Molecular dynamics of HIV-1 reverse transcriptase indicates increased flexibility upon DNA binding

Journal article

Peer reviewed

Marcela Madrid, Jonathan A Lukin, Jeffry D Madura, Jianping Ding and Edward Arnold

Proteins, structure, function, and bioinformatics, Vol.45(3), pp.176-182

11/15/2001

PMID: 11599020

Abstract

collective motions

HIV-1 RT

molecular modeling

B-factors refinement

unliganded RT

RT complexed to dsDNA and a Fab fragment

correlated

concerted

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Title: Molecular dynamics of HIV-1 reverse transcriptase indicates increased flexibility upon DNA binding
Creators: Marcela Madrid - Pittsburgh Supercomputing Center, Pittsburgh, Pennsylvania
Jonathan A Lukin - Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania
Jeffry D Madura - Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania
Jianping Ding - Center for Advanced Biotechnology and Medicine and Chemistry Department, Rutgers University, Piscataway, New Jersey
Edward Arnold - Center for Advanced Biotechnology and Medicine and Chemistry Department, Rutgers University, Piscataway, New Jersey
Publication Details: Proteins, structure, function, and bioinformatics, Vol.45(3), pp.176-182
Date published: 11/15/2001
Publisher: John Wiley & Sons, Inc
Number of pages: 7
Academic Unit: Center for Advanced Biotechnology and Medicine
Language: English
Resource Type: Journal article
Identifiers: 991031654932004646