Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

Mark S Silverberg; Jack Satsangi; Tariq Ahmad; Ian DR Arnott; Charles N Bernstein; Steven R Brant; Renzo Caprilli; Jean-Frédéric Colombel; Christoph Gasche; Karel Geboes; Derek P Jewell; Amir Karban; Edward V Loftus; A Salvador Peña; Robert H Riddell; David B Sachar; Stefan Schreiber; A Hillary Steinhart; Stephan R Targan; Severine Vermeire; Bryan F Warren

doi:10.1155/2005/269076

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Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

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Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

Mark S Silverberg, Jack Satsangi, Tariq Ahmad, Ian DR Arnott, Charles N Bernstein, Steven R Brant, Renzo Caprilli, Jean-Frédéric Colombel, Christoph Gasche, Karel Geboes, …

Canadian journal of gastroenterology, Vol.19(suppl a), pp.5-36A

2005

DOI: https://doi.org/10.1155/2005/269076

PMID: 16151544

Abstract

The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed current clinical classification systems in Crohn’s disease, ulcerative colitis and indeterminate colitis, and provided recommendations for clinical classification in practice. Progress with respect to integrating serological and genetic markers has been examined in detail, and the implications are discussed. While an integrated system is not proposed for clinical use at present, the introduction of a widely acceptable clinical subclassification is strongly advocated, which would allow detailed correlations among serotype, genotype and clinical phenotype to be examined and confirmed in independent cohorts of patients and, thereby, provide a vital foundation for future work.

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Title: Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
Creators: Mark S Silverberg - Department of Medicine, Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, Canada
Jack Satsangi - Department of Gastroenterology, Western General Hospital, University of Edinburgh, Edinburgh, UK
Tariq Ahmad - Gastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK
Ian DR Arnott - Department of Gastroenterology, Western General Hospital, University of Edinburgh, Edinburgh, UK
Charles N Bernstein - Department of Medicine, Section of Gastroenterology, University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, Canada
Steven R Brant - The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, John Hopkins University School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Renzo Caprilli - Department of Clinical Sciences, University of Rome “La Sapienza”, Rome, Italy
Jean-Frédéric Colombel - Department of Hepatogastroenterology and Registre EPIMAD, Hôpital HURIEZ, CH et U Lille, France
Christoph Gasche - Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria
Karel Geboes - Department of Pathology, University Hospital, Leuven, Belgium
Derek P Jewell - Department of Gastroenterology, University of Oxford, Oxford, UK
Amir Karban - Department of Gastroenterology, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
Edward V Loftus - Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
A Salvador Peña - Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
Robert H Riddell - Department of Pathology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
David B Sachar - Mount Sinai School of Medicine, New York, USA
Stefan Schreiber - Institute for Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
A Hillary Steinhart - Department of Medicine, Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, Canada
Stephan R Targan - Cedars-Sinai Division of Gastroenterology, Inflammatory Bowel Disease Center and Immunobiology Institute, UCLA School of Medicine, Los Angeles, California, USA
Severine Vermeire - Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Bryan F Warren - Department of Cellular Pathology, John Radcliffe Hospital, University of Oxford, Oxford, UK
Publication Details: Canadian journal of gastroenterology, Vol.19(suppl a), pp.5-36A
Date published: 2005
Academic Unit: Medicine - Gastroenterology and Hepatology (RWJMS)
Language: English
Resource Type: Journal article
Identifiers: 991031666208004646