Abstract
Byline: Catherine J. Wei, Elisabete Augusto, Catarina A. Gomes, Philipp Singer, Yumei Wang, Detlev Boison, Rodrigo A. Cunha, Benjamin K. Yee, Jiang-Fan Chen Adenosine A.sub.2A receptors (A.sub.2ARs) are enriched in the striatum but are also present at lower levels in the extrastriatal forebrain (i.e., hippocampus, cortex), integrating dopamine, glutamate, and brain-derived neurotrophic factor (BDNF) signaling, and are thus essential for striatal neuroplasticity and fear and anxiety behavior. Author Affiliation: (a) Molecular Neuropharmacology Laboratory, Department of Neurology, and Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts (b) Center for Neuroscience and Cell Biology, CNC-University of Coimbra, Coimbra, Portugal (c) R.S. Dow Neurobiology Laboratories, Legacy Research Institute, Portland, Oregon (d) Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland (e) Faculty of Medicine, University of Coimbra, Coimbra, Portugal Article History: Received 26 March 2012; Revised 15 April 2013; Accepted 2 May 2013 Article Note: (footnote) Authors BKY and J-FC contributed equally to this work.