Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity

Jan HEERES; Marc R DE JONGE; Frans COMPERNOLLE; Marek CEGLA; Rasha A AZZAM; Koen ANDRIES; Marie-Pierre DE BETHUNE; Hilde AZIJN; Rudi PAUWELS; Paul J LEWI; Paul A. J JANSSEN; Lucien M. H KOYMANS; Frits F. D DAEYAERT; Maarten VINKERS; Koen J. A VAN AKEN; Eddy ARNOLD; Kalyan DAS; Amuri KILONDA; Georges J HOORNAERT

doi:10.1021/jm040829e

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Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity

Journal article

Peer reviewed

Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity

Jan HEERES, Marc R DE JONGE, Frans COMPERNOLLE, Marek CEGLA, Rasha A AZZAM, Koen ANDRIES, Marie-Pierre DE BETHUNE, Hilde AZIJN, Rudi PAUWELS, Paul J LEWI, …

Journal of medicinal chemistry, Vol.48(6), pp.1910-1918

2005

DOI: https://doi.org/10.1021/jm040829e

PMID: 15771435

Abstract

Antiviral agents

Biological and medical sciences

Medical sciences

Pharmacology. Drug treatments

Antibiotics. Antiinfectious agents. Antiparasitic agents

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Title: Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity
Creators: Jan HEERES - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Marc R DE JONGE - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Frans COMPERNOLLE - Center for Molecular Design, Janssen Pharmaceutica, Antwerpsesteenweg 37, 2350 Vosselaar, Belgium
Marek CEGLA - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Rasha A AZZAM - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Koen ANDRIES - J&JPRD, Department of Virology, Janssen Pharmaceutica, Turnhoutseweg 30, 2340 Beerse, Belgium
Marie-Pierre DE BETHUNE - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Hilde AZIJN - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Rudi PAUWELS - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Paul J LEWI - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Paul A. J JANSSEN - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Lucien M. H KOYMANS - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Frits F. D DAEYAERT - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Maarten VINKERS - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Koen J. A VAN AKEN - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Eddy ARNOLD - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Kalyan DAS - Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, United States
Amuri KILONDA - Center for Molecular Design, Janssen Pharmaceutica, Antwerpsesteenweg 37, 2350 Vosselaar, Belgium
Georges J HOORNAERT - Center for Molecular Design, Janssen Pharmaceutica, Antwerpsesteenweg 37, 2350 Vosselaar, Belgium
Publication Details: Journal of medicinal chemistry, Vol.48(6), pp.1910-1918
Date published: 2005
Publisher: American Chemical Society
Academic Unit: Center for Advanced Biotechnology and Medicine
Language: English
Resource Type: Journal article
Identifiers: 991031654012204646