HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes in Mycobacterium tuberculosis Superoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase

Yuzhi Dong; Sandra Demaria; Xuming Sun; Fabio R Santori; Bill M Jesdale; Anne S De Groot; William N Rom; Yuri Bushkin

doi:10.1128/IAI.72.4.2412-2415.2004

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HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes in Mycobacterium tuberculosis Superoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase

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HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes in Mycobacterium tuberculosis Superoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase

Yuzhi Dong, Sandra Demaria, Xuming Sun, Fabio R Santori, Bill M Jesdale, Anne S De Groot, William N Rom and Yuri Bushkin

Infection and immunity, Vol.72(4), pp.2412-2415

04/2004

DOI: https://doi.org/10.1128/IAI.72.4.2412-2415.2004

PMCID: PMC375155

PMID: 15039371

Abstract

Microbial Immunity and Vaccines

Major histocompatibility complex class I-restricted CD8 + cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), l -alanine dehydrogenase (AlaDH), and l -glutamine synthetase (GlnS) proteins.

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Title: HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes in Mycobacterium tuberculosis Superoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase
Creators: Yuzhi Dong - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
Sandra Demaria - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
Xuming Sun - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
Fabio R Santori - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
Bill M Jesdale - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
Anne S De Groot - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
William N Rom - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
Yuri Bushkin - Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103
Publication Details: Infection and immunity, Vol.72(4), pp.2412-2415
Date published: 04/2004
Publisher: American Society for Microbiology
Academic Unit: Public Health Research Institute
Language: English
Resource Type: Journal article
Identifiers: 991031665240104646