Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Abhishek D Garg; Lorenzo Galluzzi; Lionel Apetoh; Thais Baert; Raymond B Birge; José Manuel Bravo-San Pedro; Karine Breckpot; David Brough; Ricardo Chaurio; Mara Cirone; An Coosemans; Pierre G Coulie; Dirk De Ruysscher; Luciana Dini; Peter de Witte; Aleksandra M Dudek-Peric; Alberto Faggioni; Jitka Fucikova; Udo S Gaipl; Jakub Golab; Marie-Lise Gougeon; Michael R Hamblin; Akseli Hemminki; Martin Herrmann; James W Hodge; Oliver Kepp; Guido Kroemer; Dmitri V Krysko; Walter G Land; Frank Madeo; Angelo A Manfredi; Stephen R Mattarollo; Christian Maueroder; Nicolò Merendino; Gabriele Multhoff; Thomas Pabst; Jean-Ehrland Ricci; Chiara Riganti; Erminia Romano; Nicole Rufo; Mark J Smyth; Jürgen Sonnemann; Radek Spisek; John Stagg; Erika Vacchelli; Peter Vandenabeele; Lien Vandenberk; Benoit J Van den Eynde; Stefaan Van Gool; Francesca Velotti; Laurence Zitvogel; Patrizia Agostinis

doi:10.3389/fimmu.2015.00588

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Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Journal article

Open access

Peer reviewed

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Abhishek D Garg, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B Birge, José Manuel Bravo-San Pedro, Karine Breckpot, David Brough, Ricardo Chaurio, Mara Cirone, …

Frontiers in immunology, Vol.6, pp.588-588

2015

DOI: https://doi.org/10.3389/fimmu.2015.00588

PMCID: PMC4653610

PMID: 26635802

Abstract

anti-tumor immunity

immunogenicity

Immunology

immunotherapy

molecular medicine

oncoimmunology

patient prognosis

translational medicine

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called “damage-associated molecular patterns” (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.

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Title: Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
Creators: Abhishek D Garg - Cell Death Research and Therapy Laboratory, Department of Cellular Molecular Medicine, KU Leuven – University of Leuven
Lorenzo Galluzzi - Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers
Lionel Apetoh - U866, INSERM
Thais Baert - Department of Gynaecology and Obstetrics, UZ Leuven
Raymond B Birge - Department of Microbiology, Biochemistry, and Molecular Genetics, University Hospital Cancer Center, Rutgers Cancer Institute of New Jersey, New Jersey Medical School
José Manuel Bravo-San Pedro - Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers
Karine Breckpot - Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel
David Brough - Faculty of Life Sciences, University of Manchester
Ricardo Chaurio - Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nurnberg
Mara Cirone - Department of Experimental Medicine, Sapienza University of Rome
An Coosemans - Department of Gynaecology and Obstetrics, UZ Leuven
Pierre G Coulie - de Duve Institute, Université Catholique de Louvain
Dirk De Ruysscher - Department of Radiation Oncology, University Hospitals Leuven, KU Leuven – University of Leuven
Luciana Dini - Department of Biological and Environmental Science and Technology, University of Salento
Peter de Witte - Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven – University of Leuven
Aleksandra M Dudek-Peric - Cell Death Research and Therapy Laboratory, Department of Cellular Molecular Medicine, KU Leuven – University of Leuven
Alberto Faggioni - Sapienza University of Rome
Jitka Fucikova - SOTIO
Udo S Gaipl - Department of Radiation Oncology, Universitätsklinikum Erlangen
Jakub Golab - Department of Immunology, Medical University of Warsaw
Marie-Lise Gougeon - Biotherapy and Vaccine Unit, Institut Pasteur
Michael R Hamblin - Wellman Center for Photomedicine, Massachusetts General Hospital
Akseli Hemminki - Cancer Gene Therapy Group, Transplantation Laboratory, Haartman Institute, University of Helsinki
Martin Herrmann - Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nurnberg
James W Hodge - Recombinant Vaccine Group, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health
Oliver Kepp - Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers
Guido Kroemer - Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers
Dmitri V Krysko - Molecular Signaling and Cell Death Unit, Inflammation Research Center, VIB
Walter G Land - Molecular ImmunoRheumatology, INSERM UMRS1109, Laboratory of Excellence Transplantex, University of Strasbourg
Frank Madeo - Institute of Molecular Biosciences, NAWI Graz, University of Graz
Angelo A Manfredi - IRRCS Istituto Scientifico San Raffaele, Università Vita-Salute San Raffaele
Stephen R Mattarollo - Translational Research Institute, University of Queensland Diamantina Institute, University of Queensland
Christian Maueroder - Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nurnberg
Nicolò Merendino - Laboratory of Cellular and Molecular Nutrition, Department of Ecological and Biological Sciences, Tuscia University
Gabriele Multhoff - Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München
Thomas Pabst - Department of Medical Oncology, University Hospital
Jean-Ehrland Ricci - INSERM, U1065, Université de Nice-Sophia-Antipolis, Centre Méditerranéen de Médecine Moléculaire (C3M), Équipe “Contrôle Métabolique des Morts Cellulaires”
Chiara Riganti - Department of Oncology, University of Turin
Erminia Romano - Cell Death Research and Therapy Laboratory, Department of Cellular Molecular Medicine, KU Leuven – University of Leuven
Nicole Rufo - Cell Death Research and Therapy Laboratory, Department of Cellular Molecular Medicine, KU Leuven – University of Leuven
Mark J Smyth - Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Insitute
Jürgen Sonnemann - Department of Paediatric Haematology and Oncology, Children’s Clinic, Jena University Hospital
Radek Spisek - SOTIO
John Stagg - Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Institut du Cancer de Montréal, Faculté de Pharmacie, Université de Montréal
Erika Vacchelli - Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers
Peter Vandenabeele - Molecular Signaling and Cell Death Unit, Inflammation Research Center, VIB
Lien Vandenberk - Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, KU Leuven – University of Leuven
Benoit J Van den Eynde - Ludwig Institute for Cancer Research, de Duve Institute, Université Catholique de Louvain
Stefaan Van Gool - Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, KU Leuven – University of Leuven
Francesca Velotti - Department of Ecological and Biological Sciences, Tuscia University
Laurence Zitvogel - Gustave Roussy Comprehensive Cancer Institute
Patrizia Agostinis - Cell Death Research and Therapy Laboratory, Department of Cellular Molecular Medicine, KU Leuven – University of Leuven
Publication Details: Frontiers in immunology, Vol.6, pp.588-588
Date published: 2015
Publisher: Frontiers Media S.A
Academic Unit: Biochemistry (NJMS)
Language: English
Resource Type: Journal article
Identifiers: 991031666033204646