Abstract
On the basis of recent evidence that the carbohydrate structures L2/HNK-1 and L3 are shared by several neural cell adhesion molecules, we have suggested that other glycoproteins carrying these carbohydrate structures are adhesion molecules. We have isolated P
0, the major glycoprotein of peripheral myelin, from human sciatic nerve by immunoaffinity chromatography using a monoclonal L2 antibody column and tested it, along with bovine P
0, in Western blots for the presence of the two carbohydrate structures. Here we show that P
0 expresses the L2/HNK-1 and L3 carbohydrates.