Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

Jerimy C Polf; Lawrence F Bronk; Wouter H. P Driessen; Wadih Arap; Renata Pasqualini; Michael Gillin

doi:10.1063/1.3589914

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Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

Journal article

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Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles

Jerimy C Polf, Lawrence F Bronk, Wouter H. P Driessen, Wadih Arap, Renata Pasqualini and Michael Gillin

Applied physics letters, Vol.98(19), pp.193702-193702-3

05/09/2011

DOI: https://doi.org/10.1063/1.3589914

PMCID: PMC3170386

PMID: 21915155

Abstract

Biophysics and Bio-Inspired Systems

The development and use of sensitizing agents to improve the effectiveness of radiotherapy have long been sought to improve our ability to treat cancer. In this letter, we have studied the relative biological effectiveness of proton beam radiotherapy on prostate tumor cells with and without internalized gold nanoparticles. The effectiveness of proton radiotherapy for the killing of prostate tumor cells was increased by approximately 15%–20% for those cells containing internalized gold nanoparticles.

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Title: Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles
Creators: Jerimy C Polf - Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Lawrence F Bronk - Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Wouter H. P Driessen - David H. Koch Center, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Wadih Arap - David H. Koch Center, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Renata Pasqualini - David H. Koch Center, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Michael Gillin - Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Publication Details: Applied physics letters, Vol.98(19), pp.193702-193702-3
Date published: 05/09/2011
Publisher: American Institute of Physics
Academic Unit: Cancer Institute of New Jersey at University Hospital; Radiation Oncology
Language: English
Resource Type: Journal article
Identifiers: 991031653991404646