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SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage
Journal article   Open access  Peer reviewed

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage

Xuehui Hong, Wenyu Liu, Ruipeng Song, Jamie J Shah, Xing Feng, Chi Kwan Tsang, Katherine M Morgan, Samuel F Bunting, Hiroyuki Inuzuka, X F Steven Zheng, …
Nucleic acids research, Vol.44(18), pp.8855-8869
10/14/2016
PMID: 27566146

Abstract

Antineoplastic Agents - pharmacology Cell Cycle Proteins - metabolism Cell Death Cell Line, Tumor DNA Damage - drug effects DNA Damage - radiation effects F-Box Proteins - metabolism F-Box-WD Repeat-Containing Protein 7 Glycogen Synthase Kinase 3 beta - metabolism Humans Models, Biological Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Interaction Domains and Motifs Proteolysis SOX9 Transcription Factor - chemistry SOX9 Transcription Factor - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination Ultraviolet Rays - adverse effects Phosphorylation
url
https://doi.org/10.1093/nar/gkw748View
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