Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase

Journal article

Peer reviewed

E Ercikan, M Waltham, A Dicker, B Schweitzer and J R Bertino

Advances in experimental medicine and biology, Vol.338, pp.515-519

1993

PMID: 8304170

Abstract

Amino Acid Sequence

Aminopterin - metabolism

Aminopterin - pharmacology

Codon

Folic Acid Antagonists - metabolism

Folic Acid Antagonists - pharmacology

Humans

Hydrogen-Ion Concentration

Kinetics

Leucine

Methotrexate - metabolism

Methotrexate - pharmacology

Mutagenesis, Site-Directed

Polymerase Chain Reaction - methods

Pyrimidines - metabolism

Pyrimidines - pharmacology

Recombinant Proteins - antagonists & inhibitors

Recombinant Proteins - chemistry

Recombinant Proteins - metabolism

Tetrahydrofolate Dehydrogenase - chemistry

Tetrahydrofolate Dehydrogenase - metabolism

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Title: Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase
Creators: E Ercikan - Program of Molecular Pharmacology, Memorial Sloan-kettering Cancer Center, New York, NY 10021
M Waltham
A Dicker
B Schweitzer
J R Bertino
Publication Details: Advances in experimental medicine and biology, Vol.338, pp.515-519
Date published: 1993
Academic Unit: Bertino Office
Language: English
Resource Type: Journal article
Identifiers: 991031665040904646