Telomere Dynamics in Macaques and Humans

Jeffrey P Gardner; Masayuki Kimura; Weihang Chai; Jameel F Durrani; Levon Tchakmakjian; Xiaojian Cao; Xiaobin Lu; Guanghui Li; Athanasios P Peppas; Joan Skurnick; Woodring E Wright; Jerry W Shay; Abraham Aviv

doi:10.1093/gerona/62.4.367

Back

Telomere Dynamics in Macaques and Humans

Journal article

Open access

Peer reviewed

Telomere Dynamics in Macaques and Humans

Jeffrey P Gardner, Masayuki Kimura, Weihang Chai, Jameel F Durrani, Levon Tchakmakjian, Xiaojian Cao, Xiaobin Lu, Guanghui Li, Athanasios P Peppas, Joan Skurnick, …

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.62(4), pp.367-374

04/2007

DOI: https://doi.org/10.1093/gerona/62.4.367

PMID: 17452729

Abstract

In humans, telomere length in proliferating tissues shortens with age—a process accelerated with age-related diseases. Thus, telomere length and attrition with age in the nonhuman primate may serve as a useful paradigm for understanding telomere biology in humans. We examined telomere parameters in tissues of young and old Macaca fascicularis and compared them with several tissues from humans. Macaque telomeres were variable in length and exhibited partial synchrony (equivalence) within animals. They were longer than humans, partially because of longer subtelomeric segments. As skeletal muscle telomere length was unchanged with age, we used it as an internal reference to offset interanimal variation in telomere length. We identified age-dependent telomere attrition in lung, pancreas, skin, and thyroid. Similar to humans, telomerase activity was detected in spleen, thymus, digestive tract, and gonads. We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque.

Files and links (1)

url

https://doi.org/10.1093/gerona/62.4.367View

Version of Record (VoR) Open

Metrics

Details

Title: Telomere Dynamics in Macaques and Humans
Creators: Jeffrey P Gardner - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Masayuki Kimura - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Weihang Chai - Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas
Jameel F Durrani - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Levon Tchakmakjian - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Xiaojian Cao - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Xiaobin Lu - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Guanghui Li - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Athanasios P Peppas - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Joan Skurnick - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Woodring E Wright - Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas
Jerry W Shay - Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas
Abraham Aviv - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine & Dentistry of New Jersey Medical School, Newark
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.62(4), pp.367-374
Date published: 04/2007
Publisher: Oxford University Press
Academic Unit: Pediatrics - Developmental-Behavioral Pediatrics (NJMS)
Language: English
Resource Type: Journal article
Identifiers: 991031653876804646