Abstract
This noninferiority randomized trial compares the efficacy and safety of meropenem-vaborbactam vs piperacillin-tazobactam for treatment of adults with complicated urinary tract infection.
- Title
- Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection; The TANGO I Randomized Clinical Trial
- Creators
- Keith S Kaye - Department of Internal Medicine, University of Michigan Medical School, Ann ArborTanaya Bhowmick - Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New JerseySymeon Metallidis - Department of First Internal Medicine, AHEPA Hospital, Medical School, Aristotle University, Thessaloniki, GreeceSusan C Bleasdale - Department of Medicine, University of Illinois College of Medicine, ChicagoOlexiy S Sagan - Department of Urology, Regional Clinical Hospital of Zaporizhizhia, Zaporizhizhia, UkraineViktor Stus - Department of Urology, Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine, DniproJose Vazquez - Division of Infectious Diseases, Medical College of Georgia, Augusta University, AugustaValerii Zaitsev - Clinical Studies Department, Bucovinian State Medical University, Chernivtsi, UkraineMohamed Bidair - San Diego Clinical Trials, San Diego, CaliforniaErik Chorvat - Department of Urology, Urologicke Oddelenie NSP, Poprad, Slovak RepublicPetru Octavian Dragoescu - Department of Urology, Craiova Emergency Clinical Hospital, Craiova, Dolj, RomaniaElena Fedosiuk - Department of Anesthesiology and Intensive Care, Nephrology and Hemocorrection, Brest Regional Hospital, Brest, State Republic of BelarusJuan P Horcajada - Hospital del Mar, Infectious Pathology and Antimicrobials Resaearch Group (IPAR)—Institut Hospital del Mar d’Investigaciones Mèdiques (IMIM), Barcelona, SpainClaudia Murta - Department of Infection Control Service, Santa Casa de Belo Horizonte, Belo Horizonte, Minas Gerais, BrazilYaroslav Sarychev - Department of Urology with Forensic Medicine, Ukrainian Medical Stomatological Academy, Poltava, UkraineVentsislav Stoev - Department of Urology, Mhat Silistra, Silistra, BulgariaElizabeth Morgan - The Medicines Company, San Diego, CaliforniaKaren Fusaro - Melinta Therapeutics, Parsippany, New JerseyDavid Griffith - The Medicines Company, San Diego, CaliforniaOlga Lomovskaya - The Medicines Company, San Diego, CaliforniaElizabeth L Alexander - The Medicines Company, Parsippany, New JerseyJeffery Loutit - The Medicines Company, San Diego, CaliforniaMichael N Dudley - The Medicines Company, San Diego, CaliforniaEvangelos J Giamarellos-Bourboulis - Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Greece
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.319(8), pp.788-799
- Date published
- 02/27/2018
- Publisher
- American Medical Association
- Grant note
- The Medicines Company HHSO100201400002C; HHSO100201600026C / Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority (BARDA)
- Academic Unit
- Medicine - Cardiovascular Diseases and Hypertension (RWJMS); Medicine - Allergy, Immunology, and Infectious Diseases (RWJMS)
- Language
- English
- Resource Type
- Journal article
- Identifiers
- 991031665314204646