The oyster genome reveals stress adaptation and complexity of shell formation

Guofan Zhang; Xiaodong Fang; Ximing Guo; Ruibang Luo; Li Li; Fei Xu; Pengcheng Yang; Linlin Zhang; Xiaotong Wang; Haigang Qi; Zhiqiang Xiong; Huayong Que; Yinlong Xie; Peter W. H. Holland; Jordi Paps; Yabing Zhu; Fucun Wu; Yuanxin Chen; Jiafeng Wang; Chunfang Peng; Jie Meng; Lan Yang; Jun Liu; Bo Wen; Na Zhang; Zhiyong Huang; Qihui Zhu; Yue Feng; Andrew Mount; Dennis Hedgecock; Zhe Xu; Yunjie Liu; Tomislav Domazet-Lošo; Yishuai Du; Xiaoqing Sun; Shoudu Zhang; Binghang Liu; Peizhou Cheng; Xuanting Jiang; Dingding Fan; Juan Li; Wei Wang; Wenjing Fu; Tong Wang; Bo Wang; Jibiao Zhang; Zhiyu Peng; Yingxiang Li; Na Li; Jinpeng Wang; Maoshan Chen; Yan He; Fengji Tan; Xiaorui Song; Qiumei Zheng; Ronglian Huang; Hailong Yang; Xuedi Du; Li Chen; Mei Yang; Patrick M. Gaffney; Shan Wang; Longhai Luo; Zhicai She; Yao Ming; Wen Huang; Shu Zhang; Baoyu Huang; Yong Zhang; Tao Qu; Peixiang Ni; Guoying Miao; Junyi Wang; Qiang Wang; Christian E. W. Steinberg; Haiyan Wang; Ning Li; Lumin Qian; Guojie Zhang; Huanming Yang; Yingrui Li; Xiao Liu; Jian Wang; Ye Yin; Jun Wang

doi:10.1038/nature11413

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The oyster genome reveals stress adaptation and complexity of shell formation

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The oyster genome reveals stress adaptation and complexity of shell formation

Guofan Zhang, Xiaodong Fang, Ximing Guo, Ruibang Luo, Li Li, Fei Xu, Pengcheng Yang, Linlin Zhang, Xiaotong Wang, Haigang Qi, …

Nature, Vol.490, pp.49-54

09/19/2012

DOI: https://doi.org/10.1038/nature11413

PMID: 22992520

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is highly polymorphic and rich in repetitive sequences, with some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set of genes responding to environmental stress. The expansion of genes coding for heat shock protein 70 and inhibitors of apoptosis is probably central to the oyster's adaptation to sessile life in the highly stressful intertidal zone. Our analyses also show that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. The oyster genome sequence fills a void in our understanding of the Lophotrochozoa.

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Title: The oyster genome reveals stress adaptation and complexity of shell formation
Creators: Guofan Zhang (Author) - BGI
Xiaodong Fang (Author) - BGI
Ximing Guo (Author) - Rutgers University, Marine and Coastal Sciences (SEBS)
Ruibang Luo (Author) - BGI
Li Li (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Fei Xu (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Pengcheng Yang (Author) - BGI
Linlin Zhang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Xiaotong Wang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Haigang Qi (Author) - Chinese Academy of Sciences
Zhiqiang Xiong (Author) - BGI
Huayong Que (Author) - Chinese Academy of Sciences
Yinlong Xie (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Peter W. H. Holland (Author) - University of Oxford
Jordi Paps (Author) - University of Oxford
Yabing Zhu (Author) - BGI
Fucun Wu (Author) - Chinese Academy of Sciences
Yuanxin Chen (Author) - BGI
Jiafeng Wang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Chunfang Peng (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Jie Meng (Author) - Chinese Academy of Sciences
Lan Yang (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Jun Liu (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Bo Wen (Author) - BGI
Na Zhang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Zhiyong Huang (Author) - BGI
Qihui Zhu (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Yue Feng (Author) - BGI
Andrew Mount (Author) - Clemson University
Dennis Hedgecock (Author) - Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA
Zhe Xu (Author) - Atlantic Cape Community Coll, Mays Landing, NJ 08330 USA
Yunjie Liu (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Tomislav Domazet-Lošo (Author) - Rudjer Boskovic Institute
Yishuai Du (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Xiaoqing Sun (Author) - BGI
Shoudu Zhang (Author) - Chinese Academy of Sciences
Binghang Liu (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Peizhou Cheng (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Xuanting Jiang (Author) - BGI
Dingding Fan (Author) - BGI
Juan Li (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Wei Wang (Author) - University of California, San Diego
Wenjing Fu (Author) - BGI
Tong Wang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Bo Wang (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Jibiao Zhang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Zhiyu Peng (Author) - BGI
Yingxiang Li (Author) - BGI
Na Li (Author) - Rutgers, The State University of New Jersey
Jinpeng Wang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Maoshan Chen (Author) - BGI
Yan He (Author) - Rutgers State Univ, Inst Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ 08349 USA
Fengji Tan (Author) - BGI
Xiaorui Song (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Qiumei Zheng (Author) - BGI
Ronglian Huang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Hailong Yang (Author) - BGI
Xuedi Du (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Li Chen (Author) - BGI Group
Mei Yang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Patrick M. Gaffney (Author) - Univ Delaware, Sch Marine Sci & Policy, Lewes, DE 19958 USA
Shan Wang (Author) - Rutgers, The State University of New Jersey
Longhai Luo (Author) - BGI
Zhicai She (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Yao Ming (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Wen Huang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Shu Zhang (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Baoyu Huang (Author) - Chinese Academy of Sciences
Yong Zhang (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Tao Qu (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Peixiang Ni (Author) - BGI
Guoying Miao (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Junyi Wang (Author) - BGI
Qiang Wang (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Christian E. W. Steinberg (Author) - Humboldt-Universität zu Berlin
Haiyan Wang (Author) - Chinese Academy of Sciences
Ning Li (Author) - BGI Shenzhen, Shenzhen 518083, Peoples R China
Lumin Qian (Author) - Rutgers, The State University of New Jersey
Guojie Zhang (Author) - BGI
Huanming Yang (Author) - BGI
Yingrui Li (Author) - BGI
Xiao Liu (Author) - Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Jian Wang (Author) - BGI
Ye Yin (Author) - BGI
Jun Wang (Author) - University of Copenhagen
Publication Details: Nature, Vol.490, pp.49-54
Date published: 09/19/2012
Publisher: Macmillan Publishers
Number of pages: 6
Academic Unit: Marine and Coastal Sciences (SEBS)
Language: English
Resource Type: Journal article
Identifiers: 991031747204504646