Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD Without ID: A Multi-site Study

Cara E Pugliese; Lauren Kenworthy; Vanessa Hus Bal; Gregory L Wallace; Benjamin E Yerys; Brenna B Maddox; Susan W White; Haroon Popal; Anna Chelsea Armour; Judith Miller; John D Herrington; Robert T Schultz; Alex Martin; Laura Gutermuth Anthony

doi:10.1007/s10803-015-2586-3

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Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD Without ID: A Multi-site Study

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Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD Without ID: A Multi-site Study

Cara E Pugliese, Lauren Kenworthy, Vanessa Hus Bal, Gregory L Wallace, Benjamin E Yerys, Brenna B Maddox, Susan W White, Haroon Popal, Anna Chelsea Armour, Judith Miller, …

Journal of autism and developmental disorders, Vol.45(12), pp.3919-3931

12/2015

DOI: https://doi.org/10.1007/s10803-015-2586-3

PMCID: PMC4654671

PMID: 26385796

Abstract

Adolescent

Adult

Algorithms

Autistic Disorder - diagnosis

Child

Diagnostic and Statistical Manual of Mental Disorders

Female

Humans

Middle Aged

Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised algorithm demonstrated increased sensitivity, but lower specificity in the overall sample. Estimates were highest for females, individuals with a verbal IQ below 85 or above 115, and ages 16 and older. Best practice diagnostic procedures should include the Module 4 in conjunction with other assessment tools. Balancing needs for sensitivity and specificity depending on the purpose of assessment (e.g., clinical vs. research) and demographic characteristics mentioned above will enhance its utility.

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Title: Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD Without ID: A Multi-site Study
Creators: Cara E Pugliese - Center for Autism Spectrum Disorders & Children's National Research Institute, Children's National Health System, Washington, DC, USA. CPuglies@ChildrensNational.org
Lauren Kenworthy - Center for Autism Spectrum Disorders & Children's National Research Institute, Children's National Health System, Washington, DC, USA
Vanessa Hus Bal - Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, CA, USA
Gregory L Wallace - Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA
Benjamin E Yerys - Department of Psychiatry, Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA
Brenna B Maddox - Department of Psychology, Virginia Tech, Blacksburg, VA, USA
Susan W White - Department of Psychology, Virginia Tech, Blacksburg, VA, USA
Haroon Popal - Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA
Anna Chelsea Armour - Center for Autism Spectrum Disorders & Children's National Research Institute, Children's National Health System, Washington, DC, USA
Judith Miller - Department of Psychiatry, Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA
John D Herrington - Department of Psychiatry, Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA
Robert T Schultz - Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA
Alex Martin - Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA
Laura Gutermuth Anthony - Center for Autism Spectrum Disorders & Children's National Research Institute, Children's National Health System, Washington, DC, USA
Publication Details: Journal of autism and developmental disorders, Vol.45(12), pp.3919-3931
Date published: 12/2015
Grant note: ZIA MH002920 / Intramural NIH HHS K23MH086111 / NIMH NIH HHS R21 MH092615 / NIMH NIH HHS U54 HD086984 / NICHD NIH HHS ZIA MH002920-05 / Intramural NIH HHS P30 HD040677 / NICHD NIH HHS R21MH092615 / NIMH NIH HHS T32 HD046388-01A2 / NICHD NIH HHS 1K01MH079945-01 / NIMH NIH HHS K23 MH086111 / NIMH NIH HHS RC1 MH088791 / NIMH NIH HHS T32 HD046388 / NICHD NIH HHS P30 HD026979 / NICHD NIH HHS 1-ZIA-MH002920-05 / NIMH NIH HHS K01 MH079945 / NIMH NIH HHS P30HD040677 / NICHD NIH HHS R01MH081873 / NIMH NIH HHS R01 MH081873 / NIMH NIH HHS RC1MH088791 / NIMH NIH HHS
Academic Unit: Applied Psychology (GSAPP)
Language: English
Resource Type: Journal article
Identifiers: 991031665936004646