Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

Marshall L MORNINGSTAR; Thomas ROTH; Stephen H HUGHES; Christopher J MICHEJDA; David W FARNSWORTH; Marilyn KROEGER SMITH; Karen WATSON; Robert W BUCKHEIT; Kalyan DAS; WANYI ZHANG; Eddy ARNOLD; John G JULIAS

doi:10.1021/jm060103d

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Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

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Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme

Marshall L MORNINGSTAR, Thomas ROTH, Stephen H HUGHES, Christopher J MICHEJDA, David W FARNSWORTH, Marilyn KROEGER SMITH, Karen WATSON, Robert W BUCKHEIT, Kalyan DAS, WANYI ZHANG, …

Journal of medicinal chemistry, Vol.50(17), pp.4003-4015

2007

DOI: https://doi.org/10.1021/jm060103d

PMCID: PMC3057568

PMID: 17663538

Abstract

Antiviral agents

Biological and medical sciences

Medical sciences

Pharmacology. Drug treatments

Antibiotics. Antiinfectious agents. Antiparasitic agents

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Title: Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme
Creators: Marshall L MORNINGSTAR - Molecular Aspects of Drug Design Section, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, United States
Thomas ROTH - Molecular Aspects of Drug Design Section, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, United States
Stephen H HUGHES - Retroviral Replication Laboratory, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, United States
Christopher J MICHEJDA - Molecular Aspects of Drug Design Section, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, United States
David W FARNSWORTH - Molecular Aspects of Drug Design Section, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, United States
Marilyn KROEGER SMITH - Molecular Aspects of Drug Design Section, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, United States
Karen WATSON - Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701, United States
Robert W BUCKHEIT - Southern Research Institute-Frederick Research Center, 431 Aviation Way, Frederick, Maryland 21701, United States
Kalyan DAS - Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States
WANYI ZHANG - Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States
Eddy ARNOLD - Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States
John G JULIAS - Retroviral Replication Laboratory, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, United States
Publication Details: Journal of medicinal chemistry, Vol.50(17), pp.4003-4015
Date published: 2007
Publisher: American Chemical Society
Academic Unit: Center for Advanced Biotechnology and Medicine
Language: English
Resource Type: Journal article
Identifiers: 991031654716304646