Genome-wide association studies identify four ER negative–specific breast cancer risk loci

Montserrat Garcia-Closas; Fergus J Couch; Sara Lindstrom; Kyriaki Michailidou; Marjanka K Schmidt; Mark N Brook; Nick orr; Suhn Kyong Rhie; Elio Riboli; Heather s Feigelson; Loic Le Marchand; Julie E Buring; Diana Eccles; Penelope Miron; Peter A Fasching; Hiltrud Brauch; Jenny Chang-Claude; Jane Carpenter; Andrew K Godwin; Heli Nevanlinna; Graham G Giles; Angela Cox; John L Hopper; Manjeet K Bolla; Qin Wang; Joe Dennis; Ed Dicks; Will J Howat; Nils Schoof; Stig E Bojesen; Diether Lambrechts; Annegien Broeks; Irene L Andrulis; Pascal Guénel; Barbara Burwinkel; Elinor J Sawyer; Antoinette Hollestelle; Olivia Fletcher; Robert Winqvist; Hermann Brenner; Arto Mannermaa; Ute Hamann; Alfons Meindl; Annika Lindblom; Wei Zheng; Peter Devillee; Mark S Goldberg; Jan Lubinski; Vessela Kristensen; Anthony Swerdlow; Hoda Anton-Culver; Thilo Dörk; Kenneth Muir; Keitaro Matsuo; Anna H Wu; Paolo Radice; Soo Hwang Teo; Xiao-Ou Shu; William Blot; Daehee Kang; Mikael Hartman; Suleeporn Sangrajrang; Chen-Yang Shen; Melissa C Southey; Daniel J Park; Fleur Hammet; Jennifer Stone; Laura J Van’t Veer; Emiel J Rutgers; Artitaya Lophatananon; Sarah Stewart-Brown; Pornthep Siriwanarangsan; Julian Peto; Michael G Schrauder; Arif B Ekici; Matthias W Beckmann; Isabel dos Santos Silva; Nichola Johnson; Helen Warren; Ian Tomlinson; Michael J Kerin; Nicola Miller; Federick Marme; Andreas Schneeweiss; Christof Sohn; Therese Truong; Pierre Laurent-Puig; Pierre Kerbrat; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Roger L Milne; Jose Ignacio Arias Perez; Primitiva Menéndez; Heiko Müller; Volker Arndt; Christa Stegmaier; Peter Lichtner; Magdalena Lochmann; Christina Justenhoven; Yon-Dschun Ko; Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Dario Greco; Tuomas Heikkinen; Hidemi Ito; Hiroji Iwata; Yasushi Yatabe; Natalia N Antonenkova; Sara Margolin; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Rosemary Balleine; Chiu-Chen Tseng; David Van Den Berg; Daniel O Stram; Patrick Neven; Anne-Sophie Dieudonné; Karin Leunen; Anja Rudolph; Stefan Nickels; Dieter Flesch-Janys; Paolo Peterlongo; Bernard Peissel; Loris Bernard; Janet E Olson; Xianshu Wang; Kristen Stevens; Gianluca Severi; Laura Baglietto; Catriona Mclean; Gerhard A Coetzee; Ye Feng; Brian E Henderson; Fredrick Schumacher; Natalia V Bogdanova; France Labrèche; Martine Dumont; Cheng Har Yip; Nur Aishah Mohd Taib; Ching-Yu Cheng; Martha Shrubsole; Jirong Long; Katri Pylkäs; Arja Jukkola-Vuorinen; Saila Kauppila; Julia A knight; Gord Glendon; Anna Marie Mulligan; Robertus A E M Tollenaar; Caroline M Seynaeve; Mieke Kriege; Maartje J Hooning; Ans M W Van den Ouweland; Carolien H M Van Deurzen; Wei Lu; Yu-Tang Gao; Hui Cai; Sabapathy P Balasubramanian; Simon S Cross; Malcolm W R Reed; Lisa Signorello; Qiuyin Cai; Mitul Shah; Hui Miao; Ching Wan Chan; Kee Seng Chia; Anna Jakubowska; Katarzyna Jaworska; Katarzyna Durda; Chia-Ni Hsiung; Pei-Ei Wu; Jyh-Cherng Yu; Alan Ashworth; Michael Jones; Daniel C Tessier; Anna González-Neira; Guillermo Pita; M Rosario Alonso; Daniel Vincent; Francois Bacot; Christine B Ambrosone; Elisa V Bandera; Esther M John; Gary K Chen; Jennifer J Hu; Jorge L Rodriguez-gil; Leslie Bernstein; Michael F Press; Regina G Ziegler; Robert M Millikan; Sandra L Deming-Halverson; Sarah Nyante; Sue A Ingles; Quinten Waisfisz; Helen Tsimiklis; Enes Makalic; Daniel Schmidt; Minh Bui; Lorna Gibson; Bertram Müller-Myhsok; Rita K Schmutzler; Rebecca Hein; Norbert Dahmen; Lars Beckmann; Kirsimari Aaltonen; Kamila Czene; Astrid Irwanto; Jianjun Liu; Clare Turnbull; Nazneen Rahman; Hanne Meijers-Heijboer; Andre G Uitterlinden; Fernando Rivadeneira; Curtis Olswold; Irene Konstantopoulou; Susan Slager; Nicholas G Martin; Robert Pilarski; Grant W Montgomery; Foluso Ademuyiwa; Dennis J Slamon; Claudia Rauh; Michael P Lux; Sebastian M Jud; Thomas Bruning; Joellen Weaver; Priyanka Sharma; Harsh Pathak; Will Tapper; Sue Gerty; Lorraine Durcan; Dimitrios Trichopoulos; Rosario Tumino; Petra H Peeters; Rudolf Kaaks; Daniele Campa; Federico Canzian; Elisabete Weiderpass; Mattias Johansson; Kay-Tee Khaw; Ruth Travis; Françoise Clavel-Chapelon; Laurence N Kolonel; Constance Chen; Andy Beck; Susan E Hankinson; Christine D Berg; Robert N Hoover; Jolanta Lissowska; Jonine D Figueroa; Daniel I Chasman; Mia M Gaudet; W Ryan Diver; Walter C Willett; David J Hunter; Jacques Simard; Javier Benitez; Alison M Dunning; Mark E Sherman; Georgia Chenevix-Trench; Stephen J Chanock; Per Hall; Paul D P Pharoah; KConFab Investigators; Celine Vachon; Douglas F Easton; Christopher A Haiman; Peter Kraft

doi:10.1038/ng.2561

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Genome-wide association studies identify four ER negative–specific breast cancer risk loci

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Genome-wide association studies identify four ER negative–specific breast cancer risk loci

Montserrat Garcia-Closas, Fergus J Couch, Sara Lindstrom, Kyriaki Michailidou, Marjanka K Schmidt, Mark N Brook, Nick orr, Suhn Kyong Rhie, Elio Riboli, Heather s Feigelson, …

Nature genetics, Vol.45(4), pp.392-398e2

04/2013

DOI: https://doi.org/10.1038/ng.2561

PMCID: PMC3771695

PMID: 23535733

Abstract

Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry 1 . The etiology 2 and clinical behavior 3 of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition 4 . To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 ( MDM4 , P = 2.1 × 10 −12 and LGR6 , P = 1.4 × 10 −8 ), 2p24.1 ( P = 4.6 × 10 −8 ) and 16q12.2 ( FTO , P = 4.0 × 10 −8 ), were associated with ER-negative but not ER-positive breast cancer ( P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.

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Title: Genome-wide association studies identify four ER negative–specific breast cancer risk loci
Creators: Montserrat Garcia-Closas - Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Fergus J Couch - Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Sara Lindstrom - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Kyriaki Michailidou - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Marjanka K Schmidt - Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Mark N Brook - Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Nick orr - Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
Suhn Kyong Rhie - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Elio Riboli - School of Public Health, Imperial College, London, UK
Heather s Feigelson - Kaiser Permanente, Institute for Health Research, Denver, Colorado, USA
Loic Le Marchand - Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, USA
Julie E Buring - Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Diana Eccles - Faculty of Medicine, University of Southampton, Southampton, UK
Penelope Miron - Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Peter A Fasching - Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Erlangen, Germany
Hiltrud Brauch - Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
Jenny Chang-Claude - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Jane Carpenter - Australian Breast Cancer Tissue Bank, University of Sydney at the Westmead Millennium Institute, Westmead, New South Wales, Australia
Andrew K Godwin - Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Graham G Giles - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia
Angela Cox - Cancer Research UK/Yorkshire Cancer Research Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK
John L Hopper - Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia
Manjeet K Bolla - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Qin Wang - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Joe Dennis - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Ed Dicks - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Will J Howat - Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
Nils Schoof - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Stig E Bojesen - Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
Diether Lambrechts - Vesalius Research Center (VRC), VIB, Leuven, Belgium
Annegien Broeks - Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Irene L Andrulis - Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Pascal Guénel - University Paris–Sud, Unité Mixte de Recherche Scientifique (UMRS) 1018, Villejuif, France
Barbara Burwinkel - Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
Elinor J Sawyer - Division of Cancer Studies, National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre, Guy’s & St. Thomas’ National Health Service (NHS) Foundation Trust in partnership with King’s College London, London, UK
Antoinette Hollestelle - Department of Medical Oncology, Erasmus University Medical Center–Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands
Olivia Fletcher - Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
Robert Winqvist - Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland
Hermann Brenner - Division of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany
Arto Mannermaa - Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
Ute Hamann - Molecular Genetics of Breast Cancer, DKFZ, Heidelberg, Germany
Alfons Meindl - Division for Gynaecological Tumor Genetics, Clinic of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany
Annika Lindblom - Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Wei Zheng - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Peter Devillee - Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Mark S Goldberg - Department of Medicine, McGill University, Montreal, Quebec, Canada
Jan Lubinski - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Vessela Kristensen - Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
Anthony Swerdlow - Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Hoda Anton-Culver - Department of Epidemiology, University of California–Irvine, Irvine, California, USA
Thilo Dörk - Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
Kenneth Muir - Warwick Medical School, Warwick University, Coventry, UK
Keitaro Matsuo - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Paolo Radice - Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy
Soo Hwang Teo - Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, University Malaya Cancer Research Institute, University Malaya, Kuala Lumpur, Malaysia
Xiao-Ou Shu - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
William Blot - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Daehee Kang - Seoul National University College of Medicine, Seoul, Korea
Mikael Hartman - Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Suleeporn Sangrajrang - National Cancer Institute, Bangkok, Thailand
Chen-Yang Shen - Colleague of Public Health, China Medical University, Taichong, Taiwan
Melissa C Southey - Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
Daniel J Park - Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
Fleur Hammet - Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
Jennifer Stone - Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia
Laura J Van’t Veer - Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Emiel J Rutgers - Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Artitaya Lophatananon - Warwick Medical School, Warwick University, Coventry, UK
Sarah Stewart-Brown - Warwick Medical School, Warwick University, Coventry, UK
Pornthep Siriwanarangsan - Ministry of Public Health, Bangkok, Thailand
Julian Peto - Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
Michael G Schrauder - Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Erlangen, Germany
Arif B Ekici - Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany
Matthias W Beckmann - Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Erlangen, Germany
Isabel dos Santos Silva - Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
Nichola Johnson - Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
Helen Warren - Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
Ian Tomlinson - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Michael J Kerin - Department of Surgery, Clinical Science Institute, University Hospital and National University of Ireland, Galway, Ireland
Nicola Miller - Department of Surgery, Clinical Science Institute, University Hospital and National University of Ireland, Galway, Ireland
Federick Marme - Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
Andreas Schneeweiss - Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
Christof Sohn - Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
Therese Truong - University Paris–Sud, Unité Mixte de Recherche Scientifique (UMRS) 1018, Villejuif, France
Pierre Laurent-Puig - INSERM, Université Paris Sorbonne Cité, UMRS 775, Paris, France
Pierre Kerbrat - Centre Eugène Marquis, Department of Medical Oncology, Rennes, France
Børge G Nordestgaard - Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
Sune F Nielsen - Copenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
Henrik Flyger - Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
Roger L Milne - Genetic & Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Jose Ignacio Arias Perez - Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain
Primitiva Menéndez - Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain
Heiko Müller - Division of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany
Volker Arndt - Division of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany
Christa Stegmaier - Saarland Cancer Registry, Saarbrücken, Germany
Peter Lichtner - Institute of Human Genetics, Technische Universität München, Munich, Germany
Magdalena Lochmann - Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany
Christina Justenhoven - Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
Yon-Dschun Ko - Department of Internal Medicine, Evangelische Kliniken Bonn, Johanniter Krankenhaus, Bonn, Germany
Taru A Muranen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Kristiina Aittomäki - Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland
Carl Blomqvist - Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Dario Greco - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Tuomas Heikkinen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Hidemi Ito - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Hiroji Iwata - Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
Yasushi Yatabe - Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
Natalia N Antonenkova - N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus
Sara Margolin - Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Vesa Kataja - School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio, Finland
Veli-Matti Kosma - Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
Jaana M Hartikainen - Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
Rosemary Balleine - Western Sydney Local Health District, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia
Chiu-Chen Tseng - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
David Van Den Berg - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Daniel O Stram - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Patrick Neven - Multidisciplinary Breast Center, University Hospital Gasthuisberg, Department of Oncology, University of Leuven, Leuven, Belgium
Anne-Sophie Dieudonné - Multidisciplinary Breast Center, University Hospital Gasthuisberg, Department of Oncology, University of Leuven, Leuven, Belgium
Karin Leunen - Multidisciplinary Breast Center, University Hospital Gasthuisberg, Department of Oncology, University of Leuven, Leuven, Belgium
Anja Rudolph - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Stefan Nickels - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Dieter Flesch-Janys - Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany
Paolo Peterlongo - Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy
Bernard Peissel - Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS INT, Milan, Italy
Loris Bernard - Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy
Janet E Olson - Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Xianshu Wang - Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Kristen Stevens - Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Gianluca Severi - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia
Laura Baglietto - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia
Catriona Mclean - Department of Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia
Gerhard A Coetzee - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Ye Feng - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Brian E Henderson - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Fredrick Schumacher - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Natalia V Bogdanova - Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
France Labrèche - Département de Médecine Sociale et Préventive, Département de Santé Environnementale et Santé au Travail, Université de Montréal, Montreal, Quebec, Canada
Martine Dumont - Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada
Cheng Har Yip - Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya, Kuala Lumpur, Malaysia
Nur Aishah Mohd Taib - Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya, Kuala Lumpur, Malaysia
Ching-Yu Cheng - Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Martha Shrubsole - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Jirong Long - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Katri Pylkäs - Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, Biocenter Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland
Arja Jukkola-Vuorinen - Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland
Saila Kauppila - Department of Pathology, Oulu University Hospital, University of Oulu, Oulu, Finland
Julia A knight - Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Gord Glendon - Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Anna Marie Mulligan - Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Robertus A E M Tollenaar - Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands
Caroline M Seynaeve - Department of Medical Oncology, Erasmus University Medical Center–Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands
Mieke Kriege - Department of Medical Oncology, Erasmus University Medical Center–Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands
Maartje J Hooning - Department of Medical Oncology, Erasmus University Medical Center–Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands
Ans M W Van den Ouweland - Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
Carolien H M Van Deurzen - Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands
Wei Lu - Shanghai Center for Disease Control and Prevention, Shanghai, China
Yu-Tang Gao - Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
Hui Cai - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Sabapathy P Balasubramanian - Cancer Research UK/Yorkshire Cancer Research Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK
Simon S Cross - Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK
Malcolm W R Reed - Cancer Research UK/Yorkshire Cancer Research Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK
Lisa Signorello - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Qiuyin Cai - Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
Mitul Shah - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Hui Miao - Saw Swee Hock School of Public Health, National University of Singapore, Singapore
Ching Wan Chan - Department of Surgery, National University Health System, Singapore
Kee Seng Chia - Saw Swee Hock School of Public Health, National University of Singapore, Singapore
Anna Jakubowska - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Katarzyna Jaworska - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Katarzyna Durda - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Chia-Ni Hsiung - Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Pei-Ei Wu - Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Jyh-Cherng Yu - Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan
Alan Ashworth - Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
Michael Jones - Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Daniel C Tessier - McGill University and Génome Québec Innovation Centre, Montreal, Québec, Canada
Anna González-Neira - Human Genotyping Unit–CEGEN, Human Cancer Genetics Programme, CNIO, Madrid, Spain
Guillermo Pita - Human Genotyping Unit–CEGEN, Human Cancer Genetics Programme, CNIO, Madrid, Spain
M Rosario Alonso - Human Genotyping Unit–CEGEN, Human Cancer Genetics Programme, CNIO, Madrid, Spain
Daniel Vincent - McGill University and Génome Québec Innovation Centre, Montreal, Québec, Canada
Francois Bacot - McGill University and Génome Québec Innovation Centre, Montreal, Québec, Canada
Christine B Ambrosone - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA
Elisa V Bandera - The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
Esther M John - Cancer Prevention Institute of California, Fremont, California, USA
Gary K Chen - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Jennifer J Hu - Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA
Jorge L Rodriguez-gil - Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA
Leslie Bernstein - Division of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, Duarte, California, USA
Michael F Press - Department of Pathology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Regina G Ziegler - Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Robert M Millikan - Department of Epidemiology, Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA
Sandra L Deming-Halverson - Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Sarah Nyante - Department of Epidemiology, Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA
Sue A Ingles - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Quinten Waisfisz - Section of Oncogenetics, Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
Helen Tsimiklis - Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia
Enes Makalic - School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia
Daniel Schmidt - School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia
Minh Bui - School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia
Lorna Gibson - Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
Bertram Müller-Myhsok - Statistical Genetics Research Group, Max Planck Institute of Psychiatry, Munich, Germany
Rita K Schmutzler - Centre of Hereditary Breast and Ovarian Cancer, University Hospital, Cologne, Germany
Rebecca Hein - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Norbert Dahmen - Department of Psychiatry, University of Mainz, Mainz, Germany
Lars Beckmann - Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany
Kirsimari Aaltonen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Kamila Czene - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Astrid Irwanto - Human Genetics Division, Genome Institute of Singapore, Singapore
Jianjun Liu - Human Genetics Division, Genome Institute of Singapore, Singapore
Clare Turnbull - Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Nazneen Rahman - Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Hanne Meijers-Heijboer - Section of Oncogenetics, Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
Andre G Uitterlinden - Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Fernando Rivadeneira - Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Curtis Olswold - Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Irene Konstantopoulou - Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products (IRRP), National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece
Susan Slager - Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Nicholas G Martin - QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Robert Pilarski - Department of Internal Medicine, James Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
Grant W Montgomery - QIMR GWAS Collective, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Foluso Ademuyiwa - Roswell Park Cancer Institute, Buffalo, New York, USA
Dennis J Slamon - Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Claudia Rauh - Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Erlangen, Germany
Michael P Lux - Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Erlangen, Germany
Sebastian M Jud - Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Erlangen, Germany
Thomas Bruning - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany
Joellen Weaver - Biosample Repository, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Priyanka Sharma - Division of Hematology and Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Harsh Pathak - Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Will Tapper - Faculty of Medicine, University of Southampton, Southampton, UK
Sue Gerty - Faculty of Medicine, University of Southampton, Southampton, UK
Lorraine Durcan - Faculty of Medicine, University of Southampton, Southampton, UK
Dimitrios Trichopoulos - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Rosario Tumino - Cancer Registry, Histopathology Unit Civile MPArezzo Hospital, Ragusa, Italy
Petra H Peeters - Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
Rudolf Kaaks - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Daniele Campa - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Federico Canzian - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Elisabete Weiderpass - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Mattias Johansson - Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
Kay-Tee Khaw - Clinical Gerontology Unit, University of Cambridge, Cambridge, UK
Ruth Travis - Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Françoise Clavel-Chapelon - University Paris–Sud, Unité Mixte de Recherche Scientifique (UMRS) 1018, Villejuif, France
Laurence N Kolonel - Département de Médecine Sociale et Préventive, Département de Santé Environnementale et Santé au Travail, Université de Montréal, Montreal, Quebec, Canada
Constance Chen - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Andy Beck - Department of Pathology, Beth Israel DeaconessMedical Center, Boston, Massachusetts, USA
Susan E Hankinson - Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, USA
Christine D Berg - Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA
Robert N Hoover - Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, M Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Jonine D Figueroa - Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Daniel I Chasman - Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Mia M Gaudet - Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
W Ryan Diver - Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
Walter C Willett - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
David J Hunter - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Jacques Simard - Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada
Javier Benitez - Human Genotyping Unit–CEGEN, Human Cancer Genetics Programme, CNIO, Madrid, Spain
Alison M Dunning - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Mark E Sherman - Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Georgia Chenevix-Trench - Department of Genetics, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Stephen J Chanock - Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Per Hall - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Paul D P Pharoah - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
KConFab Investigators
Celine Vachon - Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
Douglas F Easton - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Christopher A Haiman - Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA
Peter Kraft - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Publication Details: Nature genetics, Vol.45(4), pp.392-398e2
Date published: 04/2013
Grant note: R01 CA063464 || CA / National Cancer Institute : NCI R01 CA148667 || CA / National Cancer Institute : NCI R01 CA077305 || CA / National Cancer Institute : NCI R01 CA132839 || CA / National Cancer Institute : NCI R01 CA128978 || CA / National Cancer Institute : NCI U01 CA069446 || CA / National Cancer Institute : NCI R01 CA100374 || CA / National Cancer Institute : NCI R01 CA073629 || CA / National Cancer Institute : NCI K05 CA136967 || CA / National Cancer Institute : NCI R01 CA064277 || CA / National Cancer Institute : NCI U01 CA069631 || CA / National Cancer Institute : NCI R01 CA100598 || CA / National Cancer Institute : NCI R01 CA058860 || CA / National Cancer Institute : NCI P50 CA116201 || CA / National Cancer Institute : NCI R37 CA054281 || CA / National Cancer Institute : NCI R01 CA122340 || CA / National Cancer Institute : NCI U01 CA069638 || CA / National Cancer Institute : NCI R01 CA136924 || CA / National Cancer Institute : NCI K07 CA092044 || CA / National Cancer Institute : NCI R37 CA070867 || CA / National Cancer Institute : NCI U01 CA069417 || CA / National Cancer Institute : NCI U01 CA098758 || CA / National Cancer Institute : NCI
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031666199104646