Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

Kate Lawrenson; Edwin S Iversen; Jonathan Tyrer; Rachel Palmieri Weber; Patrick Concannon; Dennis J Hazelett; Qiyuan Li; Jeffrey R Marks; Andrew Berchuck; Janet M Lee; Katja K H Aben; Hoda Anton-Culver; Natalia Antonenkova; Elisa V Bandera; Yukie Bean; Matthias W Beckmann; Maria Bisogna; Line Bjorge; Natalia Bogdanova; Louise A Brinton; Angela Brooks-Wilson; Fiona Bruinsma; Ralf Butzow; Ian G Campbell; Karen Carty; Jenny Chang-Claude; Georgia Chenevix-Trench; Ann Chen; Zhihua Chen; Linda S Cook; Daniel W Cramer; Julie M Cunningham; Cezary Cybulski; Joanna Plisiecka-Halasa; Joe Dennis; Ed Dicks; Jennifer A Doherty; Thilo Dörk; Andreas du Bois; Diana Eccles; Douglas T Easton; Robert P Edwards; Ursula Eilber; Arif B Ekici; Peter A Fasching; Brooke L Fridley; Yu-Tang Gao; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind Glasspool; Ellen L Goode; Marc T Goodman; Jacek Gronwald; Philipp Harter; Hanis Nazihah Hasmad; Alexander Hein; Florian Heitz; Michelle A T Hildebrandt; Peter Hillemanns; Estrid Hogdall; Claus Hogdall; Satoyo Hosono; Anna Jakubowska; James Paul; Allan Jensen; Beth Y Karlan; Susanne Kruger Kjaer; Linda E Kelemen; Melissa Kellar; Joseph L Kelley; Lambertus A Kiemeney; Camilla Krakstad; Diether Lambrechts; Sandrina Lambrechts; Nhu D Le; Alice W Lee; Rikki Cannioto; Arto Leminen; Jenny Lester; Douglas A Levine; Dong Liang; Jolanta Lissowska; Karen Lu; Jan Lubinski; Lene Lundvall; Leon F A G Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Heli Nevanlinna; Iain McNeish; Usha Menon; Francesmary Modugno; Kirsten B Moysich; Steven A Narod; Lotte Nedergaard; Roberta B Ness; Mat Adenan Noor Azmi; Kunle Odunsi; Sara H Olson; Irene Orlow; Sandra Orsulic; Celeste L Pearce; Tanja Pejovic; Liisa M Pelttari; Jennifer Permuth-Wey; Catherine M Phelan; Malcolm C Pike; Elizabeth M Poole; Susan J Ramus; Harvey A Risch; Barry Rosen; Mary Anne Rossing; Joseph H Rothstein; Anja Rudolph; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Agnieszka Budzilowska; Thomas A Sellers; Xiao-Ou Shu; Yurii B Shvetsov; Nadeem Siddiqui; Weiva Sieh; Honglin Song; Melissa C Southey; Lara Sucheston; Ingvild L Tangen; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Agnieszka Timorek; Shelley S Tworoger; Els Van Nieuwenhuysen; Ignace Vergote; Robert A Vierkant; Shan Wang-Gohrke; Christine Walsh; Nicolas Wentzensen; Alice S Whittemore; Kristine G Wicklund; Lynne R Wilkens; Yin-Ling Woo; Xifeng Wu; Anna H Wu; Hannah Yang; Wei Zheng; Argyrios Ziogas; Gerhard A Coetzee; Matthew L Freedman; Alvaro N A Monteiro; Joanna Moes-Sosnowska; Jolanta Kupryjanczyk; Paul D Pharoah; Simon A Gayther; Joellen M Schildkraut; Australian Ovarian Cancer Study Group

doi:10.1093/carcin/bgv138

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Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

Journal article

Open access

Peer reviewed

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

Kate Lawrenson, Edwin S Iversen, Jonathan Tyrer, Rachel Palmieri Weber, Patrick Concannon, Dennis J Hazelett, Qiyuan Li, Jeffrey R Marks, Andrew Berchuck, Janet M Lee, …

Carcinogenesis (New York), Vol.36(11), pp.1341-1353

11/2015

DOI: https://doi.org/10.1093/carcin/bgv138

PMCID: PMC4635670

PMID: 26424751

Abstract

Carcinoma, Ovarian Epithelial

Case-Control Studies

Checkpoint Kinase 2 - genetics

Female

Genetic Loci

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Neoplasms, Glandular and Epithelial - genetics

Ovarian Neoplasms - genetics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Risk Factors

Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist. Here, we evaluated associations between common genetic variants [single nucleotide polymorphisms (SNPs) and indels] in DNA repair genes and EOC risk. We genotyped 2896 common variants at 143 gene loci in DNA samples from 15 397 patients with invasive EOC and controls. We found evidence of associations with EOC risk for variants at FANCA, EXO1, E2F4, E2F2, CREB5 and CHEK2 genes (P ≤ 0.001). The strongest risk association was for CHEK2 SNP rs17507066 with serous EOC (P = 4.74 x 10(-7)). Additional genotyping and imputation of genotypes from the 1000 genomes project identified a slightly more significant association for CHEK2 SNP rs6005807 (r (2) with rs17507066 = 0.84, odds ratio (OR) 1.17, 95% CI 1.11-1.24, P = 1.1×10(-7)). We identified 293 variants in the region with likelihood ratios of less than 1:100 for representing the causal variant. Functional annotation identified 25 candidate SNPs that alter transcription factor binding sites within regulatory elements active in EOC precursor tissues. In The Cancer Genome Atlas dataset, CHEK2 gene expression was significantly higher in primary EOCs compared to normal fallopian tube tissues (P = 3.72×10(-8)). We also identified an association between genotypes of the candidate causal SNP rs12166475 (r (2) = 0.99 with rs6005807) and CHEK2 expression (P = 2.70×10(-8)). These data suggest that common variants at 22q12.1 are associated with risk of serous EOC and CHEK2 as a plausible target susceptibility gene.

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Title: Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer
Creators: Kate Lawrenson - Present address: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA and
Edwin S Iversen - Department of Statistical Science, Duke University, Durham, NC 27708, USA
Jonathan Tyrer - Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge CB2 1TN, UK
Rachel Palmieri Weber - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
Patrick Concannon - Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA
Dennis J Hazelett - Departments of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
Qiyuan Li - Medical School, Xiamen University, Xiamen 361000, China
Jeffrey R Marks - Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
Janet M Lee
Katja K H Aben - Department for Health Evidence, Nijmegen 6500 HB, The Netherlands, Comprehensive Cancer Center, Utrecht 3542 EG, The Netherlands
Hoda Anton-Culver - Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, CA 92697, USA
Natalia Antonenkova - Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk 223052, Belarus
Elisa V Bandera - Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA
Yukie Bean - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
Matthias W Beckmann - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany
Maria Bisogna - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Line Bjorge - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway
Natalia Bogdanova - Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Angela Brooks-Wilson - Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
Fiona Bruinsma - Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne Victoria 3004, Australia
Ralf Butzow - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland, Department of Pathology, Helsinki University Central Hospital, Helsinki 00029, Finland
Ian G Campbell - Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia, Department of Pathology, University of Melbourne, Parkville, Victoria 3002, Australia, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3002, Australia
Karen Carty - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK
Jenny Chang-Claude - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69009, Germany
Georgia Chenevix-Trench - Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane Queensland 4029, Australia
Ann Chen - Department of Biostatistics, Moffitt Cancer Center, Tampa, FL 33612, USA
Zhihua Chen - Department of Biostatistics, Moffitt Cancer Center, Tampa, FL 33612, USA
Linda S Cook - Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA
Daniel W Cramer - Harvard School of Public Health, Boston, MA 02115, USA, Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Cezary Cybulski - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland
Joanna Plisiecka-Halasa - Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland
Joe Dennis - Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK
Ed Dicks - Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK
Jennifer A Doherty - Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA
Thilo Dörk - Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany
Andreas du Bois - Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA, Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany
Diana Eccles - Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton SO16 5YA, UK
Douglas T Easton - Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK
Robert P Edwards - Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton SO16 5YA, UK, Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15222, USA
Ursula Eilber - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69009, Germany
Arif B Ekici - Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany
Peter A Fasching - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, David Geffen School of Medicine, Los Angeles CA 90095, USA
Brooke L Fridley - Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, KS 66160, USA
Yu-Tang Gao - Shanghai Cancer Institute, Shanghai 200032, China
Aleksandra Gentry-Maharaj - Department of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK
Graham G Giles - Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne Victoria 3004, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria 3010, Australia
Rosalind Glasspool - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK
Ellen L Goode - Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA
Marc T Goodman - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA, Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Jacek Gronwald - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland
Philipp Harter - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen 45136, Germany, Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany
Hanis Nazihah Hasmad - Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500, Malaysia
Alexander Hein - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen 91054, Germany
Florian Heitz - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen 45136, Germany, Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany
Michelle A T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Peter Hillemanns - Departments of Obstetrics and Gynaecology, Hannover Medical School, Hannover 30625, Germany
Estrid Hogdall - Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen DK-2100, Denmark, Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen DK-2100, Denmark
Claus Hogdall - Gyn Clinic, Rigshospitalet, University of Copenhagen DK-2100, Denmark
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan
Anna Jakubowska - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland
James Paul - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK
Allan Jensen - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen DK-2100, Denmark
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Susanne Kruger Kjaer - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen DK-2100, Denmark, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark
Linda E Kelemen - Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA
Melissa Kellar - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
Joseph L Kelley - Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15222, USA
Lambertus A Kiemeney - Department for Health Evidence and Department of Urology, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands
Camilla Krakstad - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway
Diether Lambrechts - Vesalius Research Center, VIB, Leuven 3000, Belgium, Laboratory for Translational Genetics, Department of Oncology, University of Leuven 3000, Belgium
Sandrina Lambrechts - Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, 3000, Belgium
Nhu D Le - Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
Alice W Lee
Rikki Cannioto - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Arto Leminen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland
Jenny Lester - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Douglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland
Karen Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Jan Lubinski - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland
Lene Lundvall - Gyn Clinic, Rigshospitalet, University of Copenhagen DK-2100, Denmark
Leon F A G Massuger - Department of Gynaecology, Radboud University Medical Centre, Nijmegen 6500 HB, The Netherlands
Keitaro Matsuo - Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan
Valerie McGuire - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA
John R McLaughlin - Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland
Iain McNeish - Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow G61 1QH, UK
Usha Menon - Department of Women's Cancer, Institute for Women's Health, University College London, London W1T 7DN, UK
Francesmary Modugno - Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15222, USA, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15222, USA, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15222, USA, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15222, USA
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Steven A Narod - Women's College Research Institute, Toronto, Ontario M5G 1N8, Canada
Lotte Nedergaard - Department of Pathology, Rigshospitalet, University of Copenhagen DK-2100, Denmark
Roberta B Ness - The University of Texas School of Public Health, Houston, TX 77225, USA
Mat Adenan Noor Azmi - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia
Kunle Odunsi - Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Irene Orlow - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Sandra Orsulic - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Celeste L Pearce - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Tanja Pejovic - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
Liisa M Pelttari - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland
Jennifer Permuth-Wey - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA
Catherine M Phelan - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA
Malcolm C Pike - Department of Statistical Science, Duke University, Durham, NC 27708, USA, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Elizabeth M Poole - Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Susan J Ramus
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06520, USA
Barry Rosen - Department of Gynecologic-Oncology, Princess Margaret Hospital, and Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5G 1X6, Canada
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Joseph H Rothstein - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Anja Rudolph - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69009, Germany
Ingo B Runnebaum - Department of Gynecology, Jena University Hospital - Friedrich Schiller University, Jena D-07743, Germany
Iwona K Rzepecka - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 70-115, Poland
Helga B Salvesen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway
Agnieszka Budzilowska - Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland
Thomas A Sellers - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA
Xiao-Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii 96826, USA
Nadeem Siddiqui - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK
Weiva Sieh - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Honglin Song - Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge CB2 1TN, UK
Melissa C Southey - Department of Pathology, University of Melbourne, Parkville, Victoria 3002, Australia
Lara Sucheston - College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
Ingvild L Tangen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen 5020, Norway
Soo-Hwang Teo - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia
Kathryn L Terry - Harvard School of Public Health, Boston, MA 02115, USA, Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Pamela J Thompson - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA, Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Agnieszka Timorek - Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw 03-242, Poland
Shelley S Tworoger - Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Els Van Nieuwenhuysen - Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, 3000, Belgium
Ignace Vergote - Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, 3000, Belgium
Robert A Vierkant - Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA
Shan Wang-Gohrke - Department of Obstetrics and Gynecology, University of Ulm, Ulm 89075, Germany
Christine Walsh - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Alice S Whittemore - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Kristine G Wicklund - Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii 96826, USA
Yin-Ling Woo - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia, University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur 50603, Malaysia
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Anna H Wu
Hannah Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Wei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Argyrios Ziogas - Comprehensive Cancer Center, Utrecht 3542 EG, The Netherlands
Gerhard A Coetzee - Departments of Urology and Preventive Medicine, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
Matthew L Freedman - Department of Medical Oncology, 02115, Dana-Farber Cancer Institute, Boston, MA, USA
Alvaro N A Monteiro - Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA and
Joanna Moes-Sosnowska - Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland
Jolanta Kupryjanczyk - Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02-781, Poland
Paul D Pharoah - Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory, Cambridge CB2 1TN, UK
Simon A Gayther - Present address: Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Joellen M Schildkraut - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA, Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC 27710, USA, jms2yf@virginia.edu
Australian Ovarian Cancer Study Group
Publication Details: Carcinogenesis (New York), Vol.36(11), pp.1341-1353
Date published: 11/2015
Grant note: K22-CA138563 / NCI NIH HHS R01-CA76016 / NCI NIH HHS R01-CA95023 / NCI NIH HHS R01-CA122443 / NCI NIH HHS M01-RR000056 / NCRR NIH HHS P30 CA071789 / NCI NIH HHS R01-CA080742 / NCI NIH HHS R01-CA074850 / NCI NIH HHS R01-CA83918 / NCI NIH HHS N01-CN025403 / NCI NIH HHS P30-CA14089 / NCI NIH HHS R01-CA092044 / NCI NIH HHS R03-CA115195 / NCI NIH HHS R01-CA61132 / NCI NIH HHS P01 CA087969 / NCI NIH HHS R01-CA87538 / NCI NIH HHS P50-CA105009 / NCI NIH HHS R01-CA063678 / NCI NIH HHS K07-CA080668 / NCI NIH HHS O01-CA71966 / NCI NIH HHS K07-CA095666 / NCI NIH HHS UM1 CA182910 / NCI NIH HHS R01-CA54419 / NCI NIH HHS R01-CA058860 / NCI NIH HHS U19-CA148112 / NCI NIH HHS 1K99CA184415-01 / NCI NIH HHS UM1-CA182910 / NCI NIH HHS R01-CA126841 / NCI NIH HHS P50-CA136393 / NCI NIH HHS P30 CA015083 / NCI NIH HHS R01 CA114343 / NCI NIH HHS P30-CA072720 / NCI NIH HHS 10124 / Cancer Research UK R01-CA58598 / NCI NIH HHS UL1 TR000124 / NCATS NIH HHS P30 CA076292 / NCI NIH HHS P01-CA17054 / NCI NIH HHS N01-CN55424 / NCI NIH HHS K07-CA143047 / NCI NIH HHS UL1TR000124 / NCATS NIH HHS N01-PC67010 / NCI NIH HHS P30 CA008748 / NCI NIH HHS P50-CA159981 / NCI NIH HHS P50 CA136393 / NCI NIH HHS P30-CA15083 / NCI NIH HHS R01-CA16056 / NCI NIH HHS PSA-042205 / PHS HHS U01-CA69417 / NCI NIH HHS R03-CA113148 / NCI NIH HHS R01-CA112523 / NCI NIH HHS P30 CA014089 / NCI NIH HHS N01-PC67001 / NCI NIH HHS P30 CA072720 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031666068404646