Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

Siddhartha P Kar; Jonathan P Tyrer; Qiyuan Li; Kate Lawrenson; Katja K H Aben; Hoda Anton-Culver; Natalia Antonenkova; Georgia Chenevix-Trench; Helen Baker; Elisa V Bandera; Yukie T Bean; Matthias W Beckmann; Andrew Berchuck; Maria Bisogna; Line Bjørge; Natalia Bogdanova; Louise Brinton; Angela Brooks-Wilson; Ralf Butzow; Ian Campbell; Karen Carty; Jenny Chang-Claude; Yian Ann Chen; Zhihua Chen; Linda S Cook; Daniel Cramer; Julie M Cunningham; Cezary Cybulski; Agnieszka Dansonka-Mieszkowska; Joe Dennis; Ed Dicks; Jennifer A Doherty; Thilo Dörk; Andreas du Bois; Matthias Dürst; Diana Eccles; Douglas F Easton; Robert P Edwards; Arif B Ekici; Peter A Fasching; Brooke L Fridley; Yu-Tang Gao; Aleksandra Gentry-Maharaj; Graham G Giles; Rosalind Glasspool; Ellen L Goode; Marc T Goodman; Jacek Grownwald; Patricia Harrington; Philipp Harter; Alexander Hein; Florian Heitz; Michelle A T Hildebrandt; Peter Hillemanns; Estrid Hogdall; Claus K Hogdall; Satoyo Hosono; Edwin S Iversen; Anna Jakubowska; James Paul; Allan Jensen; Bu-Tian Ji; Beth Y Karlan; Susanne K Kjaer; Linda E Kelemen; Melissa Kellar; Joseph Kelley; Lambertus A Kiemeney; Camilla Krakstad; Jolanta Kupryjanczyk; Diether Lambrechts; Sandrina Lambrechts; Nhu D Le; Alice W Lee; Shashi Lele; Arto Leminen; Jenny Lester; Douglas A Levine; Dong Liang; Jolanta Lissowska; Karen Lu; Jan Lubinski; Lene Lundvall; Leon Massuger; Keitaro Matsuo; Valerie McGuire; John R McLaughlin; Iain A McNeish; Usha Menon; Francesmary Modugno; Kirsten B Moysich; Steven A Narod; Lotte Nedergaard; Roberta B Ness; Heli Nevanlinna; Kunle Odunsi; Sara H Olson; Irene Orlow; Sandra Orsulic; Rachel Palmieri Weber; Celeste Leigh Pearce; Tanja Pejovic; Liisa M Pelttari; Jennifer Permuth-Wey; Catherine M Phelan; Malcolm C Pike; Elizabeth M Poole; Susan J Ramus; Harvey A Risch; Barry Rosen; Mary Anne Rossing; Joseph H Rothstein; Anja Rudolph; Ingo B Runnebaum; Iwona K Rzepecka; Helga B Salvesen; Joellen M Schildkraut; Ira Schwaab; Xiao-Ou Shu; Yurii B Shvetsov; Nadeem Siddiqui; Weiva Sieh; Honglin Song; Melissa C Southey; Lara E Sucheston-Campbell; Ingvild L Tangen; Soo-Hwang Teo; Kathryn L Terry; Pamela J Thompson; Agnieszka Timorek; Ya-Yu Tsai; Shelley S Tworoger; Anne M van Altena; Els Van Nieuwenhuysen; Ignace Vergote; Robert A Vierkant; Shan Wang-Gohrke; Christine Walsh; Nicolas Wentzensen; Alice S Whittemore; Kristine G Wicklund; Lynne R Wilkens; Yin-Ling Woo; Xifeng Wu; Anna Wu; Hannah Yang; Wei Zheng; Argyrios Ziogas; Thomas A Sellers; Alvaro N A Monteiro; Matthew L Freedman; Simon A Gayther; Paul D P Pharoah; Australian Ovarian Cancer Study Group

doi:10.1158/1055-9965.EPI-14-1270

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Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

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Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

Siddhartha P Kar, Jonathan P Tyrer, Qiyuan Li, Kate Lawrenson, Katja K H Aben, Hoda Anton-Culver, Natalia Antonenkova, Georgia Chenevix-Trench, Helen Baker, Elisa V Bandera, …

Cancer epidemiology, biomarkers & prevention, Vol.24(10), pp.1574-1584

10/2015

DOI: https://doi.org/10.1158/1055-9965.EPI-14-1270

PMID: 26209509

Abstract

Cystadenocarcinoma, Serous - epidemiology

Cystadenocarcinoma, Serous - genetics

DNA, Neoplasm - genetics

Female

Gene Expression Regulation, Neoplastic

Genetic Predisposition to Disease

Genome-Wide Association Study

Genotype

Humans

Morbidity - trends

Nuclear Proteins

Ovarian Neoplasms - epidemiology

Ovarian Neoplasms - genetics

Risk Factors

Transcription Factors - biosynthesis

Transcription Factors - genetics

Global Health

Genome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative target genes of these TFs as identified by coexpression may also be enriched for additional EOC risk associations. We selected TF genes within 1 Mb of the top signal at the 12 genome-wide significant risk loci. Mutual information, a form of correlation, was used to build networks of genes strongly coexpressed with each selected TF gene in the unified microarray dataset of 489 serous EOC tumors from The Cancer Genome Atlas. Genes represented in this dataset were subsequently ranked using a gene-level test based on results for germline SNPs from a serous EOC GWAS meta-analysis (2,196 cases/4,396 controls). Gene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05). These results were replicated (P < 0.05) using an independent association study (7,035 cases/21,693 controls). Genes underlying enrichment in the six networks were pooled into a combined network. We identified a HOX-centric network associated with serous EOC risk containing several genes with known or emerging roles in serous EOC development. Network analysis integrating large, context-specific datasets has the potential to offer mechanistic insights into cancer susceptibility and prioritize genes for experimental characterization.

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Title: Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk
Creators: Siddhartha P Kar - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. sk718@medschl.cam.ac.uk
Jonathan P Tyrer - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Qiyuan Li - Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts
Kate Lawrenson - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Katja K H Aben - Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands. Comprehensive Cancer Center The Netherlands, Utrecht, the Netherlands
Hoda Anton-Culver - Department of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California
Natalia Antonenkova - Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus
Georgia Chenevix-Trench - Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Helen Baker - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Elisa V Bandera - Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Yukie T Bean - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon
Matthias W Beckmann - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina
Maria Bisogna - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
Line Bjørge - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Natalia Bogdanova - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
Louise Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Angela Brooks-Wilson - Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
Ralf Butzow - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland. Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
Ian Campbell - Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Department of Pathology, University of Melbourne, Parkville, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia
Karen Carty - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Jenny Chang-Claude - German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Yian Ann Chen - Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida
Zhihua Chen - Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida
Linda S Cook - Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico
Daniel Cramer - Obstetrics and Gynecology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Harvard School of Public Health, Boston, Massachusetts
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
Cezary Cybulski - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Agnieszka Dansonka-Mieszkowska - Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Joe Dennis - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Ed Dicks - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Jennifer A Doherty - Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire
Thilo Dörk - Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
Andreas du Bois - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Matthias Dürst - Department of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
Diana Eccles - Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom
Douglas F Easton - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Robert P Edwards - Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom. Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania
Arif B Ekici - University Hospital Erlangen, Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Peter A Fasching - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany. University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California
Brooke L Fridley - Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas
Yu-Tang Gao - Shanghai Cancer Institute, Shanghai, China
Aleksandra Gentry-Maharaj - Women's Cancer, University College London Elizabeth Garrett Anderson Institute for Women's Health, London, United Kingdom
Graham G Giles - Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia
Rosalind Glasspool - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Ellen L Goode - Department of Health Science Research, Mayo Clinic, Rochester, Minnesota
Marc T Goodman - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California. Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California
Jacek Grownwald - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Patricia Harrington - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Philipp Harter - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Alexander Hein - University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany
Florian Heitz - Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany
Michelle A T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Peter Hillemanns - Departments of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
Estrid Hogdall - Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Claus K Hogdall - Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Satoyo Hosono - Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
Edwin S Iversen - Department of Statistical Science, Duke University, Durham, North Carolina
Anna Jakubowska - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
James Paul - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Allan Jensen - Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
Bu-Tian Ji - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California
Susanne K Kjaer - Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Linda E Kelemen - Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina
Melissa Kellar - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon
Joseph Kelley - Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Lambertus A Kiemeney - Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands
Camilla Krakstad - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Jolanta Kupryjanczyk - Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Diether Lambrechts - Vesalius Research Center, VIB, Leuven, Belgium. Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium
Sandrina Lambrechts - Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium
Nhu D Le - Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada
Alice W Lee - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Shashi Lele - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
Arto Leminen - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland
Jenny Lester - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California
Douglas A Levine - Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Karen Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Jan Lubinski - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
Lene Lundvall - Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Leon Massuger - Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands
Keitaro Matsuo - Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan
Valerie McGuire - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California
John R McLaughlin - Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Iain A McNeish - Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, United Kingdom
Usha Menon - Women's Cancer, University College London Elizabeth Garrett Anderson Institute for Women's Health, London, United Kingdom
Francesmary Modugno - Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania. Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
Steven A Narod - Women's College Research Institute, Toronto, Ontario, Canada
Lotte Nedergaard - Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Roberta B Ness - The University of Texas School of Public Health, Houston, Texas
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland
Kunle Odunsi - Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York
Sara H Olson - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
Irene Orlow - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
Sandra Orsulic - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California
Rachel Palmieri Weber - Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina
Celeste Leigh Pearce - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Tanja Pejovic - Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon
Liisa M Pelttari - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland
Jennifer Permuth-Wey - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida
Catherine M Phelan - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida
Malcolm C Pike - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York
Elizabeth M Poole - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
Susan J Ramus - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut
Barry Rosen - Department of Gynecologic-Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Mary Anne Rossing - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington, Seattle, Washington
Joseph H Rothstein - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California
Anja Rudolph - German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Ingo B Runnebaum - Department of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
Iwona K Rzepecka - Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
Helga B Salvesen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Joellen M Schildkraut - Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina. Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina
Ira Schwaab - Institut für Humangenetik Wiesbaden, Wiesbaden, Germany
Xiao-Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii
Nadeem Siddiqui - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom
Weiva Sieh - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California
Honglin Song - Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Melissa C Southey - Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
Lara E Sucheston-Campbell - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York
Ingvild L Tangen - Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
Soo-Hwang Teo - Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Kathryn L Terry - Obstetrics and Gynecology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Harvard School of Public Health, Boston, Massachusetts
Pamela J Thompson - Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California. Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California
Agnieszka Timorek - Department of Obstetrics, Gynecology, and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland
Ya-Yu Tsai - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida
Shelley S Tworoger - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
Anne M van Altena - Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands
Els Van Nieuwenhuysen - Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium
Ignace Vergote - Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium
Robert A Vierkant - Department of Health Science Research, Mayo Clinic, Rochester, Minnesota
Shan Wang-Gohrke - Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
Christine Walsh - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Alice S Whittemore - Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California
Kristine G Wicklund - Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii
Yin-Ling Woo - University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Anna Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Hannah Yang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
Wei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee
Argyrios Ziogas - Department of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California
Thomas A Sellers - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida
Alvaro N A Monteiro - Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida
Matthew L Freedman - Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts
Simon A Gayther - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California
Paul D P Pharoah - Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Australian Ovarian Cancer Study Group
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.24(10), pp.1574-1584
Date published: 10/2015
Grant note: R03 CA113148 / NCI NIH HHS N01 CN025403 / NCI NIH HHS R37 CA070867 / NCI NIH HHS K22 CA138563 / NCI NIH HHS R03 CA115195 / NCI NIH HHS U01 CA069417 / NCI NIH HHS R01 CA063682 / NCI NIH HHS T32 CA009001 / NCI NIH HHS R01 CA058598 / NCI NIH HHS P01 CA017054 / NCI NIH HHS R01 CA067262 / NCI NIH HHS R01 CA080742 / NCI NIH HHS P50 CA105009 / NCI NIH HHS R01 CA083918 / NCI NIH HHS R01 CA074850 / NCI NIH HHS R01 CA054419 / NCI NIH HHS R01 CA064277 / NCI NIH HHS R01 CA136924 / NCI NIH HHS R01 CA076016 / NCI NIH HHS K07 CA092044 / NCI NIH HHS UL1 TR000005 / NCATS NIH HHS K07 CA143047 / NCI NIH HHS P30 CA016056 / NCI NIH HHS R01 CA168758 / NCI NIH HHS R01 CA087538 / NCI NIH HHS R01 CA122443 / NCI NIH HHS T32 ES013678 / NIEHS NIH HHS R01 CA058860 / NCI NIH HHS U19-CA148112 / NCI NIH HHS P30 CA015083 / NCI NIH HHS K07 CA095666 / NCI NIH HHS R01 CA106414 / NCI NIH HHS N01PC35137 / NCI NIH HHS R01 CA112523 / NCI NIH HHS R01 CA149429 / NCI NIH HHS R01 CA114343 / NCI NIH HHS K99 CA184415 / NCI NIH HHS R01 CA087696 / NCI NIH HHS 10124 / Cancer Research UK P50 CA159981 / NCI NIH HHS U19 CA148112 / NCI NIH HHS P30 CA076292 / NCI NIH HHS N01 PC067010 / NCI NIH HHS R25 CA174664 / NCI NIH HHS R01 CA050385 / NCI NIH HHS R01 CA172404 / NCI NIH HHS P30 CA008748 / NCI NIH HHS P50 CA136393 / NCI NIH HHS P30 CA124435 / NCI NIH HHS R01 CA049449 / NCI NIH HHS R13 CA165638 / NCI NIH HHS R01 CA126841 / NCI NIH HHS P30 CA014089 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665511804646