rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

Linda E Kelemen; Madalene Earp; Brooke L Fridley; Georgia Chenevix-Trench; Peter A Fasching; Matthias W Beckmann; Arif B Ekici; Alexander Hein; Diether Lambrechts; Sandrina Lambrechts; Els Van Nieuwenhuysen; Ignace Vergote; Mary Anne Rossing; Jennifer A Doherty; Jenny Chang-Claude; Sabine Behrens; Kirsten B Moysich; Rikki Cannioto; Shashikant Lele; Kunle Odunsi; Marc T Goodman; Yurii B Shvetsov; Pamela J Thompson; Lynne R Wilkens; Thilo Dörk; Natalia Antonenkova; Natalia Bogdanova; Peter Hillemanns; Ingo B Runnebaum; Andreas du Bois; Philipp Harter; Florian Heitz; Ira Schwaab; Ralf Butzow; Liisa M Pelttari; Heli Nevanlinna; Francesmary Modugno; Robert P Edwards; Joseph L Kelley; Roberta B Ness; Beth Y Karlan; Jenny Lester; Sandra Orsulic; Christine Walsh; Susanne K Kjaer; Allan Jensen; Julie M Cunningham; Robert A Vierkant; Graham G Giles; Fiona Bruinsma; Melissa C Southey; Michelle A T Hildebrandt; Dong Liang; Karen Lu; Xifeng Wu; Thomas A Sellers; Douglas A Levine; Joellen M Schildkraut; Edwin S Iversen; Kathryn L Terry; Daniel W Cramer; Shelley S Tworoger; Elizabeth M Poole; Elisa V Bandera; Sara H Olson; Irene Orlow; Liv Cecilie Vestrheim Thomsen; Line Bjorge; Camilla Krakstad; Ingvild L Tangen; Lambertus A Kiemeney; Katja K H Aben; Leon F A G Massuger; Anne M van Altena; Tanja Pejovic; Yukie Bean; Melissa Kellar; Linda S Cook; Nhu D Le; Angela Brooks-Wilson; Jacek Gronwald; Cezary Cybulski; Anna Jakubowska; Jan Lubiński; Nicolas Wentzensen; Louise A Brinton; Jolanta Lissowska; Estrid Hogdall; Svend Aage Engelholm; Claus Hogdall; Lene Lundvall; Lotte Nedergaard; Paul D P Pharoah; Ed Dicks; Honglin Song; Jonathan P Tyrer; Iain McNeish; Nadeem Siddiqui; Karen Carty; Rosalind Glasspool; James Paul; Ian G Campbell; Diana Eccles; Alice S Whittemore; Valerie McGuire; Joseph H Rothstein; Weiva Sieh; Steven A Narod; Catherine M Phelan; John R McLaughlin; Harvey A Risch; Hoda Anton-Culver; Argyrios Ziogas; Usha Menon; Simon A Gayther; Aleksandra Gentry-Maharaj; Susan J Ramus; Anna H Wu; Celeste Leigh Pearce; Alice W Lee; Malcolm C Pike; Jolanta Kupryjanczyk; Agnieszka Podgorska; Joanna Plisiecka-Halasa; Wlodzimierz Sawicki; Ellen L Goode; Andrew Berchuck; Australian Ovarian Cancer Study Group

doi:10.3390/ijms19092473

Back

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

Journal article

Open access

Peer reviewed

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

Linda E Kelemen, Madalene Earp, Brooke L Fridley, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Diether Lambrechts, Sandrina Lambrechts, …

International journal of molecular sciences, Vol.19(9), p.2473

08/21/2018

DOI: https://doi.org/10.3390/ijms19092473

PMCID: PMC6163881

PMID: 30134598

Abstract

Adenocarcinoma, Mucinous - genetics

Adenocarcinoma, Mucinous - metabolism

Adenocarcinoma, Mucinous - pathology

Case-Control Studies

Female

Gene Expression Regulation, Neoplastic

Genetic Association Studies

Humans

Hydro-Lyases

Logistic Models

Middle Aged

Odds Ratio

Ovarian Neoplasms - genetics

Ovarian Neoplasms - metabolism

Ovarian Neoplasms - pathology

Polymorphism, Single Nucleotide

Proteins - genetics

Proteins - metabolism

Quantitative Trait Loci

Risk

RNA, Antisense - genetics

RNA, Antisense - metabolism

Thymidylate Synthase - genetics

Thymidylate Synthase - metabolism

Signal Transduction

Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the 3' gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97⁻1.22; = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03⁻1.24; = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed ( = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa ( = 0.51, = 1.7 × 10 ), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.

Files and links (1)

url

https://doi.org/10.3390/ijms19092473View

Version of Record (VoR) Open

Metrics

15 Record Views

3 Times Cited - Web of Science

See more details

Details

Title: rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology
Creators: Linda E Kelemen - Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. Kelemen@musc.edu
Madalene Earp - Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA. madalene.earp@ucalgary.ca
Brooke L Fridley - Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 USA. brooke.fridley@moffitt.org
Georgia Chenevix-Trench - Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia. georgia.trench@qimr.edu.au
Peter A Fasching - Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. peter.fasching@uk-erlangen.de
Matthias W Beckmann - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, 91054 Erlangen, Germany. fk-direktion@uk-erlangen.de
Arif B Ekici - Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen 91054, Germany. arif.ekici@uk-erlangen.de
Alexander Hein - Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, 91054 Erlangen, Germany. alexander.hein@uk-erlangen.de
Diether Lambrechts - Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven 3000, Belgium. diether.lambrechts@vib-kuleuven.be
Sandrina Lambrechts - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium. sandrina.lambrechts@mumc.nl
Els Van Nieuwenhuysen - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium. els.vannieuwenhuysen@uzleuven.be
Ignace Vergote - Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium. ignace.vergote@uzleuven.be
Mary Anne Rossing - Department of Epidemiology, University of Washington, Seattle, WA 98402, USA. mrossing@fhcrc.org
Jennifer A Doherty - Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA. jennifer.doherty@hci.utah.edu
Jenny Chang-Claude - University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. j.chang-claude@dkfz-heidelberg.de
Sabine Behrens - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. s.behrens@dkfz.de
Kirsten B Moysich - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. moysich@roswellpark.org
Rikki Cannioto - Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. rikki.cannioto@roswellpark.org
Shashikant Lele - Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. shashi.lele@roswellpark.org
Kunle Odunsi - Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. kunle.odunsi@roswellpark.org
Marc T Goodman - Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. marc.goodman@cshs.org
Yurii B Shvetsov - Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. yshvetso@cc.hawaii.edu
Pamela J Thompson - Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. pamela.thompson@cshs.org
Lynne R Wilkens - Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. lynne@cc.hawaii.edu
Thilo Dörk - Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany. doerk.thilo@mh-hannover.de
Natalia Antonenkova - Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk 223040, Belarus. antonenkova.natalia.omd@tut.by
Natalia Bogdanova - Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany. bogdanova.natalia@mh-hannover.de
Peter Hillemanns - Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover 30625, Germany. hillemanns.peter@mh-hannover.de
Ingo B Runnebaum - Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena 07743, Germany. ingo.runnebaum@med.uni-jena.de
Andreas du Bois - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany. prof.dubois@googlemail.com
Philipp Harter - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany. p.harter@gmx.de
Florian Heitz - Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden 65199, Germany. florian.heitz@gmx.net
Ira Schwaab - Praxis für Humangenetik, Wiesbaden 65187, Germany. iraschwaab@gmx.de
Ralf Butzow - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland. ralf.butzow@hus.fi
Liisa M Pelttari - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland. liisa.pelttari@helsinki.fi
Heli Nevanlinna - Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland. heli.nevanlinna@hus.fi
Francesmary Modugno - Women's Cancer Research Program, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, PA 15213, USA. fm@cs.cmu.edu
Robert P Edwards - Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. redwards@mail.magee.edu
Joseph L Kelley - Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. jkelley@mail.magee.edu
Roberta B Ness - School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA. roberta.b.ness@uth.tmc.edu
Beth Y Karlan - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. beth.karlan@cshs.org
Jenny Lester - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. jenny.lester@cshs.org
Sandra Orsulic - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. sandra.orsulic@cshs.org
Christine Walsh - Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. christine.walsh@cshs.org
Susanne K Kjaer - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Centre, DK-2100 Copenhagen, Denmark. susanne@cancer.dk
Allan Jensen - Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Centre, DK-2100 Copenhagen, Denmark. allan@cancer.dk
Julie M Cunningham - Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA. cunningham.julie@mayo.edu
Robert A Vierkant - Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA. vierkant.robert@mayo.edu
Graham G Giles - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC 3800, Australia. graham.giles@cancervic.org.au
Fiona Bruinsma - Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC 3004, Australia. fiona.bruinsma@cancervic.org.au
Melissa C Southey - Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia. msouthey@unimelb.edu.au
Michelle A T Hildebrandt - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. mhildebr@mdanderson.org
Dong Liang - College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA. liang_dx@tsu.edu
Karen Lu - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. khlu@mdanderson.org
Xifeng Wu - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. xwu@mdanderson.org
Thomas A Sellers - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. thomas.sellers@moffitt.org
Douglas A Levine - Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA. Douglas.Levine@nyumc.org
Joellen M Schildkraut - Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA. jms2yf@virginia.edu
Edwin S Iversen - Department of Statistical Science, Duke University, Durham, NC 27708, USA. iversen@stat.duke.edu
Kathryn L Terry - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. kterry@partners.org
Daniel W Cramer - Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. dcramer@partners.org
Shelley S Tworoger - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. shelley.tworoger@moffitt.org
Elizabeth M Poole - Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. nhlip@channing.harvard.edu
Elisa V Bandera - Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA. banderel@cinj.rutgers.edu
Sara H Olson - Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY 10065, USA. olsons@mskcc.org
Irene Orlow - Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY 10065, USA. orlowi@mskcc.org
Liv Cecilie Vestrheim Thomsen - Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen 5020, Norway. Liv.Vestrheim@uib.no
Line Bjorge - Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen 5020, Norway. line.bjorge@uib.no
Camilla Krakstad - Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen 5020, Norway. camilla.krakstad@k2.uib.no
Ingvild L Tangen - Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen 5020, Norway. ingvild.tangen@k2.uib.no
Lambertus A Kiemeney - Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen 6525 EZ, The Netherlands. bart.kiemeney@radboudumc.nl
Katja K H Aben - Netherlands Comprehensive Cancer Organisation, Utrecht 3511 DT, The Netherlands. k.aben@iknl.nl
Leon F A G Massuger - Radboud University Medical Centre, Department of Obstetrics and Gynecology, Nijmegen 6525 GA, The Netherlands. leon.massuger@radboudumc.nl
Anne M van Altena - Radboud University Medical Centre, Department of Obstetrics and Gynecology, Nijmegen 6525 GA, The Netherlands. anne.vanaltena@radboudumc.nl
Tanja Pejovic - Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA. pejovict@ohsu.edu
Yukie Bean - Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA. beany@ohsu.edu
Melissa Kellar - Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA. kellar@ohsu.edu
Linda S Cook - Division of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA. lcook@salud.unm.edu
Nhu D Le - Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada. nle@bccrc.ca
Angela Brooks-Wilson - Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. abrooks-wilson@bcgsc.ca
Jacek Gronwald - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland. jgron@sci.pam.szczecin.pl
Cezary Cybulski - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland. cezarycy@sci.pam.szczecin.pl
Anna Jakubowska - Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin 70-111, Poland. aniaj@sci.pam.szczecin.pl
Jan Lubiński - International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland. lubinski@pum.edu.pl
Nicolas Wentzensen - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. wentzenn@mail.nih.gov
Louise A Brinton - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. brintonl@mail.nih.gov
Jolanta Lissowska - Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland. lissowsj@coi.waw.pl
Estrid Hogdall - Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen DK-2100, Denmark. hogdall@dadlnet.dk
Svend Aage Engelholm - Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark. svend.aage.engelholm@rh.regionh.dk
Claus Hogdall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark. claus.hogdall@regionh.dk
Lene Lundvall - Department of Gynaecology, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark. lene.lundvall@regionh.dk
Lotte Nedergaard - Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark. lotte.thomsen.01@regionh.dk
Paul D P Pharoah - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. pp10001@medschl.cam.ac.uk
Ed Dicks - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. emd43@medschl.cam.ac.uk
Honglin Song - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. hs310@medschl.cam.ac.uk
Jonathan P Tyrer - The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. jpt34@medschl.cam.ac.uk
Iain McNeish - Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK. i.mcneish@imperial.ac.uk
Nadeem Siddiqui - Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK. nadeem.siddiqui@ggc.scot.nhs.uk
Karen Carty - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK. karen.carty@glasgow.ac.uk
Rosalind Glasspool - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK. ros.glasspool@ggc.scot.nhs.uk
James Paul - Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK. james.paul@glasgow.ac.uk
Ian G Campbell - Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3000, Australia. ian.campbell@petermac.org
Diana Eccles - Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. d.m.eccles@soton.ac.uk
Alice S Whittemore - Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA. alicesw@stanford.edu
Valerie McGuire - Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA. vmcguire@stanford.edu
Joseph H Rothstein - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. joseph.rothstein@mssm.edu
Weiva Sieh - Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. weiva.sieh@mssm.edu
Steven A Narod - Women's College Research Institute, University of Toronto, Toronto, ON M5S 1A8, Canada. steven.narod@wchospital.ca
Catherine M Phelan - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. ocacdata@duke.edu
John R McLaughlin - Public Health Ontario, Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada. jmclaugh@lunenfeld.ca
Harvey A Risch - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA. harvey.risch@yale.edu
Hoda Anton-Culver - Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, CA 92617, USA. hantoncu@uci.edu
Argyrios Ziogas - Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, CA 92617, USA. aziogas@uci.edu
Usha Menon - MRC Clinical Trials at UCL, Institute of Clinical Trials & Methodology, Population Health Sciences, University College London, London, WC1V 6LJ, UK. u.menon@ucl.ac.uk
Simon A Gayther - Department of Biomedical Sciences and Center for Cancer Prevention and Translational Genomics, Samuel Oschin Comprensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. simon.gayther@cshs.org
Aleksandra Gentry-Maharaj - MRC Clinical Trials at UCL, Institute of Clinical Trials & Methodology, Population Health Sciences, University College London, London, WC1V 6LJ, UK. a.gentry-maharaj@ucl.ac.uk
Susan J Ramus - The Kinghorn Cancer Centre, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia. s.ramus@unsw.edu.au
Anna H Wu - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA. anna.wu@med.usc.edu
Celeste Leigh Pearce - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA. lpearce@umich.edu
Alice W Lee - Department of Public Health, California State University, Fullerton, CA 92831, USA. alicelee@fullerton.edu
Malcolm C Pike - Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA. pikem@mskcc.org
Jolanta Kupryjanczyk - Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland. jkupry@coi.waw.pl
Agnieszka Podgorska - Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland. ag.podgorski@yahoo.de
Joanna Plisiecka-Halasa - Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland. jopliha@coi.waw.pl
Wlodzimierz Sawicki - Department of Obstetrics, Gynecology and Oncology, Second Faculty of Medicine, Medical University of Warsaw, Mazovian Bródno Hospital, Warsaw 03-242, Poland. saw55@wp.pl
Ellen L Goode - Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA. egoode@mayo.edu
Andrew Berchuck - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA. andrew.berchuck@duke.edu
Australian Ovarian Cancer Study Group
Publication Details: International journal of molecular sciences, Vol.19(9), p.2473
Date published: 08/21/2018
Grant note: G0601891 / Medical Research Council P50 CA136393 / NCI NIH HHS G0501974 / Medical Research Council P30 CA008748 / NCI NIH HHS P30 CA071789 / NCI NIH HHS
Academic Unit: Cancer Epidemiology and Health Outcomes
Language: English
Resource Type: Journal article
Identifiers: 991031665880004646