Helminth infection promotes colonization resistance via type 2 immunity

Deepshika Ramanan; Rowann Bowcutt; Soo Ching Lee; Mei San Tang; Zachary D Kurtz; Yi Ding; Kenya Honda; William C Gause; Martin J Blaser; Richard A Bonneau; Yvonne A L Lim; P'ng Loke; Ken Cadwell

doi:10.1126/science.aaf3229

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Helminth infection promotes colonization resistance via type 2 immunity

Journal article

Open access

Peer reviewed

Helminth infection promotes colonization resistance via type 2 immunity

Deepshika Ramanan, Rowann Bowcutt, Soo Ching Lee, Mei San Tang, Zachary D Kurtz, Yi Ding, Kenya Honda, William C Gause, Martin J Blaser, Richard A Bonneau, …

Science (American Association for the Advancement of Science), Vol.352(6285), pp.608-612

04/29/2016

DOI: https://doi.org/10.1126/science.aaf3229

PMCID: PMC4905769

PMID: 27080105

Abstract

Animals

Bacteroides - immunology

Bacteroides Infections - immunology

Clostridiales - immunology

Clostridium Infections - immunology

Crohn Disease - genetics

Crohn Disease - immunology

Gastrointestinal Microbiome - immunology

Genetic Predisposition to Disease

Hygiene Hypothesis

Intestines - immunology

Intestines - microbiology

Intestines - parasitology

Mice

Mice, Mutant Strains

Nod2 Signaling Adaptor Protein - genetics

Trichuriasis - immunology

Trichuris - immunology

Increasing incidence of inflammatory bowel diseases, such as Crohn's disease, in developed nations is associated with changes to the microbial environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota. We find that helminth infection protects mice deficient in the Crohn's disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides species. Resistance to Bacteroides colonization was dependent on type 2 immunity, which promoted the establishment of a protective microbiota enriched in Clostridiales. Additionally, we show that individuals from helminth-endemic regions harbor a similar protective microbiota and that deworming treatment reduced levels of Clostridiales and increased Bacteroidales. These results support a model of the hygiene hypothesis in which certain individuals are genetically susceptible to the consequences of a changing microbial environment.

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Title: Helminth infection promotes colonization resistance via type 2 immunity
Creators: Deepshika Ramanan - Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA
Rowann Bowcutt - Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA
Soo Ching Lee - Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Mei San Tang - Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA
Zachary D Kurtz - Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY 10016, USA. Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA
Yi Ding - Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA
Kenya Honda - RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa 230-0045, Japan. Japan Agency for Medical Research and Development (AMED)-Core Research for Evolutional Science and Technology (CREST), Tokyo 100-0004, Japan
William C Gause - Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07101, USA
Martin J Blaser - Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA
Richard A Bonneau - Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA. Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, USA. Simons Center for Data Analysis, Simons Foundation, New York, NY 10011, USA
Yvonne A L Lim - Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. ken.cadwell@med.nyu.edu png.loke@nyumc.org limailian@um.edu.my
P'ng Loke - Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA. ken.cadwell@med.nyu.edu png.loke@nyumc.org limailian@um.edu.my
Ken Cadwell - Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. Departments of Microbiology and Medicine, New York University School of Medicine, New York, NY 10016, USA. ken.cadwell@med.nyu.edu png.loke@nyumc.org limailian@um.edu.my
Publication Details: Science (American Association for the Advancement of Science), Vol.352(6285), pp.608-612
Date published: 04/29/2016
Grant note: DK090989 / NIDDK NIH HHS R01 DK103788 / NIDDK NIH HHS R01 AI093811 / NIAID NIH HHS R01 DK093668 / NIDDK NIH HHS R01 DK090989 / NIDDK NIH HHS R01 AI107588 / NIAID NIH HHS T32 AI007180 / NIAID NIH HHS UL1 TR001445 / NCATS NIH HHS P30CA016087 / NCI NIH HHS AI107588 / NIAID NIH HHS HL123340 / NHLBI NIH HHS UL1 TR00038 / NCATS NIH HHS DK093668 / NIDDK NIH HHS AI007180 / NIAID NIH HHS AI093811 / NIAID NIH HHS R01 HL123340 / NHLBI NIH HHS DK103788 / NIDDK NIH HHS UL1 TR000038 / NCATS NIH HHS P30 CA016087 / NCI NIH HHS
Academic Unit: Office of Research (NJMS); Center for Advanced Biotechnology and Medicine
Language: English
Resource Type: Journal article
Identifiers: 991031666061404646