Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells

Journal article

Peer reviewed

D G Johns, R L Capizzi, A Nahas, A R Cashmore and J R Bertino

Biochemical pharmacology, Vol.19(4), pp.1528-1533

04/1970

PMID: 5284463

Abstract

Adult

Aged

Animals

Biological Transport - drug effects

Cell Line - drug effects

Cell Line - metabolism

Chemical Precipitation

Chromatography

Chromatography, Gel

Deoxyuridine - metabolism

DNA, Neoplasm - biosynthesis

Female

Folic Acid Antagonists - pharmacology

Humans

Hydroxyapatites

Leukemia L1210

Leukemia, Lymphoid - metabolism

Leukemia, Myeloid - enzymology

Leukemia, Myeloid, Acute - enzymology

Leukemia, Myeloid, Acute - metabolism

Leukocytes - enzymology

Methotrexate - metabolism

Methotrexate - pharmacology

Mice

Quaternary Ammonium Compounds

Quinazolines - pharmacology

Spectrophotometry

Sulfates

Tetrahydrofolate Dehydrogenase - blood

Tetrahydrofolate Dehydrogenase - isolation & purification

Tritium

Ultraviolet Rays

19 Record Views

Title: Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells
Creators: D G Johns
R L Capizzi
A Nahas
A R Cashmore
J R Bertino
Publication Details: Biochemical pharmacology, Vol.19(4), pp.1528-1533
Date published: 04/1970
Academic Unit: Bertino Office
Language: English
Resource Type: Journal article
Identifiers: 991031665504004646