GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

Paul D. P Pharoah; Ya-Yu Tsai; Susan J Ramus; Catherine M Phelan; Ellen L Goode; Kate Lawrenson; Melissa Price; Brooke L Fridley; Jonathan P Tyrer; Howard Shen; Rachel Weber; Rod Karevan; Melissa C Larson; Honglin Song; Daniel C Tessier; François Bacot; Daniel Vincent; Julie M Cunningham; Joe Dennis; Ed Dicks; Katja K Aben; Hoda Anton-Culver; Natalia Antonenkova; Sebastian M Armasu; Laura Baglietto; Elisa V Bandera; Matthias W Beckmann; Michael J Birrer; Greg Bloom; Natalia Bogdanova; James D Brenton; Louise A Brinton; Angela Brooks-Wilson; Robert Brown; Ralf Butzow; Ian Campbell; Michael E Carney; Renato S Carvalho; Jenny Chang-Claude; Y. Anne Chen; Zhihua Chen; Wong-Ho Chow; Mine S Cicek; Gerhard Coetzee; Linda S Cook; Daniel W Cramer; Cezary Cybulski; Agnieszka Dansonka-Mieszkowska; Evelyn Despierre; Jennifer A Doherty; Thilo Dörk; Andreas du Bois; Matthias Dürst; Diana Eccles; Robert Edwards; Arif B Ekici; Peter A Fasching; David Fenstermacher; James Flanagan; Yu-Tang Gao; Montserrat Garcia-Closas; Aleksandra Gentry-Maharaj; Graham Giles; Anxhela Gjyshi; Martin Gore; Jacek Gronwald; Qi Guo; Mari K Halle; Philipp Harter; Alexander Hein; Florian Heitz; Peter Hillemanns; Maureen Hoatlin; Estrid Høgdall; Claus K Høgdall; Satoyo Hosono; Anna Jakubowska; Allan Jensen; Kimberly R Kalli; Beth Y Karlan; Linda E Kelemen; Lambertus A Kiemeney; Susanne Krüger Kjaer; Gottfried E Konecny; Camilla Krakstad; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Nhu D Le; Nathan Lee; Janet Lee; Arto Leminen; Boon Kiong Lim; Jolanta Lissowska; Jan Lubiński; Lene Lundvall; Galina Lurie; Leon F.A.G Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Usha Menon; Francesmary Modugno; Kirsten B Moysich; Toru Nakanishi; Steven A Narod; Roberta B Ness; Heli Nevanlinna; Stefan Nickels; Houtan Noushmehr; Kunle Odunsi; Sara Olson; Irene Orlow; James Paul; Tanja Pejovic; Liisa M Pelttari; Jenny Permuth-Wey; Malcolm C Pike; Elizabeth M Poole; Xiaotao Qu; Harvey A Risch; Lorna Rodriguez-Rodriguez; Mary Anne Rossing; Anja Rudolph; Ingo Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Ira Schwaab; Gianluca Severi; Hui Shen; Vijayalakshmi Shridhar; Xiao-Ou Shu; Weiva Sieh; Melissa C Southey; Paul Spellman; Kazuo Tajima; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Agnieszka Timorek; Shelley S Tworoger; Anne M van Altena; David Van Den Berg; Ignace Vergote; Robert A Vierkant; Allison F Vitonis; Shan Wang-Gohrke; Nicolas Wentzensen; Alice S Whittemore; Elisabeth Wik; Boris Winterhoff; Yin Ling Woo; Anna H Wu; Hannah P Yang; Wei Zheng; Argyrios Ziogas; Famida Zulkifli; Marc T Goodman; Per Hall; Douglas F Easton; Celeste L Pearce; Andrew Berchuck; Georgia Chenevix-Trench; Edwin Iversen; Alvaro N.A Monteiro; Simon A Gayther; Australian Ovarian Canc Study Grp; Joellen M Schildkraut; Thomas A Sellers

doi:10.1038/ng.2564

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GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

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GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

Paul D. P Pharoah, Ya-Yu Tsai, Susan J Ramus, Catherine M Phelan, Ellen L Goode, Kate Lawrenson, Melissa Price, Brooke L Fridley, Jonathan P Tyrer, Howard Shen, …

Nature genetics, Vol.45(4), pp.362-370e2

04/2013

DOI: https://doi.org/10.1038/ng.2564

PMCID: PMC3693183

PMID: 23535730

Abstract

Genome wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC) with another two loci being close to genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the United Kingdom. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. Follow-up genotyping was carried out in 18,174 cases and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 previously near genome-wide significance and identified three novel loci associated with risk; two loci associated with all EOC subtypes, at 8q21 (rs11782652, P=5.5×10 -9 ) and 10p12 (rs1243180; P=1.8×10 -8 ), and another locus specific to the serous subtype at 17q12 (rs757210; P=8.1×10 -10 ). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility that implicates CHMP4C in the pathogenesis of ovarian cancer.

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Title: GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
Creators: Paul D. P Pharoah - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Ya-Yu Tsai - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Susan J Ramus - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Catherine M Phelan - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Ellen L Goode - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
Kate Lawrenson - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Melissa Price - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Brooke L Fridley - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
Jonathan P Tyrer - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Howard Shen - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Rachel Weber - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
Rod Karevan - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Melissa C Larson - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA
Honglin Song - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Daniel C Tessier - McGill University, Montreal, Canada
François Bacot - McGill University, Montreal, Canada
Daniel Vincent - McGill University, Montreal, Canada
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA
Joe Dennis - The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Ed Dicks - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Katja K Aben - Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, Netherlands
Hoda Anton-Culver - Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California Irvine, Irvine, California, USA
Natalia Antonenkova - Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus
Sebastian M Armasu - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA
Laura Baglietto - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Elisa V Bandera - The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Matthias W Beckmann - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany
Michael J Birrer - Harvard Medical School, Boston, Massachusetts, United States of America
Greg Bloom - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Natalia Bogdanova - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
James D Brenton - Cambridge Research Institute Li Ka Shing Centre, Cambridge, UK
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA
Angela Brooks-Wilson - Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada
Robert Brown - Department of Surgery and Cancer, Imperial College London, London, UK
Ralf Butzow - Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
Ian Campbell - Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia
Michael E Carney - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA
Renato S Carvalho - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Jenny Chang-Claude - German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany
Y. Anne Chen - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Zhihua Chen - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Wong-Ho Chow - Division of Cancer Etiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Mine S Cicek - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
Gerhard Coetzee - Department of Microbiology and Preventive Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA
Linda S Cook - Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA
Daniel W Cramer - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cezary Cybulski - International Hereditary Cancer Center, Department of Genetics and Pathology. Pomeranian Medical University, Szczecin, Poland
Agnieszka Dansonka-Mieszkowska - Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Evelyn Despierre - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, Leuven Cancer Institute, Leuven, Belgium
Jennifer A Doherty - Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Thilo Dörk - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
Andreas du Bois - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Matthias Dürst - Department of Gynecology, Jena University Hospital, Jena, Germany
Diana Eccles - Faculty of Medicine, University of Southampton, University Hospital Southampton, UK
Robert Edwards - Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA
Arif B Ekici - Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Peter A Fasching - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany
David Fenstermacher - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
James Flanagan - Department of Surgery and Cancer, Imperial College London, London, UK
Yu-Tang Gao - Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Montserrat Garcia-Closas - Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Aleksandra Gentry-Maharaj - Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, London, United Kingdom
Graham Giles - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Anxhela Gjyshi - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Martin Gore - Gynecological Oncology Unit, The Royal Marsden Hospital, United Kingdom
Jacek Gronwald - International Hereditary Cancer Center, Department of Genetics and Pathology. Pomeranian Medical University, Szczecin, Poland
Qi Guo - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Mari K Halle - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
Philipp Harter - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Alexander Hein - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany
Florian Heitz - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Peter Hillemanns - Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
Maureen Hoatlin - Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, USA
Estrid Høgdall - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Claus K Høgdall - The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Anna Jakubowska - International Hereditary Cancer Center, Department of Genetics and Pathology. Pomeranian Medical University, Szczecin, Poland
Allan Jensen - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Kimberly R Kalli - Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California
Linda E Kelemen - Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, Alberta, Canada
Lambertus A Kiemeney - Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, Netherlands
Susanne Krüger Kjaer - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Gottfried E Konecny - Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, USA
Camilla Krakstad - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
Jolanta Kupryjanczyk - Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Diether Lambrechts - Vesalius Research Center, University of Leuven, Belgium
Sandrina Lambrechts - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, Leuven Cancer Institute, Leuven, Belgium
Nhu D Le - Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada
Nathan Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Janet Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Arto Leminen - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Boon Kiong Lim - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Jolanta Lissowska - The Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland
Jan Lubiński - International Hereditary Cancer Center, Department of Genetics and Pathology. Pomeranian Medical University, Szczecin, Poland
Lene Lundvall - The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark
Galina Lurie - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA
Leon F.A.G Massuger - Department of Gynaecology, Radboud University Medical Centre, Nijmegen, Netherlands
Keitaro Matsuo - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Valerie McGuire - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA
John R McLaughlin - Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Canada
Usha Menon - Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, London, United Kingdom
Francesmary Modugno - Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
Toru Nakanishi - Department of Gynecologic Oncology, Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan
Steven A Narod - Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada
Roberta B Ness - The University of Texas School of Public Health, Houston, TX, USA
Heli Nevanlinna - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Stefan Nickels - German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany
Houtan Noushmehr - Department of Microbiology and Preventive Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA
Kunle Odunsi - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
Sara Olson - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Irene Orlow - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
James Paul - The Beatson West of Scotland Cancer Centre, Glasgow, UK
Tanja Pejovic - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, USA
Liisa M Pelttari - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
Jenny Permuth-Wey - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Malcolm C Pike - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Elizabeth M Poole - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Xiaotao Qu - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Harvey A Risch - Department of Epidemiology and Public Health, Yale University School of Public Health and School of Medicine
Lorna Rodriguez-Rodriguez - The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Mary Anne Rossing - Department of Epidemiology, University of Washington, Seattle, WA, USA
Anja Rudolph - German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany
Ingo Runnebaum - Department of Gynecology, Jena University Hospital, Jena, Germany
Iwona K Rzepecka - Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Helga B Salvesen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
Ira Schwaab - Institut für Humangenetik Wiesbaden, Wiesbaden, Germany
Gianluca Severi - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Hui Shen - USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA
Vijayalakshmi Shridhar - Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA
Xiao-Ou Shu - Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Weiva Sieh - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA
Melissa C Southey - Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
Paul Spellman - Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, USA
Kazuo Tajima - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Soo-Hwang Teo - Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia
Kathryn L Terry - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Pamela J Thompson - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA
Agnieszka Timorek - Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University, Warsaw, Poland
Shelley S Tworoger - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Anne M van Altena - Department of Gynaecology, Radboud University Medical Centre, Nijmegen, Netherlands
David Van Den Berg - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Ignace Vergote - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, Leuven Cancer Institute, Leuven, Belgium
Robert A Vierkant - Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
Allison F Vitonis - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Shan Wang-Gohrke - Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA
Alice S Whittemore - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA
Elisabeth Wik - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
Boris Winterhoff - Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA
Yin Ling Woo - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Hannah P Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA
Wei Zheng - Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Argyrios Ziogas - Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California Irvine, Irvine, California, USA
Famida Zulkifli - Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia
Marc T Goodman - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA
Per Hall - Department of Epidemiology and Biostatistics, Karolinska Istitutet, Stockholm, Sweden
Douglas F Easton - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Celeste L Pearce - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA
Georgia Chenevix-Trench - Cancer Division, Queensland Institute of Medical Research, Herston, QLD, Australia
Edwin Iversen - Department of Statistics, Duke University, Durham, NC, USA
Alvaro N.A Monteiro - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Simon A Gayther - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
Australian Ovarian Canc Study Grp
Joellen M Schildkraut - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
Thomas A Sellers - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA
Publication Details: Nature genetics, Vol.45(4), pp.362-370e2
Date published: 04/2013
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031666382604646