Helicobacter pylori Seropositivity as a Risk Factor for Pancreatic Cancer

Rachael Z Stolzenberg-Solomon; Martin J Blaser; Paul J Limburg; Guillermo Perez-Perez; Philip R Taylor; Jarmo Virtamo; Demetrius Albanes; ATBC Study

doi:10.1093/jnci/93.12.937

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Helicobacter pylori Seropositivity as a Risk Factor for Pancreatic Cancer

Journal article

Open access

Helicobacter pylori Seropositivity as a Risk Factor for Pancreatic Cancer

Rachael Z Stolzenberg-Solomon, Martin J Blaser, Paul J Limburg, Guillermo Perez-Perez, Philip R Taylor, Jarmo Virtamo, Demetrius Albanes and ATBC Study

JNCI : Journal of the National Cancer Institute, Vol.93(12), pp.937-941

06/20/2001

DOI: https://doi.org/10.1093/jnci/93.12.937

PMID: 11416115

Abstract

Background: Pancreatic cancer is among the most fatal cancers worldwide and one for which few preventable risk factors have been established. Gastric carriage of Helicobacter pylori, particularly cytotoxin-associated gene-A-positive (CagA+) strains, is known to be a risk factor for peptic ulcer disease and gastric cancer and may have a similar etiologic relationship with pancreatic cancer. Methods: We investigated the association of H. pylori carriage and exocrine pancreatic cancer in a nested case–control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 29 133 male Finnish smokers aged 50–69 years at baseline. Case subjects (n = 121) were matched on date of baseline serum collection, study center, age, trial intervention, and completion of the dietary questionnaire to 226 control subjects who were alive at the time the matching case subject was diagnosed and who remained free of cancer, during up to 10 years of follow-up. Levels of immunoglobulin G antibodies to H. pylori whole-cell and CagA+ antigens from stored baseline serum were measured by enzyme-linked immunosorbent assay. Smoking-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by use of conditional logistic regression. Statistical tests were two-sided. Results: Seroprevalence of H. pylori was 82% and 73% among case and control subjects, respectively. Compared with seronegative subjects, those with H. pylori or CagA+ strains were at statistically significantly elevated risk of pancreatic cancer (OR = 1.87 [95% CI = 1.05 to 3.34]; OR = 2.01 [95% CI = 1.09 to 3.70], respectively). Conclusions: Our findings support a possible role for H. pylori carriage in the development of exocrine pancreatic cancer.

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Title: Helicobacter pylori Seropositivity as a Risk Factor for Pancreatic Cancer
Creators: Rachael Z Stolzenberg-Solomon - Affiliations of authors: R. Z. Stolzenberg-Solomon (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences), P. J. Limburg, P. R. Taylor (Cancer Prevention Studies Branch, Division of Clinical Sciences), D. Albanes (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; M. J. Blaser, Departments of Medicine and Microbiology, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York; G. Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine; J. Virtamo, National Public Health Institute, Helsinki, Finland
Martin J Blaser - Affiliations of authors: R. Z. Stolzenberg-Solomon (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences), P. J. Limburg, P. R. Taylor (Cancer Prevention Studies Branch, Division of Clinical Sciences), D. Albanes (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; M. J. Blaser, Departments of Medicine and Microbiology, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York; G. Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine; J. Virtamo, National Public Health Institute, Helsinki, Finland
Paul J Limburg - Affiliations of authors: R. Z. Stolzenberg-Solomon (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences), P. J. Limburg, P. R. Taylor (Cancer Prevention Studies Branch, Division of Clinical Sciences), D. Albanes (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; M. J. Blaser, Departments of Medicine and Microbiology, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York; G. Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine; J. Virtamo, National Public Health Institute, Helsinki, Finland
Guillermo Perez-Perez - Affiliations of authors: R. Z. Stolzenberg-Solomon (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences), P. J. Limburg, P. R. Taylor (Cancer Prevention Studies Branch, Division of Clinical Sciences), D. Albanes (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; M. J. Blaser, Departments of Medicine and Microbiology, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York; G. Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine; J. Virtamo, National Public Health Institute, Helsinki, Finland
Philip R Taylor - Affiliations of authors: R. Z. Stolzenberg-Solomon (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences), P. J. Limburg, P. R. Taylor (Cancer Prevention Studies Branch, Division of Clinical Sciences), D. Albanes (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; M. J. Blaser, Departments of Medicine and Microbiology, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York; G. Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine; J. Virtamo, National Public Health Institute, Helsinki, Finland
Jarmo Virtamo - Affiliations of authors: R. Z. Stolzenberg-Solomon (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences), P. J. Limburg, P. R. Taylor (Cancer Prevention Studies Branch, Division of Clinical Sciences), D. Albanes (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; M. J. Blaser, Departments of Medicine and Microbiology, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York; G. Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine; J. Virtamo, National Public Health Institute, Helsinki, Finland
Demetrius Albanes - Affiliations of authors: R. Z. Stolzenberg-Solomon (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics and Cancer Prevention Studies Branch, Division of Clinical Sciences), P. J. Limburg, P. R. Taylor (Cancer Prevention Studies Branch, Division of Clinical Sciences), D. Albanes (Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics), National Cancer Institute, Bethesda, MD; M. J. Blaser, Departments of Medicine and Microbiology, New York University School of Medicine and Department of Veterans Affairs Medical Center, New York; G. Perez-Perez, Departments of Medicine and Microbiology, New York University School of Medicine; J. Virtamo, National Public Health Institute, Helsinki, Finland
ATBC Study
Publication Details: JNCI : Journal of the National Cancer Institute, Vol.93(12), pp.937-941
Date published: 06/20/2001
Publisher: Oxford University Press
Academic Unit: Center for Advanced Biotechnology and Medicine
Language: English
Resource Type: Journal article
Identifiers: 991031665555404646