Abstract
Maternal effects on early postnatal development in mammals are mediated, in part, by milk-borne bioactive factors transmitted from mother to nursing offspring. The term ‘lactocrine’ was coined to describe this mode of signaling. Relaxin (RLX), one of a family of neohormones found in mammals, is detectable in milk from multiple species. In the pig, evidence of bioactive proRLX in colostrum/milk, immunoreactive RLX in the circulation of nursed neonates, and RLX receptor expression in RLX-sensitive neonatal female reproductive tract tissues, established RLX as a prototypical lactocrine-active factor. Observations provided the foundation for the lactocrine hypothesis for maternal programming of postnatal development. Studies designed to test the lactocrine hypothesis provided insights into both short-term effects of milk-borne bioactive factors in the neonate, and long-term consequences of maternal lactocrine programming of endometrial function and fecundity in adults. Thus, RLX led to the ‘Milky Way’.
•Relaxin is a neohormone that evolved in support of viviparity and lactation.•Relaxin is a prototypical milk-borne bioactive factor.•Milk-borne relaxin is delivered to offspring via a lactocrine mechanism.•Lactocrine signaling affects postnatal uterine developmental programming.