Comprehensive T cell repertoire characterization of non-small cell lung cancer

Alexandre Reuben; Jiexin Zhang; Shin-Heng Chiou; Rachel M Gittelman; Jun Li; Won-Chul Lee; Junya Fujimoto; Carmen Behrens; Xiaoke Liu; Feng Wang; Kelly Quek; Chunlin Wang; Farrah Kheradmand; Runzhe Chen; Chi-Wan Chow; Heather Lin; Chantale Bernatchez; Ali Jalali; Xin Hu; Chang-Jiun Wu; Agda Karina Eterovic; Edwin Roger Parra; Erik Yusko; Ryan Emerson; Sharon Benzeno; Marissa Vignali; Xifeng Wu; Yuanqing Ye; Latasha D Little; Curtis Gumbs; Xizeng Mao; Xingzhi Song; Samantha Tippen; Rebecca L Thornton; Tina Cascone; Alexandra Snyder; Jennifer A Wargo; Roy Herbst; Stephen Swisher; Humam Kadara; Cesar Moran; Neda Kalhor; Jianhua Zhang; Paul Scheet; Ara A Vaporciyan; Boris Sepesi; Don L Gibbons; Harlan Robins; Patrick Hwu; John V Heymach; Padmanee Sharma; James P Allison; Veera Baladandayuthapani; Jack J Lee; Mark M Davis; Ignacio I Wistuba; P Andrew Futreal; Jianjun Zhang

doi:10.1038/s41467-019-14273-0

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Comprehensive T cell repertoire characterization of non-small cell lung cancer

Journal article

Peer reviewed

Comprehensive T cell repertoire characterization of non-small cell lung cancer

Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou, Rachel M Gittelman, Jun Li, Won-Chul Lee, Junya Fujimoto, Carmen Behrens, Xiaoke Liu, Feng Wang, …

Nature communications, Vol.11(1), pp.603-603

01/30/2020

DOI: https://doi.org/10.1038/s41467-019-14273-0

PMCID: PMC6992630

PMID: 32001676

Abstract

Adult

Aged

Carcinoma, Non-Small-Cell Lung - immunology

Carcinoma, Non-Small-Cell Lung - pathology

Clone Cells

ErbB Receptors - genetics

ErbB Receptors - metabolism

Female

Humans

Lung - pathology

Lung Neoplasms - immunology

Lung Neoplasms - pathology

Lymphocyte Activation - immunology

Lymphocyte Count

Male

Middle Aged

Mutation - genetics

Survival Analysis

T-Lymphocytes - immunology

Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T cell repertoire attributes are associated with clinicopathologic features, mutational and immune landscape. A considerable proportion of the most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and appear specific to shared background mutations or viral infections. Patients with higher T cell repertoire homology between the tumor and uninvolved tumor-adjacent lung, suggesting a less tumor-focused T cell response, exhibit inferior survival. These findings indicate that a concise understanding of antigens and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunotherapy, particularly adoptive T cell therapy.

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Title: Comprehensive T cell repertoire characterization of non-small cell lung cancer
Creators: Alexandre Reuben - The University of Texas MD Anderson Cancer Center
Jiexin Zhang - The University of Texas MD Anderson Cancer Center
Shin-Heng Chiou - Howard Hughes Medical Institute
Rachel M Gittelman - Adaptive Biotechnologies
Jun Li - The University of Texas MD Anderson Cancer Center
Won-Chul Lee - The University of Texas MD Anderson Cancer Center
Junya Fujimoto - The University of Texas MD Anderson Cancer Center
Carmen Behrens - The University of Texas MD Anderson Cancer Center
Xiaoke Liu - The University of Texas MD Anderson Cancer Center
Feng Wang - The University of Texas MD Anderson Cancer Center
Kelly Quek - The University of Texas MD Anderson Cancer Center
Chunlin Wang - iRepertoire
Farrah Kheradmand - Baylor College of Medicine
Runzhe Chen - The University of Texas MD Anderson Cancer Center
Chi-Wan Chow - The University of Texas MD Anderson Cancer Center
Heather Lin - The University of Texas MD Anderson Cancer Center
Chantale Bernatchez - The University of Texas MD Anderson Cancer Center
Ali Jalali - The University of Texas MD Anderson Cancer Center
Xin Hu - The University of Texas MD Anderson Cancer Center
Chang-Jiun Wu - The University of Texas MD Anderson Cancer Center
Agda Karina Eterovic - The University of Texas MD Anderson Cancer Center
Edwin Roger Parra - The University of Texas MD Anderson Cancer Center
Erik Yusko - Adaptive Biotechnologies
Ryan Emerson - Adaptive Biotechnologies
Sharon Benzeno - Adaptive Biotechnologies
Marissa Vignali - Adaptive Biotechnologies
Xifeng Wu - The University of Texas MD Anderson Cancer Center
Yuanqing Ye - The University of Texas MD Anderson Cancer Center
Latasha D Little - The University of Texas MD Anderson Cancer Center
Curtis Gumbs - The University of Texas MD Anderson Cancer Center
Xizeng Mao - The University of Texas MD Anderson Cancer Center
Xingzhi Song - The University of Texas MD Anderson Cancer Center
Samantha Tippen - The University of Texas MD Anderson Cancer Center
Rebecca L Thornton - The University of Texas MD Anderson Cancer Center
Tina Cascone - The University of Texas MD Anderson Cancer Center
Alexandra Snyder - Adaptive Biotechnologies
Jennifer A Wargo - The University of Texas MD Anderson Cancer Center
Roy Herbst - Yale Cancer Center
Stephen Swisher - The University of Texas MD Anderson Cancer Center
Humam Kadara - The University of Texas MD Anderson Cancer Center
Cesar Moran - The University of Texas MD Anderson Cancer Center
Neda Kalhor - The University of Texas MD Anderson Cancer Center
Jianhua Zhang - The University of Texas MD Anderson Cancer Center
Paul Scheet - The University of Texas MD Anderson Cancer Center
Ara A Vaporciyan - The University of Texas MD Anderson Cancer Center
Boris Sepesi - The University of Texas MD Anderson Cancer Center
Don L Gibbons - The University of Texas MD Anderson Cancer Center
Harlan Robins - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
Patrick Hwu - The University of Texas MD Anderson Cancer Center
John V Heymach - The University of Texas MD Anderson Cancer Center
Padmanee Sharma - The University of Texas MD Anderson Cancer Center
James P Allison - The University of Texas MD Anderson Cancer Center
Veera Baladandayuthapani - The University of Texas MD Anderson Cancer Center
Jack J Lee - The University of Texas MD Anderson Cancer Center
Mark M Davis - Howard Hughes Medical Institute
Ignacio I Wistuba - The University of Texas MD Anderson Cancer Center
P Andrew Futreal - The University of Texas MD Anderson Cancer Center
Jianjun Zhang - The University of Texas MD Anderson Cancer Center
Publication Details: Nature communications, Vol.11(1), pp.603-603
Date published: 01/30/2020
Grant note: UL1 TR001863 / NCATS NIH HHS P30 CA016672 / NCI NIH HHS P50 CA070907 / NCI NIH HHS R01 CA234629 / NCI NIH HHS
Academic Unit: Office of CAOO
Language: English
Resource Type: Journal article
Identifiers: 991031758048804646