Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

Ernest K Amankwah; Hui-Yi Lin; Jonathan P Tyrer; Kate Lawrenson; Joe Dennis; Ganna Chornokur; Katja K H Aben; Hoda Anton-Culver; Natalia Antonenkova; Fiona Bruinsma; Elisa V Bandera; Yukie T Bean; Matthias W Beckmann; Maria Bisogna; Line Bjorge; Natalia Bogdanova; Louise A Brinton; Angela Brooks-Wilson; Clareann H Bunker; Ralf Butzow; Ian G Campbell; Karen Carty; Zhihua Chen; Y Ann Chen; Jenny Chang-Claude; Linda S Cook; Daniel W Cramer; Julie M Cunningham; Cezary Cybulski; Agnieszka Dansonka-Mieszkowska; Andreas du Bois; Evelyn Despierre; Ed Dicks; Jennifer A Doherty; Thilo Dörk; Matthias Dürst; Douglas F Easton; Diana M Eccles; Robert P Edwards; Arif B Ekici; Peter A Fasching; Brooke L Fridley; Yu-Tang Gao; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind Glasspool; Marc T Goodman; Jacek Gronwald; Patricia Harrington; Philipp Harter; Hanis N Hasmad; Alexander Hein; Florian Heitz; Michelle A T Hildebrandt; Peter Hillemanns; Claus K Hogdall; Estrid Hogdall; Satoyo Hosono; Edwin S Iversen; Anna Jakubowska; Allan Jensen; Bu-Tian Ji; Beth Y Karlan; Heather Jim; Melissa Kellar; Lambertus A Kiemeney; Camilla Krakstad; Susanne K Kjaer; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Nhu D Le; Alice W Lee; Shashi Lele; Arto Leminen; Jenny Lester; Douglas A Levine; Dong Liang; Boon Kiong Lim; Jolanta Lissowska; Karen Lu; Jan Lubinski; Lene Lundvall; Leon F A G Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Ian McNeish; Usha Menon; Roger L Milne; Francesmary Modugno; Kirsten B Moysich; Roberta B Ness; Heli Nevanlinna; Ursula Eilber; Kunle Odunsi; Sara H Olson; Irene Orlow; Sandra Orsulic; Rachel Palmieri Weber; James Paul; Celeste L Pearce; Tanja Pejovic; Liisa M Pelttari; Jennifer Permuth-Wey; Malcolm C Pike; Elizabeth M Poole; Harvey A Risch; Barry Rosen; Mary Anne Rossing; Joseph H Rothstein; Anja Rudolph; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Eva Schernhammer; Ira Schwaab; Xiao-Ou Shu; Yurii B Shvetsov; Nadeem Siddiqui; Weiva Sieh; Honglin Song; Melissa C Southey; Beata Spiewankiewicz; Lara Sucheston-Campbell; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Lotte Thomsen; Ingvild L Tangen; Shelley S Tworoger; Anne M van Altena; Robert A Vierkant; Ignace Vergote; Christine S Walsh; Shan Wang-Gohrke; Nicolas Wentzensen; Alice S Whittemore; Kristine G Wicklund; Lynne R Wilkens; Anna H Wu; Xifeng Wu; Yin-Ling Woo; Hannah Yang; Wei Zheng; Argyrios Ziogas; Linda E Kelemen; Andrew Berchuck; Joellen M Schildkraut; Susan J Ramus; Ellen L Goode; Alvaro N A Monteiro; Simon A Gayther; Steven A Narod; Paul D P Pharoah; Thomas A Sellers; Catherine M Phelan; Georgia Chenevix-Trench on behalf of the AOCS management group

doi:10.1002/gepi.21921

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Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

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Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

Ernest K Amankwah, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ganna Chornokur, Katja K H Aben, Hoda Anton-Culver, Natalia Antonenkova, Fiona Bruinsma, …

Genetic epidemiology, Vol.39(8), pp.689-697

12/2015

DOI: https://doi.org/10.1002/gepi.21921

PMID: 26399219

Abstract

Adult

Aged

Carcinoma, Ovarian Epithelial

Epithelial-Mesenchymal Transition - genetics

European Continental Ancestry Group

Female

Genetic Predisposition to Disease

Genome-Wide Association Study

Genotype

Humans

Middle Aged

Neoplasms, Glandular and Epithelial - epidemiology

Neoplasms, Glandular and Epithelial - genetics

Odds Ratio

Ovarian Neoplasms - epidemiology

Ovarian Neoplasms - genetics

Polymorphism, Single Nucleotide - genetics

Risk

Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value <0.05 and a false discovery rate (FDR) <0.2 were considered statistically significant. In the larger dataset, GPC6/GPC5 rs17702471 was associated with the endometrioid subtype among Caucasians (odds ratio (OR) = 1.16, 95% CI = 1.07-1.25, P = 0.0003, FDR = 0.19), whereas F8 rs7053448 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), F8 rs7058826 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), and CAPN13 rs1983383 (OR = 0.79, 95% CI = 0.69-0.90, P = 0.0005, FDR = 0.12) were associated with combined invasive EOC among Asians. In silico functional analyses revealed that GPC6/GPC5 rs17702471 coincided with DNA regulatory elements. These results suggest that EMT gene variants do not appear to play a significant role in the susceptibility to EOC.

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Title: Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk
Creators: Ernest K Amankwah - Clinical and Translational Research Organization, All Children's Hospital Johns Hopkins Medicine, St. Petersburg, Florida, United States of America
Hui-Yi Lin - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Jonathan P Tyrer - Centre for Cancer Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Kate Lawrenson - Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Joe Dennis - Centre for Cancer Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Ganna Chornokur - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Katja K H Aben - Comprehensive Cancer Center The Netherlands, Nijmegen, The Netherlands
Hoda Anton-Culver - Genetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, United States of America
Natalia Antonenkova - Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N, Minsk, Belarus
Fiona Bruinsma - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
Elisa V Bandera - Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
Yukie T Bean - Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America
Matthias W Beckmann - Erlangen-Nuremberg Comprehensive Cancer Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen EMN, Germany
Maria Bisogna - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Line Bjorge - Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Natalia Bogdanova - Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Angela Brooks-Wilson - Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
Clareann H Bunker - Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
Ralf Butzow - Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
Ian G Campbell - Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia
Karen Carty - CRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Zhihua Chen - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Y Ann Chen - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Jenny Chang-Claude - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Linda S Cook - Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America
Daniel W Cramer - Obstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
Cezary Cybulski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Agnieszka Dansonka-Mieszkowska - Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Andreas du Bois - Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Evelyn Despierre - Division of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium
Ed Dicks - Centre for Cancer Epidemiology, Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Jennifer A Doherty - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washigton, United States of America
Thilo Dörk - Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
Matthias Dürst - Department of Gynecology, Friedrich Schiller University, Jena, Germany
Douglas F Easton - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Diana M Eccles - Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom
Robert P Edwards - Ovarian Cancer Center of Excellence, Department of Obstetrics Gynecology/RS, Division of Gynecological Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Arif B Ekici - Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Peter A Fasching - Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
Brooke L Fridley - Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, United States of America
Yu-Tang Gao - Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Aleksandra Gentry-Maharaj - Women's Cancer, UCL EGA Institute for Women's Health, London, United Kingdom
Graham G Giles - Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia
Rosalind Glasspool - CRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Marc T Goodman - Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Jacek Gronwald - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Patricia Harrington - Centre for Cancer Epidemiology, Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Philipp Harter - Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Hanis N Hasmad - Cancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia
Alexander Hein - Erlangen-Nuremberg Comprehensive Cancer Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen EMN, Germany
Florian Heitz - Department of Gynaecology and Gynaecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Michelle A T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Peter Hillemanns - Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
Claus K Hogdall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Estrid Hogdall - Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Edwin S Iversen - Department of Statistics, Duke University, Durham, North Carolina, United States of America
Anna Jakubowska - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Allan Jensen - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Bu-Tian Ji - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Heather Jim - Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Forida, United States of America
Melissa Kellar - Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America
Lambertus A Kiemeney - Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Camilla Krakstad - Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Susanne K Kjaer - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Jolanta Kupryjanczyk - Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Diether Lambrechts - Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium
Sandrina Lambrechts - Division of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium
Nhu D Le - Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada
Alice W Lee - Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Shashi Lele - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Arto Leminen - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, HUS, Finland
Jenny Lester - Women's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Douglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, United States of America
Boon Kiong Lim - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Karen Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Jan Lubinski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Lene Lundvall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Leon F A G Massuger - Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands
Keitaro Matsuo - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Valerie McGuire - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
John R McLaughlin - Public Health Ontario, Toronto, Ontario, Canada
Ian McNeish - CRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Usha Menon - Women's Cancer, UCL EGA Institute for Women's Health, London, United Kingdom
Roger L Milne - Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia
Francesmary Modugno - Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Roberta B Ness - School of Public Health, The University of Texas, Houston, Texas, United States of America
Heli Nevanlinna - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, HUS, Finland
Ursula Eilber - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Kunle Odunsi - Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Irene Orlow - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Sandra Orsulic - Women's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Rachel Palmieri Weber - Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
James Paul - CRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Celeste L Pearce - Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America
Tanja Pejovic - Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America
Liisa M Pelttari - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, HUS, Finland
Jennifer Permuth-Wey - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Malcolm C Pike - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, United States of America
Elizabeth M Poole - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America
Barry Rosen - Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washigton, United States of America
Joseph H Rothstein - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
Anja Rudolph - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Ingo B Runnebaum - Department of Gynecology, Friedrich Schiller University, Jena, Germany
Iwona K Rzepecka - Department of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Helga B Salvesen - Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Eva Schernhammer - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Ira Schwaab - Institut für Humangenetik, Wiesbaden, Germany
Xiao-Ou Shu - Epidemiology Center and Vanderbilt, Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennesse, United States of America
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America
Nadeem Siddiqui - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom
Weiva Sieh - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
Honglin Song - Centre for Cancer Epidemiology, Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Melissa C Southey - Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
Beata Spiewankiewicz - Department of Gynecologic Oncology, Institute of Oncology, Warsaw, Poland
Lara Sucheston-Campbell - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Soo-Hwang Teo - University Malaya Medical Centre, University of Malaya, Kuala Lumpur, Maylaysia
Kathryn L Terry - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Pamela J Thompson - Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Lotte Thomsen - Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Ingvild L Tangen - Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Shelley S Tworoger - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Anne M van Altena - Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands
Robert A Vierkant - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
Ignace Vergote - Division of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium
Christine S Walsh - Women's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
Shan Wang-Gohrke - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Alice S Whittemore - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America
Kristine G Wicklund - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washigton, United States of America
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America
Anna H Wu - Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Yin-Ling Woo - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Hannah Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
Wei Zheng - Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennesse, United States of America
Argyrios Ziogas - Genetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, United States of America
Linda E Kelemen - Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, United States of America
Joellen M Schildkraut - Cancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, United States of America
Susan J Ramus - Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Ellen L Goode - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, United States of America
Alvaro N A Monteiro - Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America
Simon A Gayther - Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Steven A Narod - Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada
Paul D P Pharoah - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Thomas A Sellers - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Catherine M Phelan - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America
Georgia Chenevix-Trench on behalf of the AOCS management group
Publication Details: Genetic epidemiology, Vol.39(8), pp.689-697
Date published: 12/2015
Grant note: R03 CA113148 / NCI NIH HHS N01 CN025403 / NCI NIH HHS R01 CA-1491429 / NCI NIH HHS T32ES013678 / NIEHS NIH HHS K22 CA138563 / NCI NIH HHS R25T CA147832 / NCI NIH HHS R03 CA115195 / NCI NIH HHS U01 CA049449 / NCI NIH HHS P30 CA071789 / NCI NIH HHS U01 CA069417 / NCI NIH HHS R01 CA063682 / NCI NIH HHS R01 CA058598 / NCI NIH HHS P01 CA017054 / NCI NIH HHS C490/A10124 / Cancer Research UK R01 CA067262 / NCI NIH HHS R01 CA080742 / NCI NIH HHS P50 CA105009 / NCI NIH HHS R01 CA083918 / NCI NIH HHS U01 CA058860 / NCI NIH HHS R01 CA074850 / NCI NIH HHS R01 CA054419 / NCI NIH HHS R01 CA076016 / NCI NIH HHS R01 CA136924 / NCI NIH HHS K07 CA092044 / NCI NIH HHS P01 CA087969 / NCI NIH HHS K07 CA143047 / NCI NIH HHS P30 CA016056 / NCI NIH HHS MOP-86727 / CIHR R01 CA087538 / NCI NIH HHS R01 CA122443 / NCI NIH HHS N01 PC035137 / NCI NIH HHS UM1 CA182910 / NCI NIH HHS T32 ES013678 / NIEHS NIH HHS R01 CA058860 / NCI NIH HHS 1K99CA184415-01 / NCI NIH HHS C490/A10119 / Cancer Research UK R01 CA063678 / NCI NIH HHS U01 CA067262 / NCI NIH HHS P30 CA015083 / NCI NIH HHS K07 CA095666 / NCI NIH HHS R01 CA112523 / NCI NIH HHS R01 CA149429 / NCI NIH HHS R01 CA114343 / NCI NIH HHS K99 CA184415 / NCI NIH HHS R01 CA087696 / NCI NIH HHS 10124 / Cancer Research UK U19 CA148112 / NCI NIH HHS C490/A6187 / Cancer Research UK P30 CA076292 / NCI NIH HHS R25 CA147832 / NCI NIH HHS N01 PC067010 / NCI NIH HHS R01-CA076016 / NCI NIH HHS R01 CA050385 / NCI NIH HHS P30 CA008748 / NCI NIH HHS P50 CA136393 / NCI NIH HHS R01 CA049449 / NCI NIH HHS R01 CA126841 / NCI NIH HHS P30 CA014089 / NCI NIH HHS P30 CA072720 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665082804646