Oxytocin is an anabolic bone hormone

Roberto Tamma; Graziana Colaianni; Ling-ling Zhu; Adriana DiBenedetto; Giovanni Greco; Gabriella Montemurro; Nicola Patano; Maurizio Strippoli; Rosaria Vergari; Lucia Mancini; Silvia Colucci; Maria Grano; Roberta Faccio; Xuan Liu; Jianhua Li; Sabah Usmani; Marilyn Bachar; Itai Bab; Katsuhiko Nishimori; Larry J Young; Christoph Buettner; Jameel Iqbal; Li Sun; Mone Zaidi; Alberta Zallone

doi:10.1073/pnas.0901890106

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Oxytocin is an anabolic bone hormone

Roberto Tamma, Graziana Colaianni, Ling-ling Zhu, Adriana DiBenedetto, Giovanni Greco, Gabriella Montemurro, Nicola Patano, Maurizio Strippoli, Rosaria Vergari, Lucia Mancini, …

Proceedings of the National Academy of Sciences - PNAS, Vol.106(17), pp.7149-7154

04/28/2009

DOI: https://doi.org/10.1073/pnas.0901890106

PMCID: PMC2678458

PMID: 19369205

Abstract

bone density

osteoblast

osteoclast

pituitary hormones

Biological Sciences

Osteoporosis

We report that oxytocin (OT), a primitive neurohypophyseal hormone, hitherto thought solely to modulate lactation and social bonding, is a direct regulator of bone mass. Deletion of OT or the OT receptor (Oxtr) in male or female mice causes osteoporosis resulting from reduced bone formation. Consistent with low bone formation, OT stimulates the differentiation of osteoblasts to a mineralizing phenotype by causing the up-regulation of BMP-2, which in turn controls Schnurri-2 and 3 , Osterix , and ATF-4 expression. In contrast, OT has dual effects on the osteoclast. It stimulates osteoclast formation both directly, by activating NF-κB and MAP kinase signaling, and indirectly through the up-regulation of RANK-L. On the other hand, OT inhibits bone resorption by mature osteoclasts by triggering cytosolic Ca 2+ release and NO synthesis. Together, the complementary genetic and pharmacologic approaches reveal OT as a novel anabolic regulator of bone mass, with potential implications for osteoporosis therapy.

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Title: Oxytocin is an anabolic bone hormone
Creators: Roberto Tamma - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Graziana Colaianni - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Ling-ling Zhu - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Adriana DiBenedetto - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Giovanni Greco - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Gabriella Montemurro - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Nicola Patano - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Maurizio Strippoli - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Rosaria Vergari - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Lucia Mancini - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Silvia Colucci - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Maria Grano - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Roberta Faccio - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Xuan Liu - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Jianhua Li - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Sabah Usmani - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Marilyn Bachar - Bone Laboratory, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
Itai Bab - Bone Laboratory, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
Katsuhiko Nishimori - Graduate School of Agricultural Science, Tohoku University, Aoba-ku, Sendai, Miyagi 981-8555 Japan; and
Larry J Young - Center for Behavioral Neuroscience, Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322
Christoph Buettner - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Jameel Iqbal - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Li Sun - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Mone Zaidi - The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029
Alberta Zallone - Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.106(17), pp.7149-7154
Date published: 04/28/2009
Publisher: National Academy of Sciences
Academic Unit: Medicine - Endocrinology, Metabolism and Nutrition (RWJMS)
Language: English
Resource Type: Journal article
Identifiers: 991031665770504646