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- Title
- Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors
- Creators
- David R MAGNIN - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Jeffrey A ROBL - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Richard B SULSKY - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400David J AUGERI - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Yanting HUANG - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Ligaya M SIMPKINS - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Prakash C TAUNK - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400David A BETEBENNER - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400James G ROBERTSON - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Benoni E ABBOA-OFFEI - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Aiying WANG - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Michael CAP - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Li XIN - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Li TAO - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Doree F SITKOFF - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Mary F MALLEY - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Jack Z GOUGOUTAS - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Ashish KHANNA - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Qi HUANG - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Song-Ping HAN - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Rex A PARKER - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400Lawrence G HAMANN - Departments of Discovery Chemistry, Metabolic Research, Exploratory Pharmaceutics, Computer-Assisted Drug Design,Solid State Chemistry, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute,P.O. Box 5400, Princeton, New Jersey 08543-5400
- Publication Details
- Journal of medicinal chemistry, Vol.47(10), pp.2587-2598
- Date published
- 05/06/2004
- Publisher
- American Chemical Society
- Academic Unit
- Medicinal Chemistry (EMSOP)
- Language
- English
- Resource Type
- Journal article
- Identifiers
- 991031654539404646