Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

Jennifer Permuth-Wey; Kate Lawrenson; Howard C Shen; Aneliya Velkova; Jonathan P Tyrer; Zhihua Chen; Hui-Yi Lin; Y. Ann Chen; Ya-Yu Tsai; Xiaotao Qu; Susan J Ramus; Rod Karevan; Janet Lee; Nathan Lee; Melissa C Larson; Katja K Aben; Hoda Anton-Culver; Natalia Antonenkova; Antonis Antoniou; Sebastian M Armasu; François Bacot; Laura Baglietto; Elisa V Bandera; Jill Barnholtz-Sloan; Matthias W Beckmann; Michael J Birrer; Greg Bloom; Natalia Bogdanova; Louise A Brinton; Angela Brooks-Wilson; Robert Brown; Ralf Butzow; Qiuyin Cai; Ian Campbell; Jenny Chang-Claude; Stephen Chanock; Georgia Chenevix-Trench; Jin Q Cheng; Mine S Cicek; Gerhard A Coetzee; Linda S Cook; Fergus J Couch; Daniel W Cramer; Julie M Cunningham; Agnieszka Dansonka-Mieszkowska; Evelyn Despierre; Jennifer A Doherty; Thilo Dörk; Andreas du Bois; Matthias Dürst; Douglas F Easton; Diana Eccles; Robert Edwards; Arif B Ekici; Peter A Fasching; David A Fenstermacher; James M Flanagan; Montserrat Garcia-Closas; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind M Glasspool; Jesus Gonzalez-Bosquet; Marc T Goodman; Martin Gore; Bohdan Górski; Jacek Gronwald; Per Hall; Mari K Halle; Philipp Harter; Florian Heitz; Peter Hillemanns; Maureen Hoatlin; Claus K Høgdall; Estrid Høgdall; Satoyo Hosono; Anna Jakubowska; Allan Jensen; Heather Jim; Stanley B Kaye; Kimberly R Kalli; Linda E Kelemen; Lambertus A Kiemeney; Beth Y Karlan; Fumitaka Kikkawa; Gottfried E Konecny; Camilla Krakstad; Susanne Krüger Kjaer; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Johnathan M Lancaster; Nhu D Le; Arto Leminen; Douglas A Levine; Dong Liang; Boon Kiong Lim; Jie Lin; Jolanta Lissowska; Karen H Lu; Jan Lubiński; Galina Lurie; Leon F.A.G Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Usha Menon; Francesmary Modugno; Kirsten B Moysich; Toru Nakanishi; Steven A Narod; Lotte Nedergaard; Roberta B Ness; Heli Nevanlinna; Stefan Nickels; Houtan Noushmehr; Kunle Odunsi; Sara H Olson; Irene Orlow; James Paul; Celeste L Pearce; Tanja Pejovic; Liisa M Pelttari; Malcolm C Pike; Elizabeth M Poole; Paola Raska; Stefan P Renner; Harvey A Risch; Lorna Rodriguez-Rodriguez; Mary Anne Rossing; Anja Rudolph; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Ira Schwaab; Gianluca Severi; Vijayalakshmi Shridhar; Xiao-Ou Shu; Yurii B Shvetsov; Weiva Sieh; Honglin Song; Melissa C Southey; Beata Spiewankiewicz; Daniel Stram; Rebecca Sutphen; Soo-Hwang Teo; Kathryn L Terry; Daniel C Tessier; Pamela J Thompson; Shelley S Tworoger; Anne M van Altena; Ignace Vergote; Robert A Vierkant; Daniel Vincent; Allison F Vitonis; Shan Wang-Gohrke; Rachel Palmieri Weber; Nicolas Wentzensen; Alice S Whittemore; Elisabeth Wik; Lynne R Wilkens; Boris Winterhoff; Yin Ling Woo; Anna H Wu; Yong-Bing Xiang; Hannah P Yang; Wei Zheng; Argyrios Ziogas; Famida Zulkifli; Catherine M Phelan; Edwin Iversen; Joellen M Schildkraut; Andrew Berchuck; Brooke L Fridley; Ellen L Goode; Paul D. P Pharoah; Consortium Investigators Modifiers; Alvaro N.A Monteiro; Thomas A Sellers; Simon A Gayther

doi:10.1038/ncomms2613

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Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

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Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

Jennifer Permuth-Wey, Kate Lawrenson, Howard C Shen, Aneliya Velkova, Jonathan P Tyrer, Zhihua Chen, Hui-Yi Lin, Y. Ann Chen, Ya-Yu Tsai, Xiaotao Qu, …

Nature communications, Vol.4(1), pp.1627-1627

2013

DOI: https://doi.org/10.1038/ncomms2613

PMCID: PMC3709460

PMID: 23535648

Abstract

Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3′ untranslated region at putative microRNA (miRNA) binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA binding site single nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (OR=1.12, P =10 −8 ) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion ( P =10 −10 ). Variation at 17q21.31 associates with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes.

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Title: Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Creators: Jennifer Permuth-Wey - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA, 33612
Kate Lawrenson - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Howard C Shen - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Aneliya Velkova - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA, 33612
Jonathan P Tyrer - Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Zhihua Chen - Department of Biomedical Informatics, Moffitt Cancer Center, Tampa, FL, USA, 33612
Hui-Yi Lin - Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA, 33612
Y. Ann Chen - Department of Biostatistics, Moffitt Cancer Center, Tampa, FL, USA, 33612
Ya-Yu Tsai - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA, 33612
Xiaotao Qu - Department of Biomedical Informatics, Moffitt Cancer Center, Tampa, FL, USA, 33612
Susan J Ramus - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Rod Karevan - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Janet Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Nathan Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Melissa C Larson - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA, 55905
Katja K Aben - Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, HB 6500, Netherlands
Hoda Anton-Culver - Department of Epidemiology, Director of Genetic Epidemiology Research Institute, UCI Center of Medicine, University of California Irvine, Irvine, CA, USA, 92697
Natalia Antonenkova - Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., 223040, Minsk, Belarus
Antonis Antoniou - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Sebastian M Armasu - Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA, 55905
François Bacot - McGill University and Génome Québec Innovation Centre, Montréal (Québec) Canada, H3A 0G1
Laura Baglietto - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Carlton VIC 3053, Australia
Elisa V Bandera - The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA, 08901
Jill Barnholtz-Sloan - Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, 44195
Matthias W Beckmann - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, 91054, Germany
Michael J Birrer - Massachusetts General Hospital, Boston, MA, USA, 02114
Greg Bloom - Department of Biomedical Informatics, Moffitt Cancer Center, Tampa, FL, USA, 33612
Natalia Bogdanova - Gynaecology Research Unit, Hannover Medical School, Hannover, 30625, Germany
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA, 20892
Angela Brooks-Wilson - Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada, V5Z 1L3
Robert Brown - Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK
Ralf Butzow - Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland, 00530
Qiuyin Cai - Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, 37232
Ian Campbell - Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
Jenny Chang-Claude - German Cancer Research Center, Division of Cancer Epidemiology, 69120, Heidelberg, Germany
Stephen Chanock - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA, 20892
Georgia Chenevix-Trench - Queensland Institute of Medical Research, Brisbane QLD 4006, Australia
Jin Q Cheng - Department of Interdisciplinary Oncology, Moffitt Cancer Center, Tampa, FL, USA, 33612
Mine S Cicek - Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA, 55905
Gerhard A Coetzee - Department of Urology, Microbiology and Preventive Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90089
Linda S Cook - Division Epidemiology and Biostatistics, University of New Mexico, Albuquerque, NM, USA, 87131
Fergus J Couch - Department of Laboratory of Medicine and Pathology, Mayo Clinic, Rochester, MN, USA, 55905
Daniel W Cramer - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, 02115
Julie M Cunningham - Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA, 55905
Agnieszka Dansonka-Mieszkowska - Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland, 02-781
Evelyn Despierre - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium, 3000
Jennifer A Doherty - Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA, 03755
Thilo Dörk - Gynaecology Research Unit, Hannover Medical School, Hannover, 30625, Germany
Andreas du Bois - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, 65199, Wiesbaden, Germany
Matthias Dürst - Department of Gynecology and Obstetrics, Jena University Hospital, 07743, Jena, Germany
Douglas F Easton - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Diana Eccles - Faculty of Medicine, University of Southampton, University Hospital Southampton, SO17 1BJ, UK
Robert Edwards - Maggee Women's Hospital, Pittsburg, PA, USA, 15213
Arif B Ekici - Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, 91054, Erlangen, Germany
Peter A Fasching - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, 91054, Germany
David A Fenstermacher - Department of Biomedical Informatics, Moffitt Cancer Center, Tampa, FL, USA, 33612
James M Flanagan - Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK
Montserrat Garcia-Closas - Sections of Epidemiology and Genetics at the Institute of Cancer Research and Breakthrough Breast Cancer Research Centre, London, UK, SW7 3RP
Aleksandra Gentry-Maharaj - Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, London, NW1 2BU, United Kingdom
Graham G Giles - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Carlton VIC 3053, Australia
Rosalind M Glasspool - The Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, UK
Jesus Gonzalez-Bosquet - Department of Women's Oncology, Moffitt Cancer Center, Tampa, FL, USA, 33612
Marc T Goodman - Samuel Oschin Comprehensive Cancer Center Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA, 90048
Martin Gore - Gynecological Oncology Unit, The Royal Marsden Hospital, London, SW3 6JJ, United Kingdom
Bohdan Górski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, 70-115
Jacek Gronwald - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, 70-115
Per Hall - Department of Epidemiology and Biostatistics, Karolinska Istitutet, Stockholm, Sweden, 171-77
Mari K Halle - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, HB 5006, Norway
Philipp Harter - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, 65199, Wiesbaden, Germany
Florian Heitz - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, 65199, Wiesbaden, Germany
Peter Hillemanns - Clinics of Obstetrics and Gynaecology, Hannover Medical School, 30625, Hannover, Germany
Maureen Hoatlin - Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR, USA, 97239
Claus K Høgdall - The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, 2100, Denmark
Estrid Høgdall - Department of Pathology, Molecular Unit, Herlev Hospital, University of Copenhagen, Denmark, 2730
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan
Anna Jakubowska - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, 70-115
Allan Jensen - Virus, Lifestyle and Genes, Danish Cancer Society Research Center, DK-2100, Copenhagen, Denmark
Heather Jim - Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA, 33612
Stanley B Kaye - Section of Medicine, Institute of Cancer Research, Sutton, SM2 5NG, UK
Kimberly R Kalli - Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA, 55905
Linda E Kelemen - Department of Popluation Health Research, Alberta Health Services-Cancer Care, Calgary, Alberta, Canada and Departments of Medical Genetics and Oncology, University of Calgary, Calgary, AB, Canada, T2N 2T9
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA, 90048
Lambertus A Kiemeney - Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, HB 6500, Netherlands
Fumitaka Kikkawa - Department of Obsterics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan
Gottfried E Konecny - Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA, 90095
Camilla Krakstad - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, HB 5006, Norway
Susanne Krüger Kjaer - The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, 2100, Denmark
Jolanta Kupryjanczyk - Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland, 02-781
Diether Lambrechts - Vesalius Research Center, VIB, 3000, Leuven, Belgium
Sandrina Lambrechts - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium, 3000
Johnathan M Lancaster - Department of Women's Oncology, Moffitt Cancer Center, Tampa, FL, USA, 33612
Nhu D Le - Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, G12 0YN
Arto Leminen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland, 00530
Douglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, 10021
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA, 77044
Boon Kiong Lim - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 59100 Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia
Jie Lin - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, 77030
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, The Maria Sklodowska-Curie Memorial Cancer Center, 02-781, Warsaw, Poland
Karen H Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, 77030
Jan Lubiński - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, 70-115
Galina Lurie - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA, 96813
Leon F.A.G Massuger - Department of Gynaecology, Radboud University Medical Centre, Nijmegen, HB 6500, Netherlands
Keitaro Matsuo - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan
Valerie McGuire - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA, 94305
John R McLaughlin - Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, ON, M5T 3M7, Canada
Usha Menon - Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, London, NW1 2BU, United Kingdom
Francesmary Modugno - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, 77030
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA, 14263
Toru Nakanishi - Department of Gynecologic Oncology, Aichi Cancer Center Central Hospital, Nagoya, Aichi, Nagoya, 464-8681, Japan
Steven A Narod - Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada, M5G 1N8
Lotte Nedergaard - Department of Pathology, Rigshospitalet, University of Copenhagen, 2100, Denmark
Roberta B Ness - The University of Texas School of Public Health, Houston, TX, USA, 77030
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland, 00530
Stefan Nickels - German Cancer Research Center, Division of Cancer Epidemiology, 69120, Heidelberg, Germany
Houtan Noushmehr - Department of Urology, Microbiology and Preventive Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90089
Kunle Odunsi - Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA, 14263
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, 10065
Irene Orlow - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, 10065
James Paul - The Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, UK
Celeste L Pearce - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Tanja Pejovic - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA, 97239
Liisa M Pelttari - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland, 00530
Malcolm C Pike - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Elizabeth M Poole - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA, 02115
Paola Raska - Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, 44195
Stefan P Renner - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, 91054, Germany
Harvey A Risch - Department of Epidemiology and Public Health, Yale University School of Public Health and School of Medicine, New Haven, CT, USA, 06520
Lorna Rodriguez-Rodriguez - The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA, 08901
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, 98109
Anja Rudolph - German Cancer Research Center, Division of Cancer Epidemiology, 69120, Heidelberg, Germany
Ingo B Runnebaum - Department of Gynecology and Obstetrics, Jena University Hospital, 07743, Jena, Germany
Iwona K Rzepecka - Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland, 02-781
Helga B Salvesen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, HB 5006, Norway
Ira Schwaab - Institut für Humangenetik Wiesbaden, 65187, Wiesbaden, Germany
Gianluca Severi - Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Carlton VIC 3053, Australia
Vijayalakshmi Shridhar - Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA, 55905
Xiao-Ou Shu - Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, 37232
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA, 96813
Weiva Sieh - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA, 94305
Honglin Song - Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Melissa C Southey - Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, VIC 3053, Australia
Beata Spiewankiewicz - Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland, 02-781
Daniel Stram - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Rebecca Sutphen - Pediatrics Epidemiology Center, College of Medicine, University of South Florida, Tampa, FL, USA, 33612
Soo-Hwang Teo - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 59100 Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia
Kathryn L Terry - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, 02115
Daniel C Tessier - McGill University and Génome Québec Innovation Centre, Montréal (Québec) Canada, H3A 0G1
Pamela J Thompson - Samuel Oschin Comprehensive Cancer Center Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA, 90048
Shelley S Tworoger - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA, 02115
Anne M van Altena - Department of Gynaecology, Radboud University Medical Centre, Nijmegen, HB 6500, Netherlands
Ignace Vergote - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium, 3000
Robert A Vierkant - Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA, 55905
Daniel Vincent - McGill University and Génome Québec Innovation Centre, Montréal (Québec) Canada, H3A 0G1
Allison F Vitonis - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, 02115
Shan Wang-Gohrke - Department of Obstetrics and Gynecology, University of Ulm, Ulm, 89081, Germany
Rachel Palmieri Weber - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA, 27708
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA, 20892
Alice S Whittemore - Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford CA, USA, 94305
Elisabeth Wik - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, HB 5006, Norway
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, USA, 96813
Boris Winterhoff - Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA, 55905
Yin Ling Woo - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 59100 Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Yong-Bing Xiang - Shanghai Cancer Institute, Shanghai, China, 2200-25
Hannah P Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA, 20892
Wei Zheng - Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, 37232
Argyrios Ziogas - Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California Irvine, Irvine, California, USA, 92697
Famida Zulkifli - Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, 59100 Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia
Catherine M Phelan - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA, 33612
Edwin Iversen - Department of Statistical Science, Duke University, Durham, NC, USA, 27708
Joellen M Schildkraut - Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA, 27708
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke Comprehensive Cancer Center, Durham, NC, USA, 27708
Brooke L Fridley - Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA, 66160
Ellen L Goode - Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA, 55905
Paul D. P Pharoah - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Consortium Investigators Modifiers
Alvaro N.A Monteiro - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA, 33612
Thomas A Sellers - Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, FL, USA, 33612
Simon A Gayther - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, 90033
Publication Details: Nature communications, Vol.4(1), pp.1627-1627
Date published: 2013
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665492404646