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Linking the Enzymes that Unlink DNA
Journal article   Open access  Peer reviewed

Linking the Enzymes that Unlink DNA

Steven J Brill
Molecular cell, Vol.52(2), pp.159-160
10/24/2013
DOI: https://doi.org/10.1016/j.molcel.2013.10.007
PMCID: PMC4126409
PMID: 24210174

Abstract

Animals DNA Repair DNA, Cruciform DNA-Binding Proteins - metabolism Endodeoxyribonucleases - metabolism Endonucleases - metabolism Humans
Two papers in this issue, Castor et al. (2013) and Wyatt et al. (2013), and a third in Cell Reports, Garner et al. (2013), demonstrate that the scaffold protein SLX4 coordinates multiple nucleases in order to effectively resolve Holliday junctions and repair interstrand crosslinks (ICLs) in mammalian cells.
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