Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits

Sasha Taleban; Dalin Li; Stephan R Targan; Andrew Ippoliti; Steven R Brant; Judy H Cho; Richard H Duerr; John D Rioux; Mark S Silverberg; Eric A Vasiliauskas; Jerome I Rotter; Talin Haritunians; David Q Shih; Marla Dubinsky; Gil Y Melmed; Dermot P B McGovern

doi:10.1093/ecco-jcc/jjv178

Back

Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits

Journal article

Open access

Peer reviewed

Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits

Sasha Taleban, Dalin Li, Stephan R Targan, Andrew Ippoliti, Steven R Brant, Judy H Cho, Richard H Duerr, John D Rioux, Mark S Silverberg, Eric A Vasiliauskas, …

Journal of Crohn's and colitis, Vol.10(1), pp.43-49

01/2016

DOI: https://doi.org/10.1093/ecco-jcc/jjv178

PMCID: PMC6082592

PMID: 26449790

Abstract

Adult

Age Distribution

Aged

Analysis of Variance

Case-Control Studies

Colitis, Ulcerative - diagnosis

Colitis, Ulcerative - epidemiology

Colitis, Ulcerative - genetics

Crohn Disease - diagnosis

Crohn Disease - epidemiology

Crohn Disease - genetics

Databases, Factual

Female

Genetic Predisposition to Disease - epidemiology

Genome-Wide Association Study - methods

Humans

Incidence

Inflammatory Bowel Diseases - diagnosis

Inflammatory Bowel Diseases - epidemiology

Inflammatory Bowel Diseases - genetics

Logistic Models

Male

Middle Aged

Multivariate Analysis

Odds Ratio

Prognosis

Retrospective Studies

Risk Assessment

Sensitivity and Specificity

Severity of Illness Index

Sex Distribution

Uveitis - diagnosis

Uveitis - epidemiology

Uveitis - genetics

Comorbidity

There has been considerable progress in identifying inflammatory bowel disease [IBD] susceptibility genes but little progress in examining the role of genetic variation in the development of the extra-intestinal manifestations [EIMs] of IBD. This study identified clinical, serological, and genetic factors associated with ocular EIMs [O-EIMs] in IBD. We performed a retrospective case-control study of IBD patients, comparing those with and without O-EIMs using the Cedars-Sinai IBD Research Repository and the NIDDK IBD Genetics Consortium Repository. Genotyping was performed using Illumina whole genome platforms. In all, 124 cases and 3328 controls with available clinical data were identified; 103 cases and 2808 controls had genetic data available. Erythema nodosum and peripheral arthritis particularly were common in patients with O-EIMs [p = 2.77 x 10(-13) and p = 2.58 x 10(-13), respectively] with increasing odds ratios for O-EIMs with each additional non-ocular-EIM [for ≥ 2 EIMs, odds ratio 14.72]. Nominal association with O-EIMs was observed at several known IBD susceptibility single nuclear polymorphisms. One locus, containing RBM19, achieved genome-wide level of significance for association with O-EIMs. In IBD, O-EIMs co-occur with musculoskeletal and skin manifestations and, in this study, are nominally associated with known IBD loci. Additional cohorts are needed to verify these results and identify additional genes.

Files and links (1)

url

https://doi.org/10.1093/ecco-jcc/jjv178View

Version of Record (VoR) Open

Metrics

13 Record Views

36 Times Cited - Web of Science

See more details

Details

Title: Ocular Manifestations in Inflammatory Bowel Disease Are Associated with Other Extra-intestinal Manifestations, Gender, and Genes Implicated in Other Immune-related Traits
Creators: Sasha Taleban - Department of Medicine, Division of Gastroenterology, University of Arizona College of Medicine, Tucson, AZ, USA F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Dalin Li - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Stephan R Targan - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Andrew Ippoliti - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Steven R Brant - Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Judy H Cho - Division of Gastroenterology, Mount Sinai Medical Center, New York, NY, USA
Richard H Duerr - Division of Gastroenterology, Hepatology, and Nutrition, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
John D Rioux - Department of Medicine, University of Montreal and Montreal Heart Institute, Montreal, QC, Canada
Mark S Silverberg - Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Eric A Vasiliauskas - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Jerome I Rotter - Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, USA
Talin Haritunians - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
David Q Shih - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Marla Dubinsky - Department of Pediatrics, Division of Gastroenterology, Mount Sinai Medical Center, New York, NY, USA
Gil Y Melmed - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Dermot P B McGovern - F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA Dermot.mcgovern@cshs.org
Publication Details: Journal of Crohn's and colitis, Vol.10(1), pp.43-49
Date published: 01/2016
Grant note: DK046763 / NIDDK NIH HHS U01 DK062431 / NIDDK NIH HHS U01 DK062423 / NIDDK NIH HHS DK062431 / NIDDK NIH HHS DK62429 / NIDDK NIH HHS U01 DK062429 / NIDDK NIH HHS U01 DK062420 / NIDDK NIH HHS DK062420 / NIDDK NIH HHS U01 DK062432 / NIDDK NIH HHS U01 DK062422 / NIDDK NIH HHS DK62422 / NIDDK NIH HHS
Academic Unit: Medicine - Gastroenterology and Hepatology (RWJMS)
Language: English
Resource Type: Journal article
Identifiers: 991031665458704646