIH HHS P01‐CA087696 / NCI NIH HHS R01 CA126841 / NCI NIH HHS P30 CA014089 / NCI NIH HHS N01-PC67001 / NCI NIH HHS R01‐CA080742 / NCI NIH HHS P30 CA072720 / NCI NIH HHS U01‐CA071966 / NCI NIH HHS T32ES013678 / NIEHS NIH HHS R03 CA115195 / NCI NIH HHS R03‐CA115195 / NCI NIH HHS MSH-87734 / Canadian Institutes of Health Research U01 CA049449 / NCI NIH HHS U01 CA069417 / NCI NIH HHS R01 CA058598 / NCI NIH HHS P01 CA017054 / NCI NIH HHS R01 CA080742 / NCI NIH HHS R01 CA083918 / NCI NIH HHS U01 CA058860 / NCI NIH HHS N01‐PC067010 / NCI NIH HHS K07 CA092044 / NCI NIH HHS R01‐CA016056 / NCI NIH HHS P30 CA016056 / NCI NIH HHS R01 CA087538 / NCI NIH HHS P01‐CA017054 / NCI NIH HHS R01‐095023 / PHS HHS N01 PC035137 / NCI NIH HHS N01‐CN55424 / NCI NIH HHS UM1 CA182910 / NCI NIH HHS T32 ES013678 / NIEHS NIH HHS U19-CA148112 / NCI NIH HHS C490/A10119 / Cancer Research UK MOP-86727 / Canadian Institutes of Health Research R01‐CA112523 / NCI NIH HHS K07‐CA095666 / NCI NIH HHS P50-CA136393 / NCI NIH HHS U01 CA067262 / NCI NIH HHS K07 CA095666 / NCI NIH HHS R01 CA112523 / NCI NIH HHS R01‐CA087538 / NCI NIH HHS R01‐CA049449 / NCI NIH HHS R21 CA179659 / NCI NIH HHS 10124 / Cancer Research UK U19 CA148112 / NCI NIH HHS N01 PC067010 / NCI NIH HHS R01 CA050385 / NCI NIH HHS R01‐CA050385 / NCI NIH HHS P30 CA008748 / NCI NIH HHS R01‐CA092044 / NCI NIH HHS R01‐CA083918 / NCI NIH HHS P50 CA136393 / NCI NIH HHS PSA-042205 / PHS HHS R01 CA049449 / NCI NIH HHS P50‐CA105009 / NCI NIH HHS R01‐CA067262 / NCI NIH HHS U01‐CA069417 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665506704646