Genome-wide significant risk associations for mucinous ovarian carcinoma

Linda E Kelemen; Kate Lawrenson; Jonathan Tyrer; Qiyuan Li; Janet M. Lee; Ji-Heui Seo; Catherine M Phelan; Jonathan Beesley; Xiaoqin Chen; Tassja J Spindler; Katja K.H Aben; Hoda Anton-Culver; Natalia Antonenkova; Helen Baker; Elisa V Bandera; Yukie Bean; Matthias W Beckmann; Maria Bisogna; Line Bjorge; Natalia Bogdanova; Louise A Brinton; Angela Brooks-Wilson; Fiona Bruinsma; Ralf Butzow; Ian G Campbell; Karen Carty; Jenny Chang-Claude; Y. Ann Chen; Zhihua Chen; Linda S Cook; Daniel W Cramer; Julie M Cunningham; Cezary Cybulski; Agnieszka Dansonka-Mieszkowska; Joe Dennis; Ed Dicks; Jennifer A Doherty; Thilo Dörk; Andreas du Bois; Matthias Dürst; Diana Eccles; Douglas T Easton; Robert P Edwards; Ursula Eilber; Arif B Ekici; Svend Aage Engelholm; Peter A Fasching; Brooke L Fridley; Yu-Tang Gao; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind Glasspool; Ellen L Goode; Marc T Goodman; Jacek Grownwald; Patricia Harrington; Philipp Harter; Hanis Nazihah Hasmad; Alexander Hein; Florian Heitz; Michelle A.T Hildebrandt; Peter Hillemanns; Estrid Hogdall; Claus Hogdall; Satoyo Hosono; Edwin S Iversen; Anna Jakubowska; Allan Jensen; Bu-Tian Ji; Beth Y Karlan; Melissa Kellar; Joseph L Kelley; Lambertus A Kiemeney; Camilla Krakstad; Susanne K Kjaer; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Nhu D Le; Alice W Lee; Shashi Lele; Arto Leminen; Jenny Lester; Douglas A Levine; Dong Liang; Jolanta Lissowska; Karen Lu; Jan Lubinski; Lene Lundvall; Leon F.A.G Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Iain McNeish; Usha Menon; Francesmary Modugno; Joanna Moes-Sosnowska; Kirsten B Moysich; Steven A Narod; Lotte Nedergaard; Roberta B Ness; Heli Nevanlinna; Mat Adenan Noor Azmi; Kunle Odunsi; Sara H Olson; Irene Orlow; Sandra Orsulic; Rachel Palmieri Weber; James Paul; Celeste Leigh Pearce; Tanja Pejovic; Liisa M Pelttari; Jennifer Permuth-Wey; Malcolm C Pike; Elizabeth M Poole; Susan J Ramus; Harvey A Risch; Barry Rosen; Anja Rudolph; Mary Anne Rossing; Joseph H Rothstein; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Joellen M Schildkraut; Ira Schwaab; Xiao-Ou Shu; Yurii B Shvetsov; Nadeem Siddiqui; Weiva Sieh; Honglin Song; Melissa C Southey; Lara Sucheston; Ingvild L Tangen; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Shelley S Tworoger; Anne M van Altena; Els Van Nieuwenhuysen; Ignace Vergote; Robert A Vierkant; Shan Wang-Gohrke; Christine Walsh; Nicolas Wentzensen; Alice S Whittemore; Kristine G Wicklund; Lynne R Wilkens; Sawicki Wlodzimierz; Yin-Ling Woo; Xifeng Wu; Anna H Wu; Hannah Yang; Wei Zheng; Argyrios Ziogas; Thomas A Sellers; Matthew L Freedman; Georgia Chenevix-Trench; Paul D Pharoah; Australian Ovarian Canc Study Grp; Simon A Gayther; Andrew Berchuck

doi:10.1038/ng.3336

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Genome-wide significant risk associations for mucinous ovarian carcinoma

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Genome-wide significant risk associations for mucinous ovarian carcinoma

Linda E Kelemen, Kate Lawrenson, Jonathan Tyrer, Qiyuan Li, Janet M. Lee, Ji-Heui Seo, Catherine M Phelan, Jonathan Beesley, Xiaoqin Chen, Tassja J Spindler, …

Nature genetics, Vol.47(8), pp.888-897

08/2015

DOI: https://doi.org/10.1038/ng.3336

PMCID: PMC4520768

PMID: 26075790

Abstract

Genome-wide association studies have identified several risk associations for ovarian carcinomas (OC) but not for mucinous ovarian carcinomas (MOC). Genotypes from OC cases and controls were imputed into the 1000 Genomes Project reference panel. Analysis of 1,644 MOC cases and 21,693 controls identified three novel risk associations: rs752590 at 2q13 (P = 3.3 × 10 −8 ), rs711830 at 2q31.1 (P = 7.5 × 10 −12 ) and rs688187 at 19q13.2 (P = 6.8 × 10 −13 ). Expression Quantitative Trait Locus (eQTL) analysis in ovarian and colorectal tumors (which are histologically similar to MOC) identified significant eQTL associations for HOXD9 at 2q31.1 in ovarian (P = 4.95 × 10 −4 , FDR = 0.003) and colorectal (P = 0.01, FDR = 0.09) tumors, and for PAX8 at 2q13 in colorectal tumors (P = 0.03, FDR = 0.09). Chromosome conformation capture analysis identified interactions between the HOXD9 promoter and risk SNPs at 2q31.1. Overexpressing HOXD9 in MOC cells augmented the neoplastic phenotype. These findings provide the first evidence for MOC susceptibility variants and insights into the underlying biology of the disease.

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Title: Genome-wide significant risk associations for mucinous ovarian carcinoma
Creators: Linda E Kelemen - Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA
Kate Lawrenson - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Jonathan Tyrer - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Qiyuan Li - Medical College, Xiamen University, Xiamen, China
Janet M. Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Ji-Heui Seo - Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA
Catherine M Phelan - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Jonathan Beesley - Department of Cancer Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
Xiaoqin Chen - Department of Cancer Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
Tassja J Spindler - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Katja K.H Aben - Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands
Hoda Anton-Culver - Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California, USA
Natalia Antonenkova - Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus
Helen Baker - The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Elisa V Bandera - Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, The State University of New Jersey, New Brunswick, NJ, USA
Yukie Bean - Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA
Matthias W Beckmann - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany
Maria Bisogna - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Line Bjorge - Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway
Natalia Bogdanova - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Angela Brooks-Wilson - Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada
Fiona Bruinsma - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia
Ralf Butzow - Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Ian G Campbell - Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC, Australia
Karen Carty - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK
Jenny Chang-Claude - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Y. Ann Chen - Department of Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Zhihua Chen - Department of Biostatistics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Linda S Cook - Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA
Daniel W Cramer - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA
Cezary Cybulski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Agnieszka Dansonka-Mieszkowska - Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Joe Dennis - The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Ed Dicks - The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Jennifer A Doherty - Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Thilo Dörk - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
Andreas du Bois - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany
Matthias Dürst - Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany
Diana Eccles - Faculty of Medicine, University of Southampton, Southampton, UK
Douglas T Easton - The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Robert P Edwards - Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology and Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA
Ursula Eilber - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Arif B Ekici - Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen, Germany
Svend Aage Engelholm - Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Peter A Fasching - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany
Brooke L Fridley - Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA
Yu-Tang Gao - Shanghai Cancer Institute, Shanghai, China
Aleksandra Gentry-Maharaj - Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, London, UK
Graham G Giles - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia
Rosalind Glasspool - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK
Ellen L Goode - Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA
Marc T Goodman - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Jacek Grownwald - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Patricia Harrington - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Philipp Harter - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany
Hanis Nazihah Hasmad - Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia
Alexander Hein - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany
Florian Heitz - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang. Huyssens-Stiftung/ Knappschaft GmbH, Essen, Germany
Michelle A.T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Peter Hillemanns - Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
Estrid Hogdall - Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Claus Hogdall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Edwin S Iversen - Department of Statistical Science, Duke University, Durham, NC, USA
Anna Jakubowska - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Allan Jensen - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Centre, Copenhagen, Denmark
Bu-Tian Ji - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Melissa Kellar - Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA
Joseph L Kelley - Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology and Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA
Lambertus A Kiemeney - Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands
Camilla Krakstad - Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway
Susanne K Kjaer - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Centre, Copenhagen, Denmark
Jolanta Kupryjanczyk - Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Diether Lambrechts - Vesalius Research Center, University of Leuven, Leuven, Belgium
Sandrina Lambrechts - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Nhu D Le - Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC, Canada
Alice W Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Shashi Lele - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
Arto Leminen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Jenny Lester - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Douglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Karen Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Jan Lubinski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Lene Lundvall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Leon F.A.G Massuger - Radboud University Medical Centre, Department of Obstetrics and Gynecology, Nijmegen, The Netherlands
Keitaro Matsuo - Department of Preventive Medicine, Kyushu University Faculty of Medical Science, Nagoya, Aichi, Japan
Valerie McGuire - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
John R McLaughlin - Public Health Ontario, Toronto, ON, Canada
Iain McNeish - Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK
Usha Menon - Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, London, UK
Francesmary Modugno - Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology and Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA
Joanna Moes-Sosnowska - Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
Steven A Narod - Women's College Research Institute, University of Toronto, Toronto, ON, Canada
Lotte Nedergaard - Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Roberta B Ness - The University of Texas School of Public Health, Houston, TX, USA
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Mat Adenan Noor Azmi - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Kunle Odunsi - Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA
Sara H Olson - Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA
Irene Orlow - Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA
Sandra Orsulic - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Rachel Palmieri Weber - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
James Paul - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK
Celeste Leigh Pearce - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Tanja Pejovic - Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA
Liisa M Pelttari - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Jennifer Permuth-Wey - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Malcolm C Pike - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Elizabeth M Poole - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Susan J Ramus - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA
Barry Rosen - Department of Obstetrics and Gynecology, University of Toronto, ON, Canada
Anja Rudolph - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Joseph H Rothstein - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
Ingo B Runnebaum - Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany
Iwona K Rzepecka - Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Helga B Salvesen - Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway
Joellen M Schildkraut - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
Ira Schwaab - Praxis für Humangenetik, Wiesbaden, Germany
Xiao-Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA
Nadeem Siddiqui - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK
Weiva Sieh - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
Honglin Song - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Melissa C Southey - Department of Pathology, University of Melbourne, Melbourne, VIC, Australia
Lara Sucheston - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
Ingvild L Tangen - Department of Gynecology and Obstetrics, Haukeland University Horpital, Bergen, Norway
Soo-Hwang Teo - Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia
Kathryn L Terry - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Pamela J Thompson - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Shelley S Tworoger - Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Anne M van Altena - Radboud University Medical Centre, Department of Obstetrics and Gynecology, Nijmegen, The Netherlands
Els Van Nieuwenhuysen - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Ignace Vergote - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium
Robert A Vierkant - Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA
Shan Wang-Gohrke - Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
Christine Walsh - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Alice S Whittemore - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA, USA
Kristine G Wicklund - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA
Sawicki Wlodzimierz - Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland
Yin-Ling Woo - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Hannah Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Wei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Argyrios Ziogas - Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California, USA
Thomas A Sellers - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Matthew L Freedman - Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA
Georgia Chenevix-Trench - Department of Cancer Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
Paul D Pharoah - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Australian Ovarian Canc Study Grp
Simon A Gayther - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
Publication Details: Nature genetics, Vol.47(8), pp.888-897
Date published: 08/2015
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665588504646